32 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL2	BCL2 apoptosis regulator. (239 aa)
	G3QES1_GORGO	DGCR8 microprocessor complex subunit. (773 aa)
	NCAPH	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (745 aa)
	SIL1	SIL1 nucleotide exchange factor. (468 aa)
	NCAPD2	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1401 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (868 aa)
	G3R860_GORGO	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1022 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	SPAG5	Sperm associated antigen 5. (1198 aa)
	PLK4	Polo like kinase 4. (880 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
	KNTC1	Kinetochore associated 1. (2209 aa)
	G3SDT0_GORGO	Histone H2B; Belongs to the histone H2B family. (126 aa)
	CENPA	Centromere protein A. (140 aa)
	ENSGGOP00000041365	Drosha ribonuclease III. (1380 aa)
	INCENP	Inner centromere protein. (903 aa)
	SPC24	Uncharacterized protein. (209 aa)
	NUF2	NUF2 component of NDC80 kinetochore complex. (464 aa)
	XPO5	Exportin 5. (1195 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
	KIF20A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (890 aa)
	KIF23	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (960 aa)
	CEP55	Centrosomal protein 55. (469 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
	HJURP	Holliday junction recognition protein. (743 aa)
	G3QJF5_GORGO	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1339 aa)
	RACGAP1	Rac GTPase activating protein 1. (632 aa)
	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B. (1068 aa)
	C5	Complement C5. (1646 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	ENSGGOP00000041365	ENSGGOP00000011130	ENSGGOP00000041365	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.946
AGO2	G3QES1_GORGO	ENSGGOP00000011130	ENSGGOP00000000770	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DGCR8 microprocessor complex subunit.	0.853
AGO2	GAPDH	ENSGGOP00000011130	ENSGGOP00000009331	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.581
AGO2	XPO5	ENSGGOP00000011130	ENSGGOP00000007781	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exportin 5.	0.870
AURKA	AURKB	ENSGGOP00000007041	ENSGGOP00000002820	Aurora kinase A; Belongs to the protein kinase superfamily.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.874
AURKA	BCL2	ENSGGOP00000007041	ENSGGOP00000000778	Aurora kinase A; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.465
AURKA	BUB1B	ENSGGOP00000007041	ENSGGOP00000002254	Aurora kinase A; Belongs to the protein kinase superfamily.	BUB1 mitotic checkpoint serine/threonine kinase B.	0.870
AURKA	CCNA2	ENSGGOP00000007041	ENSGGOP00000002134	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin A2; Belongs to the cyclin family.	0.911
AURKA	CDK1	ENSGGOP00000007041	ENSGGOP00000012982	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.937
AURKA	CENPA	ENSGGOP00000007041	ENSGGOP00000026777	Aurora kinase A; Belongs to the protein kinase superfamily.	Centromere protein A.	0.935
AURKA	CEP55	ENSGGOP00000007041	ENSGGOP00000003880	Aurora kinase A; Belongs to the protein kinase superfamily.	Centrosomal protein 55.	0.895
AURKA	G3QJF5_GORGO	ENSGGOP00000007041	ENSGGOP00000002549	Aurora kinase A; Belongs to the protein kinase superfamily.	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.577
AURKA	G3R860_GORGO	ENSGGOP00000007041	ENSGGOP00000011560	Aurora kinase A; Belongs to the protein kinase superfamily.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.894
AURKA	HJURP	ENSGGOP00000007041	ENSGGOP00000002582	Aurora kinase A; Belongs to the protein kinase superfamily.	Holliday junction recognition protein.	0.832
AURKA	INCENP	ENSGGOP00000007041	ENSGGOP00000042461	Aurora kinase A; Belongs to the protein kinase superfamily.	Inner centromere protein.	0.983
AURKA	KIF20A	ENSGGOP00000007041	ENSGGOP00000006958	Aurora kinase A; Belongs to the protein kinase superfamily.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.885
AURKA	KIF23	ENSGGOP00000007041	ENSGGOP00000003903	Aurora kinase A; Belongs to the protein kinase superfamily.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.820
AURKA	KNTC1	ENSGGOP00000007041	ENSGGOP00000025682	Aurora kinase A; Belongs to the protein kinase superfamily.	Kinetochore associated 1.	0.523
AURKA	NCAPD2	ENSGGOP00000007041	ENSGGOP00000009325	Aurora kinase A; Belongs to the protein kinase superfamily.	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	0.615
AURKA	NCAPH	ENSGGOP00000007041	ENSGGOP00000046226	Aurora kinase A; Belongs to the protein kinase superfamily.	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.	0.787