STRINGSTRING
IFI16 IFI16 STAT6 STAT6 TANK TANK TLR2 TLR2 TRAF6 TRAF6 TYK2 TYK2 IFNG IFNG AIM2 AIM2 G3QTI0_GORGO G3QTI0_GORGO OAS3 OAS3 OAS2 OAS2 DUSP11 DUSP11 G3R3U7_GORGO G3R3U7_GORGO HERC5 HERC5 IRF1 IRF1 DDX41 DDX41 G3RG63_GORGO G3RG63_GORGO IRF9 IRF9 JAK1 JAK1 G3RLN8_GORGO G3RLN8_GORGO IFNB1 IFNB1 IRAK1 IRAK1 RELB RELB RNASEL RNASEL G3RVS4_GORGO G3RVS4_GORGO STAT3 STAT3 TLR4 TLR4 SSR2 SSR2 G3S4N6_GORGO G3S4N6_GORGO TBK1 TBK1 CGAS CGAS OAS1 OAS1 STAT1 STAT1 TLR3 TLR3 RELA RELA ENSGGOP00000030478 ENSGGOP00000030478 IFNAR1 IFNAR1 STAT4 STAT4 ENSGGOP00000043564 ENSGGOP00000043564 IRF7 IRF7 ENSGGOP00000046758 ENSGGOP00000046758 ENSGGOP00000051931 ENSGGOP00000051931
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFI16Interferon gamma inducible protein 16. (785 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AIM2Absent in melanoma 2. (343 aa)
G3QTI0_GORGOSignal transducer and activator of transcription. (853 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1087 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
DUSP11Dual specificity phosphatase 11. (330 aa)
G3R3U7_GORGOMitochondrial antiviral signaling protein. (481 aa)
HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5. (1035 aa)
IRF1Interferon regulatory factor. (325 aa)
DDX41DEAD-box helicase 41. (622 aa)
G3RG63_GORGOISG15 ubiquitin like modifier. (165 aa)
IRF9Interferon regulatory factor 9. (392 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
G3RLN8_GORGOSignal transducer and activator of transcription. (652 aa)
IFNB1Interferon beta 1. (187 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
RELBRELB proto-oncogene, NF-kB subunit. (579 aa)
RNASELRibonuclease L. (741 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
SSR2Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (202 aa)
G3S4N6_GORGOMyeloid leukemia factor 1. (299 aa)
TBK1TANK binding kinase 1. (729 aa)
CGASCyclic GMP-AMP synthase. (447 aa)
OAS12'-5'-oligoadenylate synthetase 1. (414 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
ENSGGOP00000043564Interferon regulatory factor 3. (452 aa)
IRF7Interferon regulatory factor 7. (516 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
ENSGGOP00000051931Interferon gamma receptor 2. (356 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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