STRINGSTRING
G3R4K9_GORGO G3R4K9_GORGO ENSGGOP00000046758 ENSGGOP00000046758 ENSGGOP00000043564 ENSGGOP00000043564 ENSGGOP00000038498 ENSGGOP00000038498 PIK3C3 PIK3C3 ENSGGOP00000030478 ENSGGOP00000030478 STAT1 STAT1 TBK1 TBK1 TRIM23 TRIM23 TRIM5 TRIM5 IL2 IL2 TLR4 TLR4 TAB3 TAB3 TRIM32 TRIM32 JAK1 JAK1 TRIM15 TRIM15 IRF9 IRF9 TRIM27 TRIM27 G3RG63_GORGO G3RG63_GORGO DDX41 DDX41 IL10 IL10 TRIM28 TRIM28 NLRP1 NLRP1 NOD2 NOD2 TRIM44 TRIM44 TRAF6 TRAF6 TYK2 TYK2 AIM2 AIM2 G3QTI0_GORGO G3QTI0_GORGO TRIM21 TRIM21 TRIM38 TRIM38 TRIM14 TRIM14 BBOX1 BBOX1 G3R3U7_GORGO G3R3U7_GORGO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3R4K9_GORGOTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (907 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
ENSGGOP00000043564Interferon regulatory factor 3. (452 aa)
ENSGGOP00000038498Tripartite motif containing 4. (500 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TBK1TANK binding kinase 1. (729 aa)
TRIM23Tripartite motif containing 23. (574 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
TRIM32Tripartite motif containing 32. (653 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TRIM15Tripartite motif containing 15. (465 aa)
IRF9Interferon regulatory factor 9. (392 aa)
TRIM27Tripartite motif containing 27. (513 aa)
G3RG63_GORGOISG15 ubiquitin like modifier. (165 aa)
DDX41DEAD-box helicase 41. (622 aa)
IL10Interleukin 10. (178 aa)
TRIM28Tripartite motif containing 28. (701 aa)
NLRP1NLR family pyrin domain containing 1. (1471 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
TRIM44Tripartite motif containing 44. (344 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
AIM2Absent in melanoma 2. (343 aa)
G3QTI0_GORGOSignal transducer and activator of transcription. (853 aa)
TRIM21Tripartite motif containing 21. (475 aa)
TRIM38Tripartite motif containing 38. (465 aa)
TRIM14B box-type domain-containing protein. (110 aa)
BBOX1Gamma-butyrobetaine hydroxylase 1. (387 aa)
G3R3U7_GORGOMitochondrial antiviral signaling protein. (481 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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