26 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNFRSF10A	TNF receptor superfamily member 10a. (468 aa)
	ENSGGOP00000039722	TNF receptor superfamily member 25. (426 aa)
	DAPK1	Death associated protein kinase 1. (1397 aa)
	THOC1	THO complex 1. (660 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	ANK3	Ankyrin 3. (4378 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (902 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	TNFRSF10B	TNF receptor superfamily member 10b. (440 aa)
	TRADD	Death domain-containing protein. (251 aa)
	UNC5CL	Unc-5 family C-terminal like. (518 aa)
	UNC5C	Unc-5 netrin receptor C. (931 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	UNC5B	Unc-5 netrin receptor B. (945 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	ANK2	Ankyrin 2. (3957 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (455 aa)
	FAS	Fas cell surface death receptor. (340 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)
	TNFRSF11B	Death domain-containing protein. (301 aa)
	ANK1	Ankyrin 1. (1897 aa)
	UNC5D	Unc-5 netrin receptor D. (958 aa)
	TNFRSF21	TNF receptor superfamily member 21. (655 aa)
	UNC5A	Unc-5 netrin receptor A. (920 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK1	NFKB1	ENSGGOP00000037194	ENSGGOP00000018764	Ankyrin 1.	Nuclear factor kappa B subunit 1.	0.407
ANK2	ANK3	ENSGGOP00000022927	ENSGGOP00000003874	Ankyrin 2.	Ankyrin 3.	0.922
ANK2	NFKB1	ENSGGOP00000022927	ENSGGOP00000018764	Ankyrin 2.	Nuclear factor kappa B subunit 1.	0.406
ANK3	ANK2	ENSGGOP00000003874	ENSGGOP00000022927	Ankyrin 3.	Ankyrin 2.	0.922
ANK3	NFKB1	ENSGGOP00000003874	ENSGGOP00000018764	Ankyrin 3.	Nuclear factor kappa B subunit 1.	0.406
ANK3	NFKB2	ENSGGOP00000003874	ENSGGOP00000006827	Ankyrin 3.	Nuclear factor kappa B subunit 2.	0.401
CRADD	FADD	ENSGGOP00000021798	ENSGGOP00000020107	CASP2 and RIPK1 domain containing adaptor with death domain.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.791
CRADD	PIDD1	ENSGGOP00000021798	ENSGGOP00000029519	CASP2 and RIPK1 domain containing adaptor with death domain.	P53-induced death domain protein 1.	0.999
CRADD	RIPK1	ENSGGOP00000021798	ENSGGOP00000012277	CASP2 and RIPK1 domain containing adaptor with death domain.	Receptor interacting serine/threonine kinase 1.	0.592
CRADD	TNFRSF1A	ENSGGOP00000021798	ENSGGOP00000027054	CASP2 and RIPK1 domain containing adaptor with death domain.	TNF receptor superfamily member 1A.	0.485
CRADD	TRADD	ENSGGOP00000021798	ENSGGOP00000011592	CASP2 and RIPK1 domain containing adaptor with death domain.	Death domain-containing protein.	0.790
DAPK1	FADD	ENSGGOP00000000085	ENSGGOP00000020107	Death associated protein kinase 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.793
DAPK1	UNC5B	ENSGGOP00000000085	ENSGGOP00000020754	Death associated protein kinase 1.	Unc-5 netrin receptor B.	0.718
ENSGGOP00000039722	FADD	ENSGGOP00000039722	ENSGGOP00000020107	TNF receptor superfamily member 25.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.831
ENSGGOP00000039722	FAS	ENSGGOP00000039722	ENSGGOP00000027099	TNF receptor superfamily member 25.	Fas cell surface death receptor.	0.465
ENSGGOP00000039722	RIPK1	ENSGGOP00000039722	ENSGGOP00000012277	TNF receptor superfamily member 25.	Receptor interacting serine/threonine kinase 1.	0.776
ENSGGOP00000039722	TNFRSF10A	ENSGGOP00000039722	ENSGGOP00000046895	TNF receptor superfamily member 25.	TNF receptor superfamily member 10a.	0.940
ENSGGOP00000039722	TNFRSF1A	ENSGGOP00000039722	ENSGGOP00000027054	TNF receptor superfamily member 25.	TNF receptor superfamily member 1A.	0.590
ENSGGOP00000039722	TNFRSF21	ENSGGOP00000039722	ENSGGOP00000040888	TNF receptor superfamily member 25.	TNF receptor superfamily member 21.	0.591
ENSGGOP00000039722	TRADD	ENSGGOP00000039722	ENSGGOP00000011592	TNF receptor superfamily member 25.	Death domain-containing protein.	0.923