33 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3R3U7_GORGO	Mitochondrial antiviral signaling protein. (481 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (724 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	IFI6	Interferon alpha inducible protein 6. (130 aa)
	APOL1	Apolipoprotein L1. (414 aa)
	CD69	CD69 molecule. (199 aa)
	CD86	CD86 molecule. (329 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	SECTM1	Secreted and transmembrane 1. (248 aa)
	CD4	CD4 molecule. (458 aa)
	IL6	Interleukin 6. (234 aa)
	ENSGGOP00000046758	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	ENSGGOP00000043564	Interferon regulatory factor 3. (452 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
	CD68	CD68 molecule. (354 aa)
	TLR3	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
	STAT1	Signal transducer and activator of transcription. (777 aa)
	CGAS	Cyclic GMP-AMP synthase. (447 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	CD40	CD40 molecule. (277 aa)
	SOX17	HMG box domain-containing protein. (184 aa)
	POU5F1	POU domain protein. (360 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	CD80	CD80 molecule. (287 aa)
	GATA1	GATA binding protein 1. (413 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	CGAS	ENSGGOP00000006002	ENSGGOP00000025666	Absent in melanoma 2.	Cyclic GMP-AMP synthase.	0.644
AIM2	ENSGGOP00000043564	ENSGGOP00000006002	ENSGGOP00000043564	Absent in melanoma 2.	Interferon regulatory factor 3.	0.558
AIM2	ENSGGOP00000046758	ENSGGOP00000006002	ENSGGOP00000046758	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.991
AIM2	G3R3U7_GORGO	ENSGGOP00000006002	ENSGGOP00000009929	Absent in melanoma 2.	Mitochondrial antiviral signaling protein.	0.585
AIM2	IFNG	ENSGGOP00000006002	ENSGGOP00000005908	Absent in melanoma 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.450
AIM2	IL6	ENSGGOP00000006002	ENSGGOP00000018546	Absent in melanoma 2.	Interleukin 6.	0.458
AIM2	IRF1	ENSGGOP00000006002	ENSGGOP00000013588	Absent in melanoma 2.	Interferon regulatory factor.	0.483
AIM2	IRF7	ENSGGOP00000006002	ENSGGOP00000043794	Absent in melanoma 2.	Interferon regulatory factor 7.	0.458
AIM2	MYD88	ENSGGOP00000006002	ENSGGOP00000003761	Absent in melanoma 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.463
AIM2	STAT1	ENSGGOP00000006002	ENSGGOP00000026987	Absent in melanoma 2.	Signal transducer and activator of transcription.	0.405
AIM2	TBK1	ENSGGOP00000006002	ENSGGOP00000024379	Absent in melanoma 2.	TANK binding kinase 1.	0.471
AIM2	TLR3	ENSGGOP00000006002	ENSGGOP00000027247	Absent in melanoma 2.	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	0.506
BMPR2	STAT3	ENSGGOP00000039642	ENSGGOP00000020538	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Signal transducer and activator of transcription.	0.533
CD4	CD40	ENSGGOP00000003173	ENSGGOP00000024263	CD4 molecule.	CD40 molecule.	0.751
CD4	CD68	ENSGGOP00000003173	ENSGGOP00000033924	CD4 molecule.	CD68 molecule.	0.524
CD4	CD69	ENSGGOP00000003173	ENSGGOP00000002507	CD4 molecule.	CD69 molecule.	0.834
CD4	CD80	ENSGGOP00000003173	ENSGGOP00000020172	CD4 molecule.	CD80 molecule.	0.812
CD4	CD86	ENSGGOP00000003173	ENSGGOP00000008390	CD4 molecule.	CD86 molecule.	0.766
CD4	CGAS	ENSGGOP00000003173	ENSGGOP00000025666	CD4 molecule.	Cyclic GMP-AMP synthase.	0.624
CD4	CXCL10	ENSGGOP00000003173	ENSGGOP00000010309	CD4 molecule.	C-X-C motif chemokine.	0.687