STRINGSTRING
FOS FOS MYB MYB E2F1 E2F1 C16H16orf86 C16H16orf86 SAP30 SAP30 HDAC2 HDAC2 GATA2 GATA2 CDC5L CDC5L ZZZ3 ZZZ3 SIN3B SIN3B ESR1 ESR1 CBX2 CBX2 SUZ12 SUZ12 XRCC5 XRCC5 HDAC1 HDAC1 IRF1 IRF1 MYC MYC G3RXP9_GORGO G3RXP9_GORGO BRCA1 BRCA1 YY1 YY1 EZH2 EZH2 BMI1 BMI1 CASTOR1 CASTOR1 MIER1 MIER1 SIN3A SIN3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
E2F1E2F transcription factor 1. (437 aa)
C16H16orf86Chromosome 16 open reading frame 86. (317 aa)
SAP30Sin3A associated protein 30. (220 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
GATA2GATA binding protein 2. (480 aa)
CDC5LCell division cycle 5 like. (805 aa)
ZZZ3Uncharacterized protein. (903 aa)
SIN3BSIN3 transcription regulator family member B. (1153 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
CBX2Chromobox 2. (532 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (610 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
IRF1Interferon regulatory factor. (325 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
G3RXP9_GORGONuclear receptor subfamily 2 group F member 2. (414 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa)
YY1YY1 transcription factor. (414 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
BMI1RING-type domain-containing protein. (326 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (346 aa)
MIER1MIER1 transcriptional regulator. (509 aa)
SIN3AUncharacterized protein. (154 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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