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IL1RAPL1 IL1RAPL1 IL1RAPL2 IL1RAPL2 IL18R1 IL18R1 IL1RL1 IL1RL1 IL18RAP IL18RAP MYD88 MYD88 IL1RL2 IL1RL2 IL1R1 IL1R1 TLR2 TLR2 TLR10 TLR10 TLR3 TLR3 TLR4 TLR4 ENSGGOP00000021036 ENSGGOP00000021036 IL1RAP IL1RAP SARM1 SARM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (696 aa)
IL1RAPL2Interleukin 1 receptor accessory protein like 2. (686 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
IL18RAPInterleukin 18 receptor accessory protein. (599 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
IL1RL2Interleukin 1 receptor like 2. (575 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TLR10Toll-like receptor. (811 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
ENSGGOP00000021036annotation not available (839 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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