STRINGSTRING
SPTA1 SPTA1 FOS FOS BCL2 BCL2 LMNA LMNA IL3 IL3 CTSB CTSB EIF2S1 EIF2S1 PRF1 PRF1 CASP9 CASP9 DDIT3 DDIT3 CTSC CTSC TRAF1 TRAF1 PARP4 PARP4 CASP2 CASP2 MAP2K1 MAP2K1 MAP3K14 MAP3K14 IKBKG IKBKG GADD45G GADD45G DIABLO DIABLO PMAIP1 PMAIP1 ITPR1 ITPR1 BIRC3 BIRC3 HRK HRK HTRA2 HTRA2 ERN1 ERN1 IKBKB IKBKB AKT3 AKT3 BIRC2 BIRC2 SEPTIN4 SEPTIN4 XIAP XIAP G3R0F2_GORGO G3R0F2_GORGO CHUK CHUK PIK3CA PIK3CA NFKBIA NFKBIA PIK3CB PIK3CB ATF4 ATF4 BAX BAX ATM ATM BID BID GADD45A GADD45A CTSW CTSW CFLAR CFLAR TNFRSF10B TNFRSF10B EIF2AK3 EIF2AK3 TRADD TRADD G3R8R1_GORGO G3R8R1_GORGO CTSH CTSH CASP10 CASP10 PARP3 PARP3 RIPK1 RIPK1 DFFA DFFA G3RB29_GORGO G3RB29_GORGO DFFB DFFB ACTG1 ACTG1 ENDOG ENDOG TP53AIP1 TP53AIP1 MCL1 MCL1 CTSO CTSO CTSZ CTSZ PTPN13 PTPN13 G3RMA0_GORGO G3RMA0_GORGO G3RQE7_GORGO G3RQE7_GORGO G3RQF7_GORGO G3RQF7_GORGO PARP2 PARP2 NFKB1 NFKB1 BAK1 BAK1 PIK3R3 PIK3R3 FADD FADD LMNB1 LMNB1 BCL2L1 BCL2L1 CASP3 CASP3 CTSK CTSK MAPK3 MAPK3 GADD45B GADD45B MAP3K5 MAP3K5 TUBA3C TUBA3C MAPK9 MAPK9 TUBAL3 TUBAL3 CAPN1 CAPN1 PDPK1 PDPK1 FASLG FASLG ITPR3 ITPR3 PARP1 PARP1 DAXX DAXX G3SEM1_GORGO G3SEM1_GORGO TNFRSF1A TNFRSF1A FAS FAS RAF1 RAF1 RELA RELA CYCS CYCS CASP6 CASP6 TUBA8 TUBA8 PIDD1 PIDD1 SPTAN1 SPTAN1 TP53 TP53 DAB2IP DAB2IP ENSGGOP00000032596 ENSGGOP00000032596 NRAS NRAS AKT2 AKT2 NGF NGF BCL2A1 BCL2A1 APAF1 APAF1 TUBA4A TUBA4A HRAS HRAS ITPR2 ITPR2 BAD BAD NTRK1 NTRK1 MAPK1 MAPK1 CSF2RB CSF2RB CASP7 CASP7 ENSGGOP00000045882 ENSGGOP00000045882 CTSV CTSV TNFRSF10A TNFRSF10A BCL2L11 BCL2L11 MAPK8 MAPK8 ENSGGOP00000049412 ENSGGOP00000049412 PIK3R1 PIK3R1 BBC3 BBC3 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPTA1Spectrin alpha, erythrocytic 1. (2419 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PRF1Perforin 1. (555 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
TRAF1TNF receptor-associated factor. (416 aa)
PARP4Poly [ADP-ribose] polymerase. (1691 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
DIABLOUncharacterized protein. (166 aa)
PMAIP1Uncharacterized protein. (150 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2706 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
HRKActivator of apoptosis harakiri; Promotes apoptosis. (91 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
SEPTIN4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (1012 aa)
XIAPUncharacterized protein. (371 aa)
G3R0F2_GORGOMitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ATF4Activating transcription factor 4. (351 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (376 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
TRADDDeath domain-containing protein. (251 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
PARP3Poly [ADP-ribose] polymerase. (538 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
G3RB29_GORGOGranzyme B; Belongs to the peptidase S1 family. (247 aa)
DFFBDNA fragmentation factor subunit beta. (338 aa)
ACTG1Actin gamma 1. (375 aa)
ENDOGEndonuclease. (297 aa)
TP53AIP1Tumor protein p53 regulated apoptosis inducing protein 1. (124 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (321 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
PTPN13Protein tyrosine phosphatase non-receptor type 13. (2490 aa)
G3RMA0_GORGOTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
G3RQF7_GORGOTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3R3Uncharacterized protein. (507 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
BCL2L1BCL2 like 1. (233 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
TUBA3CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (729 aa)
PDPK1Protein kinase domain-containing protein. (347 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
DAXXDeath domain associated protein. (743 aa)
G3SEM1_GORGOCathepsin L; Belongs to the peptidase C1 family. (333 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FASFas cell surface death receptor. (340 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2498 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
BCL2A1BCL2 related protein A1. (196 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa)
BADBCL2 associated agonist of cell death. (168 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (904 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
ENSGGOP00000045882Actin beta. (378 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (334 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
BBC3Uncharacterized protein. (101 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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