35 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3QTI0_GORGO	Signal transducer and activator of transcription. (853 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (662 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (271 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	IL22RA1	Interleukin 22 receptor subunit alpha 1. (574 aa)
	CXCL16	C-X-C motif chemokine ligand 16. (273 aa)
	G3QT76_GORGO	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	G3R5S5_GORGO	Major histocompatibility complex, class II, DO beta. (273 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	SOCS1	Suppressor of cytokine signaling 1. (211 aa)
	G3RG63_GORGO	ISG15 ubiquitin like modifier. (165 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1025 aa)
	STING1	Transmembrane protein 173. (379 aa)
	CCL2	C-C motif chemokine. (99 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
	IFNB1	Interferon beta 1. (187 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	G3RRQ8_GORGO	AXL receptor tyrosine kinase. (843 aa)
	IL6	Interleukin 6. (234 aa)
	ALB	Albumin. (609 aa)
	CD40	CD40 molecule. (277 aa)
	GNB4	G protein subunit beta 4. (340 aa)
	CXCL5	C-X-C motif chemokine. (114 aa)
	ENSGGOP00000030478	Tyrosine-protein kinase. (1151 aa)
	IL15RA	Sushi domain-containing protein. (323 aa)
	CCND1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	ENSGGOP00000043564	Interferon regulatory factor 3. (452 aa)
	CADM1	Cell adhesion molecule 1. (450 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	VEGFC	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (230 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CCL2	ENSGGOP00000023949	ENSGGOP00000015811	Albumin.	C-C motif chemokine.	0.531
ALB	CXCL10	ENSGGOP00000023949	ENSGGOP00000010309	Albumin.	C-X-C motif chemokine.	0.441
ALB	G3QT76_GORGO	ENSGGOP00000023949	ENSGGOP00000005887	Albumin.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.672
ALB	IFNB1	ENSGGOP00000023949	ENSGGOP00000016838	Albumin.	Interferon beta 1.	0.432
ALB	IL1A	ENSGGOP00000023949	ENSGGOP00000003468	Albumin.	Interleukin-1; Belongs to the IL-1 family.	0.520
ALB	IL6	ENSGGOP00000023949	ENSGGOP00000018546	Albumin.	Interleukin 6.	0.758
ALB	SRC	ENSGGOP00000023949	ENSGGOP00000018321	Albumin.	Tyrosine-protein kinase.	0.484
ALB	TLR2	ENSGGOP00000023949	ENSGGOP00000003012	Albumin.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.544
CADM1	CCL2	ENSGGOP00000046319	ENSGGOP00000015811	Cell adhesion molecule 1.	C-C motif chemokine.	0.411
CADM1	IL6	ENSGGOP00000046319	ENSGGOP00000018546	Cell adhesion molecule 1.	Interleukin 6.	0.613
CARD11	G3QT76_GORGO	ENSGGOP00000046946	ENSGGOP00000005887	Caspase recruitment domain family member 11.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.436
CARD11	MYD88	ENSGGOP00000046946	ENSGGOP00000003761	Caspase recruitment domain family member 11.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.477
CCL2	ALB	ENSGGOP00000015811	ENSGGOP00000023949	C-C motif chemokine.	Albumin.	0.531
CCL2	CADM1	ENSGGOP00000015811	ENSGGOP00000046319	C-C motif chemokine.	Cell adhesion molecule 1.	0.411
CCL2	CCND1	ENSGGOP00000015811	ENSGGOP00000032889	C-C motif chemokine.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.412
CCL2	CD40	ENSGGOP00000015811	ENSGGOP00000024263	C-C motif chemokine.	CD40 molecule.	0.450
CCL2	CXCL10	ENSGGOP00000015811	ENSGGOP00000010309	C-C motif chemokine.	C-X-C motif chemokine.	0.873
CCL2	CXCL16	ENSGGOP00000015811	ENSGGOP00000005361	C-C motif chemokine.	C-X-C motif chemokine ligand 16.	0.614
CCL2	CXCL5	ENSGGOP00000015811	ENSGGOP00000028082	C-C motif chemokine.	C-X-C motif chemokine.	0.868
CCL2	ENSGGOP00000030478	ENSGGOP00000015811	ENSGGOP00000030478	C-C motif chemokine.	Tyrosine-protein kinase.	0.468