(55 nodes) (2023) Different Contacted Cell Types Contribute to Acquiring Different Properties in Brain Microglial Cells upon Intercellular Interaction. network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AQP4	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (734 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	NFKBIA	NFKB inhibitor alpha. (317 aa)
	CCNB3	Cyclin B3; Belongs to the cyclin family. (1393 aa)
	CD86	CD86 molecule. (329 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (410 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (618 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
	HRK	Activator of apoptosis harakiri; Promotes apoptosis. (91 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	DIABLO	Uncharacterized protein. (166 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (853 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
	E2F1	E2F transcription factor 1. (437 aa)
	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B. (1068 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (433 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	MAPK10	Mitogen-activated protein kinase. (551 aa)
	ENSGGOP00000050973	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
	CDKN1B	Uncharacterized protein. (205 aa)
	CD163	CD163 molecule. (1156 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	ENSGGOP00000046735	Non-specific serine/threonine protein kinase. (524 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1094 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (250 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	TNFRSF21	TNF receptor superfamily member 21. (655 aa)
	ENSGGOP00000040478	Helicase, lymphoid specific. (884 aa)
	ENSGGOP00000039722	TNF receptor superfamily member 25. (426 aa)
	CD68	CD68 molecule. (354 aa)
	IRF6	Interferon regulatory factor 6. (467 aa)
	ENSGGOP00000032091	Caspase 4; Belongs to the peptidase C14A family. (377 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (465 aa)
	TMEM119	Transmembrane protein 119. (283 aa)
	CDC25A	Cell division cycle 25A. (524 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	CD80	CD80 molecule. (287 aa)
	FSCN1	Fascin. (493 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	SKP2	S-phase kinase associated protein 2. (425 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (292 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	CNN3	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (329 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	TNFRSF10B	TNF receptor superfamily member 10b. (440 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP4	MAPK10	ENSGGOP00000010219	ENSGGOP00000051388	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Mitogen-activated protein kinase.	0.446
BCL2	BIRC2	ENSGGOP00000000778	ENSGGOP00000008137	BCL2 apoptosis regulator.	Baculoviral IAP repeat containing 2.	0.537
BCL2	CASP3	ENSGGOP00000000778	ENSGGOP00000021659	BCL2 apoptosis regulator.	Caspase 3; Belongs to the peptidase C14A family.	0.868
BCL2	CASP6	ENSGGOP00000000778	ENSGGOP00000028537	BCL2 apoptosis regulator.	Caspase 6; Belongs to the peptidase C14A family.	0.558
BCL2	CCNA1	ENSGGOP00000000778	ENSGGOP00000026010	BCL2 apoptosis regulator.	Cyclin A1; Belongs to the cyclin family.	0.483
BCL2	CCNB1	ENSGGOP00000000778	ENSGGOP00000001503	BCL2 apoptosis regulator.	Cyclin B1; Belongs to the cyclin family.	0.541
BCL2	CCND2	ENSGGOP00000000778	ENSGGOP00000009259	BCL2 apoptosis regulator.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.675
BCL2	CCND3	ENSGGOP00000000778	ENSGGOP00000014792	BCL2 apoptosis regulator.	Cyclin D3; Belongs to the cyclin family.	0.436
BCL2	CCNE1	ENSGGOP00000000778	ENSGGOP00000008259	BCL2 apoptosis regulator.	Cyclin E1; Belongs to the cyclin family.	0.438
BCL2	CD68	ENSGGOP00000000778	ENSGGOP00000033924	BCL2 apoptosis regulator.	CD68 molecule.	0.483
BCL2	CDKN1B	ENSGGOP00000000778	ENSGGOP00000049641	BCL2 apoptosis regulator.	Uncharacterized protein.	0.513
BCL2	CFLAR	ENSGGOP00000000778	ENSGGOP00000010692	BCL2 apoptosis regulator.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.636
BCL2	DIABLO	ENSGGOP00000000778	ENSGGOP00000005240	BCL2 apoptosis regulator.	Uncharacterized protein.	0.715
BCL2	E2F1	ENSGGOP00000000778	ENSGGOP00000003528	BCL2 apoptosis regulator.	E2F transcription factor 1.	0.573
BCL2	ENSGGOP00000032091	ENSGGOP00000000778	ENSGGOP00000032091	BCL2 apoptosis regulator.	Caspase 4; Belongs to the peptidase C14A family.	0.428
BCL2	ENSGGOP00000039722	ENSGGOP00000000778	ENSGGOP00000039722	BCL2 apoptosis regulator.	TNF receptor superfamily member 25.	0.499
BCL2	ENSGGOP00000046735	ENSGGOP00000000778	ENSGGOP00000046735	BCL2 apoptosis regulator.	Non-specific serine/threonine protein kinase.	0.752
BCL2	ENSGGOP00000050973	ENSGGOP00000000778	ENSGGOP00000050973	BCL2 apoptosis regulator.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.589
BCL2	GSK3B	ENSGGOP00000000778	ENSGGOP00000007214	BCL2 apoptosis regulator.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.541
BCL2	HRK	ENSGGOP00000000778	ENSGGOP00000006022	BCL2 apoptosis regulator.	Activator of apoptosis harakiri; Promotes apoptosis.	0.905