(26 nodes) (2018) Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex. network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOPX	HOP homeobox. (112 aa)
	G3QZ51_GORGO	Fibroblast growth factor receptor. (822 aa)
	ADAM30	ADAM metallopeptidase domain 30. (791 aa)
	NOTCH3	Notch receptor 3. (2317 aa)
	PDGFD	Platelet derived growth factor D. (370 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	EOMES	Eomesodermin. (705 aa)
	ADGRG1	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	TBC1D1	Uncharacterized protein. (1168 aa)
	FOXP2	Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (666 aa)
	STX12	Syntaxin 12; Belongs to the syntaxin family. (276 aa)
	CBWD1	Uncharacterized protein. (58 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1002 aa)
	ENSGGOP00000041668	Fibroblast growth factor receptor. (808 aa)
	ENSGGOP00000041455	Uncharacterized protein. (226 aa)
	FAM72A	Uncharacterized protein. (77 aa)
	PTTG2	Pituitary tumor-transforming 2. (196 aa)
	FABP7	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
	NEUROG1	Neurogenin 1. (237 aa)
	PAX6	Uncharacterized protein. (475 aa)
	NOTCH1	Uncharacterized protein. (1606 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1183 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM30	ENSGGOP00000041455	ENSGGOP00000003931	ENSGGOP00000041455	ADAM metallopeptidase domain 30.	Uncharacterized protein.	0.400
ADAM30	FABP7	ENSGGOP00000003931	ENSGGOP00000036299	ADAM metallopeptidase domain 30.	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.412
ADAM30	FAM72A	ENSGGOP00000003931	ENSGGOP00000040015	ADAM metallopeptidase domain 30.	Uncharacterized protein.	0.498
ADAM30	NEUROG1	ENSGGOP00000003931	ENSGGOP00000017462	ADAM metallopeptidase domain 30.	Neurogenin 1.	0.410
ADAM30	PTTG2	ENSGGOP00000003931	ENSGGOP00000038333	ADAM metallopeptidase domain 30.	Pituitary tumor-transforming 2.	0.450
ADAM30	STX12	ENSGGOP00000003931	ENSGGOP00000047067	ADAM metallopeptidase domain 30.	Syntaxin 12; Belongs to the syntaxin family.	0.602
ADAM30	TBC1D1	ENSGGOP00000003931	ENSGGOP00000007038	ADAM metallopeptidase domain 30.	Uncharacterized protein.	0.503
ADGRG1	DLL1	ENSGGOP00000008255	ENSGGOP00000005392	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.584
ADGRG1	FABP7	ENSGGOP00000008255	ENSGGOP00000036299	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.609
ADGRG1	HOPX	ENSGGOP00000008255	ENSGGOP00000004535	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	HOP homeobox.	0.494
ADGRG1	ITGAV	ENSGGOP00000008255	ENSGGOP00000043070	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.582
ADGRG1	NEUROG1	ENSGGOP00000008255	ENSGGOP00000017462	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	Neurogenin 1.	0.622
ADGRG1	NOTCH3	ENSGGOP00000008255	ENSGGOP00000002228	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	Notch receptor 3.	0.447
ADGRG1	PDGFD	ENSGGOP00000008255	ENSGGOP00000002070	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	Platelet derived growth factor D.	0.704
ADGRG1	STX12	ENSGGOP00000008255	ENSGGOP00000047067	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	Syntaxin 12; Belongs to the syntaxin family.	0.445
CBWD1	ENSGGOP00000041455	ENSGGOP00000043809	ENSGGOP00000041455	Uncharacterized protein.	Uncharacterized protein.	0.473
CBWD1	FAM72A	ENSGGOP00000043809	ENSGGOP00000040015	Uncharacterized protein.	Uncharacterized protein.	0.703
DLL1	ADGRG1	ENSGGOP00000005392	ENSGGOP00000008255	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]	0.584
DLL1	FABP7	ENSGGOP00000005392	ENSGGOP00000036299	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.441
DLL1	FAM72A	ENSGGOP00000005392	ENSGGOP00000040015	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.432