STRINGSTRING
JAG1 JAG1 NOTCH3 NOTCH3 MYL3 MYL3 MCM7 MCM7 DAB2 DAB2 MCM4 MCM4 SERPINE1 SERPINE1 PDGFRB PDGFRB NUF2 NUF2 GMNN GMNN HMMR HMMR PECAM1 PECAM1 FEN1 FEN1 COL1A1 COL1A1 TAGLN TAGLN FABP3 FABP3 G3RFV2_GORGO G3RFV2_GORGO CHAF1B CHAF1B CXCL12 CXCL12 TGFBI TGFBI SNAI1 SNAI1 TOP2A TOP2A CD34 CD34 APLNR APLNR TYMS TYMS FOXM1 FOXM1 ADGRG6 ADGRG6 CDH2 CDH2 COL15A1 COL15A1 CENPA CENPA CDH5 CDH5 FEN1-2 FEN1-2 KIF2C KIF2C CXCR1 CXCR1 SLC45A4 SLC45A4 RUNX1 RUNX1 ENSGGOP00000035777 ENSGGOP00000035777 ENSGGOP00000040788 ENSGGOP00000040788 APLN APLN ENSGGOP00000041668 ENSGGOP00000041668 CDH11 CDH11 TNNT2 TNNT2 BUB1 BUB1 MCM6 MCM6 PCDH17 PCDH17 CXCR4 CXCR4 VEGFC VEGFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NOTCH3Notch receptor 3. (2317 aa)
MYL3Myosin light chain 3. (195 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
DAB2DAB adaptor protein 2. (770 aa)
MCM4DNA helicase; Belongs to the MCM family. (861 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
NUF2NUF2 component of NDC80 kinetochore complex. (464 aa)
GMNNGeminin DNA replication inhibitor. (208 aa)
HMMRHyaluronan mediated motility receptor. (747 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
TAGLNTransgelin; Belongs to the calponin family. (205 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
G3RFV2_GORGOMyosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
CHAF1BChromatin assembly factor 1 subunit B. (559 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
TGFBITransforming growth factor beta induced. (693 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
CD34CD34 molecule. (385 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
TYMSThymidylate synthetase. (279 aa)
FOXM1Forkhead box M1. (763 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
COL15A1Uncharacterized protein. (1388 aa)
CENPACentromere protein A. (140 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
FEN1-2Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (559 aa)
CXCR1C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. (350 aa)
SLC45A4Solute carrier family 45 member 4. (809 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ENSGGOP00000035777Baculoviral IAP repeat containing 5. (165 aa)
ENSGGOP00000040788Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (184 aa)
APLNApelin. (77 aa)
ENSGGOP00000041668Fibroblast growth factor receptor. (808 aa)
CDH11Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins. (810 aa)
TNNT2Troponin T2, cardiac type. (298 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1094 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PCDH17Protocadherin 17. (1159 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (423 aa)
VEGFCPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (230 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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