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TNFRSF10A TNFRSF10A ENSGGOP00000039722 ENSGGOP00000039722 DAPK1 DAPK1 THOC1 THOC1 MYD88 MYD88 ANK3 ANK3 NFKB2 NFKB2 NGFR NGFR TNFRSF10B TNFRSF10B TRADD TRADD UNC5CL UNC5CL UNC5C UNC5C RIPK1 RIPK1 NFKB1 NFKB1 FADD FADD UNC5B UNC5B CRADD CRADD ANK2 ANK2 TNFRSF1A TNFRSF1A FAS FAS PIDD1 PIDD1 TNFRSF11B TNFRSF11B ANK1 ANK1 UNC5D UNC5D TNFRSF21 TNFRSF21 UNC5A UNC5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
ENSGGOP00000039722TNF receptor superfamily member 25. (426 aa)
DAPK1Death associated protein kinase 1. (1397 aa)
THOC1THO complex 1. (660 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
ANK3Ankyrin 3. (4378 aa)
NFKB2Nuclear factor kappa B subunit 2. (902 aa)
NGFRNerve growth factor receptor. (427 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
TRADDDeath domain-containing protein. (251 aa)
UNC5CLUnc-5 family C-terminal like. (518 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
ANK2Ankyrin 2. (3957 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FASFas cell surface death receptor. (340 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
TNFRSF11BDeath domain-containing protein. (301 aa)
ANK1Ankyrin 1. (1897 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
UNC5AUnc-5 netrin receptor A. (920 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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