(12 nodes) (2021) In silico Characterization of the Heme Oxygenase 1 From Bottlenose Dolphin (Tursiops truncatus): Evidence of Changes in the Active Site and Purifying Selection. network (Gorilla gorilla)

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Your Input:
	G3QTI0_GORGO	Signal transducer and activator of transcription. (853 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (150 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	IRF9	Interferon regulatory factor 9. (392 aa)
	G3RSR8_GORGO	Haptoglobin; Belongs to the peptidase S1 family. (371 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	TLR10	Toll-like receptor. (811 aa)
	CYTB	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (289 aa)
	STAT1	Signal transducer and activator of transcription. (777 aa)
	NFE2	Nuclear factor, erythroid 2. (373 aa)
	CTCF	CCCTC-binding factor. (727 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTCF	STAT1	ENSGGOP00000001047	ENSGGOP00000026987	CCCTC-binding factor.	Signal transducer and activator of transcription.	0.449
CYTB	MB	ENSGGOP00000022734	ENSGGOP00000011193	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.778
G3QTI0_GORGO	IRF9	ENSGGOP00000006004	ENSGGOP00000015651	Signal transducer and activator of transcription.	Interferon regulatory factor 9.	0.998
G3QTI0_GORGO	STAT1	ENSGGOP00000006004	ENSGGOP00000026987	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.998
G3QTI0_GORGO	TLR10	ENSGGOP00000006004	ENSGGOP00000022546	Signal transducer and activator of transcription.	Toll-like receptor.	0.407
G3RSR8_GORGO	GPX2	ENSGGOP00000018843	ENSGGOP00000006471	Haptoglobin; Belongs to the peptidase S1 family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.443
G3RSR8_GORGO	HMOX1	ENSGGOP00000018843	ENSGGOP00000046026	Haptoglobin; Belongs to the peptidase S1 family.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.443
G3RSR8_GORGO	MB	ENSGGOP00000018843	ENSGGOP00000011193	Haptoglobin; Belongs to the peptidase S1 family.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.857
GPX2	G3RSR8_GORGO	ENSGGOP00000006471	ENSGGOP00000018843	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Haptoglobin; Belongs to the peptidase S1 family.	0.443
GPX2	HMOX1	ENSGGOP00000006471	ENSGGOP00000046026	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.647
GPX2	MB	ENSGGOP00000006471	ENSGGOP00000011193	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.467
HMOX1	G3RSR8_GORGO	ENSGGOP00000046026	ENSGGOP00000018843	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	Haptoglobin; Belongs to the peptidase S1 family.	0.443
HMOX1	GPX2	ENSGGOP00000046026	ENSGGOP00000006471	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.647
HMOX1	MB	ENSGGOP00000046026	ENSGGOP00000011193	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.492
HMOX1	NFE2	ENSGGOP00000046026	ENSGGOP00000002993	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	Nuclear factor, erythroid 2.	0.538
IRF9	G3QTI0_GORGO	ENSGGOP00000015651	ENSGGOP00000006004	Interferon regulatory factor 9.	Signal transducer and activator of transcription.	0.998
IRF9	STAT1	ENSGGOP00000015651	ENSGGOP00000026987	Interferon regulatory factor 9.	Signal transducer and activator of transcription.	0.999
MB	CYTB	ENSGGOP00000011193	ENSGGOP00000022734	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	0.778
MB	G3RSR8_GORGO	ENSGGOP00000011193	ENSGGOP00000018843	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Haptoglobin; Belongs to the peptidase S1 family.	0.857
MB	GPX2	ENSGGOP00000011193	ENSGGOP00000006471	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.467