(25 nodes) (2018) IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral Infections. network (Gorilla gorilla)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1319 aa)
	SIN3A	Uncharacterized protein. (154 aa)
	ENSGGOP00000043564	Interferon regulatory factor 3. (452 aa)
	EIF4B	Eukaryotic translation initiation factor 4B. (611 aa)
	CD63	Tetraspanin. (238 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	POLR2A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1960 aa)
	PHF8	PHD finger protein 8. (1060 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	TBP	TATA-box binding protein. (332 aa)
	G3R765_GORGO	Chromodomain helicase DNA binding protein 1. (1679 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	G3QTI0_GORGO	Signal transducer and activator of transcription. (853 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	IFITM1	Interferon induced transmembrane protein 1. (125 aa)
	CD4	CD4 molecule. (458 aa)
	LAMP1	Lysosomal associated membrane protein 1. (465 aa)
	G3QJF9_GORGO	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
	CTCF	CCCTC-binding factor. (727 aa)
	CCR5	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
	STAT1	Signal transducer and activator of transcription. (777 aa)
	TAF1	Transcription initiation factor TFIID subunit. (1927 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CCR5	ENSGGOP00000007298	ENSGGOP00000051433	Angiotensin-converting enzyme.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.423
ACE2	CD4	ENSGGOP00000007298	ENSGGOP00000003173	Angiotensin-converting enzyme.	CD4 molecule.	0.702
ACE2	IFNG	ENSGGOP00000007298	ENSGGOP00000005908	Angiotensin-converting enzyme.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.531
ACE2	STAT3	ENSGGOP00000007298	ENSGGOP00000020538	Angiotensin-converting enzyme.	Signal transducer and activator of transcription.	0.465
CCR5	ACE2	ENSGGOP00000051433	ENSGGOP00000007298	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	Angiotensin-converting enzyme.	0.423
CCR5	CD4	ENSGGOP00000051433	ENSGGOP00000003173	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	CD4 molecule.	0.940
CCR5	CXCR4	ENSGGOP00000051433	ENSGGOP00000050507	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.932
CCR5	IFNG	ENSGGOP00000051433	ENSGGOP00000005908	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.773
CCR5	STAT1	ENSGGOP00000051433	ENSGGOP00000026987	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	Signal transducer and activator of transcription.	0.530
CCR5	STAT3	ENSGGOP00000051433	ENSGGOP00000020538	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	Signal transducer and activator of transcription.	0.547
CD4	ACE2	ENSGGOP00000003173	ENSGGOP00000007298	CD4 molecule.	Angiotensin-converting enzyme.	0.702
CD4	CCR5	ENSGGOP00000003173	ENSGGOP00000051433	CD4 molecule.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.940
CD4	CD63	ENSGGOP00000003173	ENSGGOP00000047084	CD4 molecule.	Tetraspanin.	0.479
CD4	CXCR4	ENSGGOP00000003173	ENSGGOP00000050507	CD4 molecule.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.952
CD4	ENSGGOP00000043564	ENSGGOP00000003173	ENSGGOP00000043564	CD4 molecule.	Interferon regulatory factor 3.	0.683
CD4	FYN	ENSGGOP00000003173	ENSGGOP00000007888	CD4 molecule.	Tyrosine-protein kinase.	0.465
CD4	G3QTI0_GORGO	ENSGGOP00000003173	ENSGGOP00000006004	CD4 molecule.	Signal transducer and activator of transcription.	0.489
CD4	IFITM1	ENSGGOP00000003173	ENSGGOP00000003322	CD4 molecule.	Interferon induced transmembrane protein 1.	0.452
CD4	IFNG	ENSGGOP00000003173	ENSGGOP00000005908	CD4 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.917
CD4	IRF1	ENSGGOP00000003173	ENSGGOP00000013588	CD4 molecule.	Interferon regulatory factor.	0.566