(12 nodes) (2019) Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice. network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	COL3A1	Collagen type III alpha 1 chain. (1466 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	GCG	Glucagon. (180 aa)
	DPP4	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
	ACE	Angiotensin-converting enzyme. (1306 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (486 aa)
	PYY	Peptide YY. (97 aa)
	COL1A1	Collagen type I alpha 1 chain. (1464 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	DPP4	ENSGGOP00000000633	ENSGGOP00000027808	Angiotensin-converting enzyme.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.672
ACE	GCG	ENSGGOP00000000633	ENSGGOP00000026426	Angiotensin-converting enzyme.	Glucagon.	0.480
ACE	GOT1	ENSGGOP00000000633	ENSGGOP00000002510	Angiotensin-converting enzyme.	Aspartate aminotransferase.	0.425
ACE	INS	ENSGGOP00000000633	ENSGGOP00000034798	Angiotensin-converting enzyme.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.625
ACE	TGFB1	ENSGGOP00000000633	ENSGGOP00000026415	Angiotensin-converting enzyme.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.483
COL1A1	COL3A1	ENSGGOP00000012899	ENSGGOP00000016147	Collagen type I alpha 1 chain.	Collagen type III alpha 1 chain.	0.997
COL1A1	PDGFB	ENSGGOP00000012899	ENSGGOP00000015152	Collagen type I alpha 1 chain.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.707
COL1A1	TGFB1	ENSGGOP00000012899	ENSGGOP00000026415	Collagen type I alpha 1 chain.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.608
COL3A1	COL1A1	ENSGGOP00000016147	ENSGGOP00000012899	Collagen type III alpha 1 chain.	Collagen type I alpha 1 chain.	0.997
COL3A1	TGFB1	ENSGGOP00000016147	ENSGGOP00000026415	Collagen type III alpha 1 chain.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.575
DPP4	ACE	ENSGGOP00000027808	ENSGGOP00000000633	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Angiotensin-converting enzyme.	0.672
DPP4	GCG	ENSGGOP00000027808	ENSGGOP00000026426	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Glucagon.	0.916
DPP4	INS	ENSGGOP00000027808	ENSGGOP00000034798	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.615
DPP4	PYY	ENSGGOP00000027808	ENSGGOP00000008677	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Peptide YY.	0.676
GCG	ACE	ENSGGOP00000026426	ENSGGOP00000000633	Glucagon.	Angiotensin-converting enzyme.	0.480
GCG	DPP4	ENSGGOP00000026426	ENSGGOP00000027808	Glucagon.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.916
GCG	INS	ENSGGOP00000026426	ENSGGOP00000034798	Glucagon.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.777
GCG	NR1H4	ENSGGOP00000026426	ENSGGOP00000007955	Glucagon.	Nuclear receptor subfamily 1 group H member 4.	0.534
GCG	PYY	ENSGGOP00000026426	ENSGGOP00000008677	Glucagon.	Peptide YY.	0.835
GOT1	ACE	ENSGGOP00000002510	ENSGGOP00000000633	Aspartate aminotransferase.	Angiotensin-converting enzyme.	0.425