(24 nodes) (2021) REST is a major negative regulator of endocrine differentiation during pancreas organogenesis. network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MAPK10	Mitogen-activated protein kinase. (551 aa)
	CDK2AP1	Uncharacterized protein. (133 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
	GLIS3	GLIS family zinc finger 3. (765 aa)
	CCND1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
	G3SJH8_GORGO	Uncharacterized protein. (596 aa)
	GCG	Glucagon. (180 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	MAPK3	Mitogen-activated protein kinase. (322 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	CDH13	Cadherin 13. (760 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	TBP	TATA-box binding protein. (332 aa)
	ISL1	ISL LIM homeobox 1. (351 aa)
	NKX6-1	NK6 homeobox 1. (367 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	CDK5R2	Uncharacterized protein. (95 aa)
	MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2. (847 aa)
	PCSK2	Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (638 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
	ONECUT1	One cut domain family member. (465 aa)
	PAX4	Paired box 4. (351 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCND1	MAPK11	ENSGGOP00000032889	ENSGGOP00000023054	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Mitogen-activated protein kinase.	0.499
CCND1	MAPK3	ENSGGOP00000032889	ENSGGOP00000021887	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Mitogen-activated protein kinase.	0.609
CCND1	TBP	ENSGGOP00000032889	ENSGGOP00000011550	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	TATA-box binding protein.	0.426
CDK2AP1	CDK5R2	ENSGGOP00000043572	ENSGGOP00000007597	Uncharacterized protein.	Uncharacterized protein.	0.440
CDK2AP1	MAPK11	ENSGGOP00000043572	ENSGGOP00000023054	Uncharacterized protein.	Mitogen-activated protein kinase.	0.422
CDK2AP1	ONECUT1	ENSGGOP00000043572	ENSGGOP00000004586	Uncharacterized protein.	One cut domain family member.	0.413
CDK2AP1	PCSK1	ENSGGOP00000043572	ENSGGOP00000006843	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.408
CDK2AP1	PCSK2	ENSGGOP00000043572	ENSGGOP00000007101	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.	0.437
CDK5R2	CDK2AP1	ENSGGOP00000007597	ENSGGOP00000043572	Uncharacterized protein.	Uncharacterized protein.	0.440
CDK5R2	MAPK11	ENSGGOP00000007597	ENSGGOP00000023054	Uncharacterized protein.	Mitogen-activated protein kinase.	0.414
CDK5R2	ONECUT1	ENSGGOP00000007597	ENSGGOP00000004586	Uncharacterized protein.	One cut domain family member.	0.408
CDK5R2	PCSK1	ENSGGOP00000007597	ENSGGOP00000006843	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.437
CDK5R2	PCSK2	ENSGGOP00000007597	ENSGGOP00000007101	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.	0.479
G3SJH8_GORGO	MAPK10	ENSGGOP00000028268	ENSGGOP00000051388	Uncharacterized protein.	Mitogen-activated protein kinase.	0.734
G3SJH8_GORGO	MAPK11	ENSGGOP00000028268	ENSGGOP00000023054	Uncharacterized protein.	Mitogen-activated protein kinase.	0.402
G3SJH8_GORGO	MAPK8IP2	ENSGGOP00000028268	ENSGGOP00000007124	Uncharacterized protein.	Mitogen-activated protein kinase 8 interacting protein 2.	0.895
GCG	INS	ENSGGOP00000026426	ENSGGOP00000034798	Glucagon.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.777
GCG	ISL1	ENSGGOP00000026426	ENSGGOP00000009362	Glucagon.	ISL LIM homeobox 1.	0.400
GCG	NEUROD1	ENSGGOP00000026426	ENSGGOP00000017698	Glucagon.	Neurogenic differentiation factor.	0.640
GCG	NKX2-2	ENSGGOP00000026426	ENSGGOP00000007897	Glucagon.	NK2 homeobox 2.	0.552