STRINGSTRING
ADIPOQ ADIPOQ CNP CNP EPO EPO NRG4 NRG4 HGF HGF FKBP6 FKBP6 PTEN PTEN FUT2 FUT2 FGF21 FGF21 RPS6 RPS6 KDM5B KDM5B G3QPQ9_GORGO G3QPQ9_GORGO CKMT2 CKMT2 BMP15 BMP15 CKB CKB SLC5A7 SLC5A7 G3R0C6_GORGO G3R0C6_GORGO GAPDH GAPDH SIRT1 SIRT1 MTOR MTOR GDF9 GDF9 FSHR FSHR KDM6B KDM6B HDAC7 HDAC7 G3RPR5_GORGO G3RPR5_GORGO PTGS2 PTGS2 UCP1 UCP1 IL6 IL6 HDAC5 HDAC5 TLR4 TLR4 SALL4 SALL4 AMH AMH TLR10 TLR10 ENSGGOP00000031463 ENSGGOP00000031463 G3S4D8_GORGO G3S4D8_GORGO ALB ALB HDAC9 HDAC9 HDAC4 HDAC4 ALOX15 ALOX15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
NRG4Neuregulin 4. (117 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (733 aa)
FKBP6Peptidylprolyl isomerase. (327 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FUT2Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host- microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen, which is an essential substrate for the final step in the membrane-associated blood group antigen synthesis pathway. (343 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
KDM5BPHD-type domain-containing protein. (194 aa)
G3QPQ9_GORGOUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
CKMT2Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (419 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
CKBPhosphagen kinase C-terminal domain-containing protein; Belongs to the ATP:guanido phosphotransferase family. (205 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
G3R0C6_GORGOCreatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
SIRT1Sirtuin 1. (751 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
GDF9Growth differentiation factor 9. (455 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
KDM6BLysine demethylase 6B. (1687 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
G3RPR5_GORGOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
IL6Interleukin 6. (234 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
AMHAnti-Mullerian hormone. (560 aa)
TLR10Toll-like receptor. (811 aa)
ENSGGOP00000031463Peptidylprolyl isomerase. (101 aa)
G3S4D8_GORGOLysine demethylase 6A. (1453 aa)
ALBAlbumin. (609 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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