node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMI1 | BRCA1 | ENSGGOP00000027591 | ENSGGOP00000023921 | RING-type domain-containing protein. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.741 |
BMI1 | CBX2 | ENSGGOP00000027591 | ENSGGOP00000009573 | RING-type domain-containing protein. | Chromobox 2. | 0.993 |
BMI1 | CDC5L | ENSGGOP00000027591 | ENSGGOP00000006644 | RING-type domain-containing protein. | Cell division cycle 5 like. | 0.607 |
BMI1 | E2F1 | ENSGGOP00000027591 | ENSGGOP00000003528 | RING-type domain-containing protein. | E2F transcription factor 1. | 0.502 |
BMI1 | EZH2 | ENSGGOP00000027591 | ENSGGOP00000024644 | RING-type domain-containing protein. | Enhancer of zeste 2 polycomb repressive complex 2 subunit. | 0.937 |
BMI1 | HDAC1 | ENSGGOP00000027591 | ENSGGOP00000011454 | RING-type domain-containing protein. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.469 |
BMI1 | HDAC2 | ENSGGOP00000027591 | ENSGGOP00000005320 | RING-type domain-containing protein. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.737 |
BMI1 | MIER1 | ENSGGOP00000027591 | ENSGGOP00000031785 | RING-type domain-containing protein. | MIER1 transcriptional regulator. | 0.657 |
BMI1 | MYC | ENSGGOP00000027591 | ENSGGOP00000018583 | RING-type domain-containing protein. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. | 0.688 |
BMI1 | SAP30 | ENSGGOP00000027591 | ENSGGOP00000004979 | RING-type domain-containing protein. | Sin3A associated protein 30. | 0.633 |
BMI1 | SIN3A | ENSGGOP00000027591 | ENSGGOP00000035548 | RING-type domain-containing protein. | Uncharacterized protein. | 0.400 |
BMI1 | SIN3B | ENSGGOP00000027591 | ENSGGOP00000009306 | RING-type domain-containing protein. | SIN3 transcription regulator family member B. | 0.658 |
BMI1 | SUZ12 | ENSGGOP00000027591 | ENSGGOP00000010105 | RING-type domain-containing protein. | SUZ12 polycomb repressive complex 2 subunit. | 0.926 |
BMI1 | XRCC5 | ENSGGOP00000027591 | ENSGGOP00000011192 | RING-type domain-containing protein. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.623 |
BMI1 | YY1 | ENSGGOP00000027591 | ENSGGOP00000024135 | RING-type domain-containing protein. | YY1 transcription factor. | 0.875 |
BMI1 | ZZZ3 | ENSGGOP00000027591 | ENSGGOP00000009035 | RING-type domain-containing protein. | Uncharacterized protein. | 0.677 |
BRCA1 | BMI1 | ENSGGOP00000023921 | ENSGGOP00000027591 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | RING-type domain-containing protein. | 0.741 |
BRCA1 | CBX2 | ENSGGOP00000023921 | ENSGGOP00000009573 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Chromobox 2. | 0.732 |
BRCA1 | E2F1 | ENSGGOP00000023921 | ENSGGOP00000003528 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | E2F transcription factor 1. | 0.663 |
BRCA1 | ESR1 | ENSGGOP00000023921 | ENSGGOP00000009454 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.981 |