STRINGSTRING
TRAM1L1 TRAM1L1 HSPBP1 HSPBP1 ERLEC1 ERLEC1 DNAJB12 DNAJB12 BCL2 BCL2 DERL3 DERL3 SEC23A SEC23A DNAJC3 DNAJC3 UBE2D3 UBE2D3 EIF2S1 EIF2S1 CKAP4 CKAP4 DDIT3 DDIT3 EDEM1 EDEM1 UBQLN3 UBQLN3 SEC24D SEC24D RAD23B RAD23B SEC63 SEC63 LMAN1L LMAN1L SYVN1 SYVN1 NGLY1 NGLY1 EDEM3 EDEM3 VCP VCP G3QL18_GORGO G3QL18_GORGO WFS1 WFS1 SEC61B SEC61B SSR1 SSR1 MARCHF6 MARCHF6 HERPUD1 HERPUD1 BCAP31 BCAP31 SEC61G SEC61G SEC24C SEC24C YOD1 YOD1 ERN1 ERN1 LMAN1 LMAN1 DNAJA1 DNAJA1 MAN1A1 MAN1A1 HYOU1 HYOU1 CANX CANX PRKCSH PRKCSH HSP90AB1 HSP90AB1 DERL1 DERL1 RRBP1 RRBP1 FBXO44 FBXO44 STT3A STT3A ATF4 ATF4 SEC13 SEC13 SEL1L2 SEL1L2 BAX BAX SEC61A1 SEC61A1 MBTPS1 MBTPS1 UGGT2 UGGT2 SEC24A SEC24A MAN1C1 MAN1C1 DNAJC5G DNAJC5G EIF2AK3 EIF2AK3 DNAJC1 DNAJC1 MBTPS2 MBTPS2 G3R8R1_GORGO G3R8R1_GORGO EDEM2 EDEM2 STT3B STT3B UBE2J1 UBE2J1 NSFL1C NSFL1C GANAB GANAB ATF6 ATF6 MAN1A2 MAN1A2 TUSC3 TUSC3 DNAJC5B DNAJC5B SEC31B SEC31B SVIP SVIP CALR CALR EIF2AK1 EIF2AK1 UBQLN1 UBQLN1 PLAA PLAA UBQLN2 UBQLN2 ERO1B ERO1B UBE2D2 UBE2D2 RNF5 RNF5 HSPA4L HSPA4L BAK1 BAK1 EIF2AK2 EIF2AK2 DNAJA2 DNAJA2 ERO1A ERO1A BAG2 BAG2 FBXO2 FBXO2 PREB PREB SAR1B SAR1B PDIA4 PDIA4 HSPA8 HSPA8 SKP1 SKP1 SEC24B SEC24B SSR2 SSR2 HSPH1 HSPH1 MAP3K5 MAP3K5 G3S4Z2_GORGO G3S4Z2_GORGO MAPK9 MAPK9 HSPA5 HSPA5 SAR1A SAR1A EIF2AK4 EIF2AK4 UBXN4 UBXN4 RNF185 RNF185 G3S9G1_GORGO G3S9G1_GORGO CAPN1 CAPN1 HSP90B1 HSP90B1 P4HB P4HB PDIA3 PDIA3 LMAN2 LMAN2 NPLOC4 NPLOC4 MAN1B1 MAN1B1 SEC23B SEC23B UFD1 UFD1 DNAJB1 DNAJB1 SSR3 SSR3 SEL1L SEL1L SELENOS SELENOS ENSGGOP00000031121 ENSGGOP00000031121 SEC61A2 SEC61A2 DNAJC5 DNAJC5 DDOST DDOST DERL2 DERL2 MOGS MOGS SEC62 SEC62 NFE2L2 NFE2L2 DAD1 DAD1 UBE4B UBE4B UBE2D1 UBE2D1 UGGT1 UGGT1 DNAJB2 DNAJB2 ATXN3 ATXN3 ATF6B ATF6B PRKN PRKN XBP1 XBP1 UBXN6 UBXN6 UBQLN4 UBQLN4 OS9 OS9 UBXN1 UBXN1 UBE2G2 UBE2G2 MAP2K7 MAP2K7 DNAJC10 DNAJC10 CUL1 CUL1 CRYAB CRYAB RPN1 RPN1 RPN2 RPN2 UBXN8 UBXN8 AMFR AMFR ENSGGOP00000046510 ENSGGOP00000046510 ERP29 ERP29 SIL1 SIL1 MAPK8 MAPK8 DNAJB11 DNAJB11 UBE2D4 UBE2D4 SSR4 SSR4 PDIA6 PDIA6 MAPK10 MAPK10 TXNDC5 TXNDC5 UBE2G1 UBE2G1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAM1L1Translocating chain-associated membrane protein; Belongs to the TRAM family. (369 aa)
HSPBP1HSPA (Hsp70) binding protein 1. (361 aa)
ERLEC1Endoplasmic reticulum lectin 1. (483 aa)
DNAJB12DnaJ heat shock protein family (Hsp40) member B12. (409 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (235 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
CKAP4Cytoskeleton associated protein 4. (523 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (657 aa)
UBQLN3Ubiquilin 3. (655 aa)
SEC24DSEC24 homolog D, COPII coat complex component. (1033 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
SEC63SEC63 homolog, protein translocation regulator. (674 aa)
LMAN1LLectin, mannose binding 1 like. (526 aa)
SYVN1Synoviolin 1. (617 aa)
NGLY1N-glycanase 1. (655 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (932 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
G3QL18_GORGOUncharacterized protein. (453 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
SSR1Signal sequence receptor subunit 1. (298 aa)
MARCHF6Membrane associated ring-CH-type finger 6. (910 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (391 aa)
BCAP31B cell receptor associated protein 31. (313 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
SEC24CUncharacterized protein. (1094 aa)
YOD1YOD1 deubiquitinase. (348 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
LMAN1Lectin, mannose binding 1. (510 aa)
DNAJA1DnaJ heat shock protein family (Hsp40) member A1. (397 aa)
MAN1A1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (579 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
CANXCalnexin. (592 aa)
PRKCSHProtein kinase C substrate 80K-H. (535 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
RRBP1Rib_recp_KP_reg domain-containing protein. (1540 aa)
FBXO44F-box protein 6. (293 aa)
STT3ASTT3 oligosaccharyltransferase complex catalytic subunit A. (705 aa)
ATF4Activating transcription factor 4. (351 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
SEL1L2SEL1L2 adaptor subunit of ERAD E3 ligase. (688 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (482 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1052 aa)
UGGT2UDP-glucose glycoprotein glucosyltransferase 2. (1516 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1093 aa)
MAN1C1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (630 aa)
DNAJC5GJ domain-containing protein. (179 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
