STRINGSTRING
BCL2 BCL2 BECN1 BECN1 CASP9 CASP9 DIABLO DIABLO PMAIP1 PMAIP1 BIRC3 BIRC3 HTRA2 HTRA2 BIRC8 BIRC8 BECN2 BECN2 BIRC2 BIRC2 BIRC7 BIRC7 SEPTIN4 SEPTIN4 NGFR NGFR XIAP XIAP BAX BAX BID BID G3RQE7_GORGO G3RQE7_GORGO BAK1 BAK1 FADD FADD BCL2L1 BCL2L1 CASP3 CASP3 MAPK9 MAPK9 TNFRSF1A TNFRSF1A CYCS CYCS APAF1 APAF1 CASP7 CASP7 BOK BOK BCL2L11 BCL2L11 BIRC6 BIRC6 MAPK8 MAPK8 ENSGGOP00000049412 ENSGGOP00000049412 BBC3 BBC3 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2BCL2 apoptosis regulator. (239 aa)
BECN1Beclin 1. (450 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
DIABLOUncharacterized protein. (166 aa)
PMAIP1Uncharacterized protein. (150 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
BIRC8Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
BECN2Beclin 2. (431 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
SEPTIN4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (1012 aa)
NGFRNerve growth factor receptor. (427 aa)
XIAPUncharacterized protein. (371 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BCL2L1BCL2 like 1. (233 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
BIRC6Baculoviral IAP repeat containing 6. (4883 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
BBC3Uncharacterized protein. (101 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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