9 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGGOP00000046758	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	GBP5	Guanylate binding protein 5. (586 aa)
	IRGM	Immunity related GTPase M. (181 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	GBP6	Guanylate binding protein family member 6. (633 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
	GBP2	Guanylate binding protein 2. (591 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	ENSGGOP00000046758	ENSGGOP00000006002	ENSGGOP00000046758	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.991
AIM2	GBP2	ENSGGOP00000006002	ENSGGOP00000001692	Absent in melanoma 2.	Guanylate binding protein 2.	0.466
AIM2	GBP5	ENSGGOP00000006002	ENSGGOP00000001639	Absent in melanoma 2.	Guanylate binding protein 5.	0.424
AIM2	IFNG	ENSGGOP00000006002	ENSGGOP00000005908	Absent in melanoma 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.450
AIM2	NOD2	ENSGGOP00000006002	ENSGGOP00000010525	Absent in melanoma 2.	Nucleotide binding oligomerization domain containing 2.	0.489
ENSGGOP00000046758	AIM2	ENSGGOP00000046758	ENSGGOP00000006002	Caspase 1; Belongs to the peptidase C14A family.	Absent in melanoma 2.	0.991
ENSGGOP00000046758	IFNG	ENSGGOP00000046758	ENSGGOP00000005908	Caspase 1; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.744
ENSGGOP00000046758	NOD2	ENSGGOP00000046758	ENSGGOP00000010525	Caspase 1; Belongs to the peptidase C14A family.	Nucleotide binding oligomerization domain containing 2.	0.789
GBP2	AIM2	ENSGGOP00000001692	ENSGGOP00000006002	Guanylate binding protein 2.	Absent in melanoma 2.	0.466
GBP2	GBP5	ENSGGOP00000001692	ENSGGOP00000001639	Guanylate binding protein 2.	Guanylate binding protein 5.	0.940
GBP2	IFNG	ENSGGOP00000001692	ENSGGOP00000005908	Guanylate binding protein 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.588
GBP2	IRGM	ENSGGOP00000001692	ENSGGOP00000018654	Guanylate binding protein 2.	Immunity related GTPase M.	0.442
GBP2	SNAPIN	ENSGGOP00000001692	ENSGGOP00000001786	Guanylate binding protein 2.	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...]	0.430
GBP5	AIM2	ENSGGOP00000001639	ENSGGOP00000006002	Guanylate binding protein 5.	Absent in melanoma 2.	0.424
GBP5	GBP2	ENSGGOP00000001639	ENSGGOP00000001692	Guanylate binding protein 5.	Guanylate binding protein 2.	0.940
GBP5	IFNG	ENSGGOP00000001639	ENSGGOP00000005908	Guanylate binding protein 5.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.572
GBP5	SNAPIN	ENSGGOP00000001639	ENSGGOP00000001786	Guanylate binding protein 5.	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...]	0.404
GBP6	IFNG	ENSGGOP00000010513	ENSGGOP00000005908	Guanylate binding protein family member 6.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.431
GBP6	SNAPIN	ENSGGOP00000010513	ENSGGOP00000001786	Guanylate binding protein family member 6.	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...]	0.502
IFNG	AIM2	ENSGGOP00000005908	ENSGGOP00000006002	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Absent in melanoma 2.	0.450