STRINGSTRING
GSTO2 GSTO2 BCL2 BCL2 XPA XPA CASP9 CASP9 G3QKY6_GORGO G3QKY6_GORGO ERBB2 ERBB2 MGST2 MGST2 GSTO1 GSTO1 GSTA4 GSTA4 PMAIP1 PMAIP1 BIRC3 BIRC3 MGST1 MGST1 MSH2 MSH2 AKT3 AKT3 BIRC2 BIRC2 XIAP XIAP GSTT2B GSTT2B PIK3CA PIK3CA PIK3CB PIK3CB GSTM3 GSTM3 BAX BAX ATM ATM G3R4P4_GORGO G3R4P4_GORGO BID BID GSTM5 GSTM5 MGST3 MGST3 ATP7B ATP7B MLH1 MLH1 G3RQE7_GORGO G3RQE7_GORGO ABCC2 ABCC2 CDKN1A CDKN1A BAK1 BAK1 MSH6 MSH6 PIK3R3 PIK3R3 FADD FADD BCL2L1 BCL2L1 TOP2B TOP2B CASP3 CASP3 MAPK3 MAPK3 ATP7A ATP7A MAP3K5 MAP3K5 TOP2A TOP2A BRCA1 BRCA1 GSTM1 GSTM1 PDPK1 PDPK1 FASLG FASLG GSTP1 GSTP1 FAS FAS CYCS CYCS G3SKC3_GORGO G3SKC3_GORGO TP53 TP53 CDKN2A CDKN2A AKT2 AKT2 APAF1 APAF1 ERCC1 ERCC1 BAD BAD MAPK1 MAPK1 POLH POLH ENSGGOP00000041700 ENSGGOP00000041700 ENSGGOP00000043235 ENSGGOP00000043235 SLC31A1 SLC31A1 ENSGGOP00000049412 ENSGGOP00000049412 PIK3R1 PIK3R1 BBC3 BBC3 GSTM4 GSTM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
G3QKY6_GORGOGlutathione S-transferase alpha 5; Belongs to the GST superfamily. (193 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (241 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
PMAIP1Uncharacterized protein. (150 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
XIAPUncharacterized protein. (371 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (244 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
GSTM3Glutathione S-transferase. (225 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
G3R4P4_GORGOUncharacterized protein. (240 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
GSTM5Glutathione S-transferase. (218 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
ATP7BATPase copper transporting beta. (1470 aa)
MLH1MutL homolog 1. (756 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ABCC2ATP binding cassette subfamily C member 2. (1545 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
PIK3R3Uncharacterized protein. (507 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BCL2L1BCL2 like 1. (233 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1562 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa)
GSTM1Glutathione S-transferase. (218 aa)
PDPK1Protein kinase domain-containing protein. (347 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
FASFas cell surface death receptor. (340 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
G3SKC3_GORGOGlutathione S-transferase alpha 2. (222 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (167 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
POLHUmuC domain-containing protein. (415 aa)
ENSGGOP00000041700GST N-terminal domain-containing protein. (67 aa)
ENSGGOP00000043235GST N-terminal domain-containing protein. (67 aa)
SLC31A1Solute carrier family 31 member 1. (190 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
BBC3Uncharacterized protein. (101 aa)
GSTM4Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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