STRINGSTRING
SRP9 SRP9 SECISBP2 SECISBP2 SELENOK SELENOK PRMT7 PRMT7 PCNA PCNA G3QHL3_GORGO G3QHL3_GORGO LRP6 LRP6 SMPD1 SMPD1 ERCC8 ERCC8 WDR5 WDR5 GADD45G GADD45G TXN TXN KDM5C KDM5C CERS5 CERS5 HAT1 HAT1 SRP14 SRP14 PDGFRA PDGFRA GADD45A GADD45A SPHKAP SPHKAP HDAC1 HDAC1 SPTLC2 SPTLC2 VEGFB VEGFB SPTLC3 SPTLC3 IGF1R IGF1R STT3B STT3B KDSR KDSR CDK7 CDK7 CTH CTH DNMT1 DNMT1 LRP2 LRP2 TNFRSF9 TNFRSF9 SPHK1 SPHK1 G3RNX2_GORGO G3RNX2_GORGO G3RQE7_GORGO G3RQE7_GORGO TNFSF4 TNFSF4 GADD45GIP1 GADD45GIP1 SRP68 SRP68 TNFAIP8L3 TNFAIP8L3 SPCS1 SPCS1 SPCS3 SPCS3 SMPDL3A SMPDL3A CASP3 CASP3 DCAF7 DCAF7 HDAC9 HDAC9 CYCS CYCS SRP72 SRP72 ENSGGOP00000029430 ENSGGOP00000029430 ENSGGOP00000029715 ENSGGOP00000029715 SPCS2 SPCS2 PDGFA PDGFA CUL2 CUL2 EIF5 EIF5 TNFRSF21 TNFRSF21 CUL1 CUL1 ENSGGOP00000045734 ENSGGOP00000045734 SRP54 SRP54 EIF4A3 EIF4A3 ENSGGOP00000049412 ENSGGOP00000049412 EIF6 EIF6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRP9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (86 aa)
SECISBP2SECIS binding protein 2. (855 aa)
SELENOKSelenoprotein K. (93 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (692 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
G3QHL3_GORGOPhospholipid phosphatase 1. (285 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
WDR5WD repeat domain 5. (334 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
KDM5CLysine demethylase 5C. (1560 aa)
CERS5Ceramide synthase 5. (392 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (447 aa)
SRP14Uncharacterized protein. (134 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SPHKAPSPHK1 interactor, AKAP domain containing. (1700 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (566 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
STT3BSTT3 oligosaccharyltransferase complex catalytic subunit B. (721 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
CTHCystathionine gamma-lyase. (405 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1658 aa)
LRP2LDL receptor related protein 2. (4653 aa)
TNFRSF9TNF receptor superfamily member 9. (255 aa)
SPHK1Sphingosine kinase 1. (472 aa)
G3RNX2_GORGOProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
GADD45GIP1GADD45G interacting protein 1. (222 aa)
SRP68Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (618 aa)
TNFAIP8L3TNF alpha induced protein 8 like 3. (292 aa)
SPCS1Signal peptidase complex subunit 1. (169 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
SMPDL3AAcid sphingomyelinase-like phosphodiesterase. (453 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
DCAF7DDB1 and CUL4 associated factor 7. (342 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
SRP72Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. (672 aa)
ENSGGOP00000029430Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (255 aa)
ENSGGOP00000029715Signal peptidase complex subunit 2. (257 aa)
SPCS2Uncharacterized protein. (192 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (234 aa)
CUL2Cullin 2; Belongs to the cullin family. (764 aa)
EIF5Eukaryotic translation initiation factor 5. (427 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
CUL1Cullin domain-containing protein; Belongs to the cullin family. (323 aa)
ENSGGOP00000045734Uncharacterized protein. (127 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (420 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (257 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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