DNAJC1DnaJ heat shock protein family (Hsp40) member C1. (510 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (520 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (505 aa)
STT3BSTT3 oligosaccharyltransferase complex catalytic subunit B. (721 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
NSFL1CNSFL1 cofactor. (372 aa)
GANABGlucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. (966 aa)
ATF6Activating transcription factor 6. (670 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
TUSC3Tumor suppressor candidate 3. (348 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
SEC31BSEC31 homolog B, COPII coat complex component. (1166 aa)
SVIPSmall VCP interacting protein. (77 aa)
CALRCalreticulin. (417 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa)
UBQLN1Ubiquilin 1. (589 aa)
PLAAUncharacterized protein. (609 aa)
UBQLN2Ubiquilin 2. (624 aa)
ERO1BEndoplasmic reticulum oxidoreductase 1 beta. (467 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
RNF5Ring finger protein 5. (180 aa)
HSPA4LHeat shock protein family A (Hsp70) member 4 like. (814 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
DNAJA2DnaJ heat shock protein family (Hsp40) member A2. (412 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
BAG2BCL2 associated athanogene 2. (211 aa)
FBXO2F-box protein 2. (295 aa)
PREBProlactin regulatory element binding. (417 aa)
SAR1BUncharacterized protein. (130 aa)
PDIA4Protein disulfide-isomerase A4. (645 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1248 aa)
SSR2Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (202 aa)
HSPH1Heat shock protein family H (Hsp110) member 1. (858 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
G3S4Z2_GORGOUncharacterized protein. (119 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
UBXN4UBX domain protein 4. (508 aa)
RNF185Ring finger protein 185. (192 aa)
G3S9G1_GORGOHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (729 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
P4HBProtein disulfide-isomerase. (508 aa)
PDIA3Protein disulfide-isomerase. (383 aa)
LMAN2L-type lectin-like domain-containing protein. (356 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (608 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa)
SEC23BProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (308 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (340 aa)
SSR3Signal sequence receptor subunit 3. (185 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
SELENOSUncharacterized protein. (218 aa)
ENSGGOP00000031121Uncharacterized protein. (361 aa)
SEC61A2SEC61 translocon alpha 2 subunit. (482 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
DDOSTDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (444 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
MOGSMannosyl-oligosaccharide glucosidase. (837 aa)
SEC62SEC62 homolog, preprotein translocation factor. (400 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
DAD1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa)
UBE4BUbiquitination factor E4B. (1302 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
UGGT1UDP-glucose glycoprotein glucosyltransferase 1. (1541 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (324 aa)
ATXN3Ataxin 3. (366 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
XBP1BZIP domain-containing protein. (380 aa)
UBXN6UBX domain protein 6. (477 aa)
UBQLN4Uncharacterized protein. (587 aa)
OS9OS9 endoplasmic reticulum lectin. (730 aa)
UBXN1UBX domain protein 1. (310 aa)
UBE2G2Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
DNAJC10DnaJ heat shock protein family (Hsp40) member C10. (810 aa)
CUL1Cullin domain-containing protein; Belongs to the cullin family. (323 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
RPN1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (630 aa)
RPN2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (658 aa)
UBXN8UBX domain-containing protein. (309 aa)
AMFRAutocrine motility factor receptor. (639 aa)
ENSGGOP00000046510Uncharacterized protein; Belongs to the SKP1 family. (164 aa)
ERP29Endoplasmic reticulum protein 29. (302 aa)
SIL1SIL1 nucleotide exchange factor. (468 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DNAJB11J domain-containing protein. (373 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
SSR4Signal sequence receptor subunit 4. (184 aa)
PDIA6Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (461 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
TXNDC5Uncharacterized protein; Belongs to the protein disulfide isomerase family. (361 aa)
UBE2G1Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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