node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BAK1 | ENSGGOP00000035421 | ENSGGOP00000018898 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 antagonist/killer 1. | 0.633 |
APAF1 | BAX | ENSGGOP00000035421 | ENSGGOP00000010113 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 associated X, apoptosis regulator. | 0.611 |
APAF1 | BBC3 | ENSGGOP00000035421 | ENSGGOP00000050504 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein. | 0.467 |
APAF1 | BCL2 | ENSGGOP00000035421 | ENSGGOP00000000778 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 apoptosis regulator. | 0.913 |
APAF1 | BCL2L1 | ENSGGOP00000035421 | ENSGGOP00000020778 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 like 1. | 0.895 |
APAF1 | BCL2L11 | ENSGGOP00000035421 | ENSGGOP00000047932 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. | 0.688 |
APAF1 | BID | ENSGGOP00000035421 | ENSGGOP00000010297 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.446 |
APAF1 | BIRC2 | ENSGGOP00000035421 | ENSGGOP00000008137 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 2. | 0.796 |
APAF1 | BIRC3 | ENSGGOP00000035421 | ENSGGOP00000005705 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 3. | 0.758 |
APAF1 | BIRC6 | ENSGGOP00000035421 | ENSGGOP00000049108 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 6. | 0.875 |
APAF1 | BIRC7 | ENSGGOP00000035421 | ENSGGOP00000008152 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 7. | 0.729 |
APAF1 | BIRC8 | ENSGGOP00000035421 | ENSGGOP00000007398 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | 0.849 |
APAF1 | BOK | ENSGGOP00000035421 | ENSGGOP00000045611 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 family apoptosis regulator BOK. | 0.602 |
APAF1 | CASP3 | ENSGGOP00000035421 | ENSGGOP00000021659 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 3; Belongs to the peptidase C14A family. | 0.995 |
APAF1 | CASP7 | ENSGGOP00000035421 | ENSGGOP00000045233 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 7; Belongs to the peptidase C14A family. | 0.895 |
APAF1 | CASP9 | ENSGGOP00000035421 | ENSGGOP00000001932 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 9; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CYCS | ENSGGOP00000035421 | ENSGGOP00000028382 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.999 |
APAF1 | DIABLO | ENSGGOP00000035421 | ENSGGOP00000005240 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein. | 0.914 |
APAF1 | ENSGGOP00000049412 | ENSGGOP00000035421 | ENSGGOP00000049412 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.986 |
APAF1 | FADD | ENSGGOP00000035421 | ENSGGOP00000020107 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.646 |