STRINGSTRING
BCL2 BCL2 STAT6 STAT6 G3QH59_GORGO G3QH59_GORGO VDAC3 VDAC3 SMPD1 SMPD1 CHMP7 CHMP7 HIST2H2AA3 HIST2H2AA3 H2AC20 H2AC20 G3QKC9_GORGO G3QKC9_GORGO TNFAIP3 TNFAIP3 IL1A IL1A RIPK3 RIPK3 NLRP3 NLRP3 BIRC3 BIRC3 G3QT16_GORGO G3QT16_GORGO TYK2 TYK2 IFNG IFNG IL1B IL1B VPS4B VPS4B SP100 SP100 G3QXY3_GORGO G3QXY3_GORGO G3QYE9_GORGO G3QYE9_GORGO BIRC2 BIRC2 CYLD CYLD IFNGR1 IFNGR1 XIAP XIAP HSP90AB1 HSP90AB1 RBCK1 RBCK1 BAX BAX BID BID VDAC1 VDAC1 SPATA2L SPATA2L CFLAR CFLAR ZBP1 ZBP1 TNFRSF10B TNFRSF10B PLA2G4E PLA2G4E TRADD TRADD PLA2G4A PLA2G4A RIPK1 RIPK1 PYGM PYGM PPID PPID TRAF5 TRAF5 FAF1 FAF1 SLC25A31 SLC25A31 SLC25A5 SLC25A5 PYGB PYGB GLUD1 GLUD1 RNF31 RNF31 IRF9 IRF9 JAK1 JAK1 CHMP5 CHMP5 CHMP4C CHMP4C PYCARD PYCARD IFNB1 IFNB1 G3RM71_GORGO G3RM71_GORGO FTH1 FTH1 PYGL PYGL HIST1H2AK HIST1H2AK CHMP2B CHMP2B G3RQE0_GORGO G3RQE0_GORGO PGAM5 PGAM5 EIF2AK2 EIF2AK2 G3RVS4_GORGO G3RVS4_GORGO PPIA PPIA FADD FADD SQSTM1 SQSTM1 CHMP4B-2 CHMP4B-2 STAT3 STAT3 SHARPIN SHARPIN TLR4 TLR4 PLA2G4F PLA2G4F G3S148_GORGO G3S148_GORGO IFNA2 IFNA2 G3S4Z2_GORGO G3S4Z2_GORGO G3S4Z9_GORGO G3S4Z9_GORGO MAPK9 MAPK9 TICAM2 TICAM2 CHMP2A CHMP2A SPATA2 SPATA2 CAPN1 CAPN1 FASLG FASLG PARP1 PARP1 TRPM7 TRPM7 STAT1 STAT1 TNFRSF1A TNFRSF1A FAS FAS HMGB1 HMGB1 TLR3 TLR3 ALOX15 ALOX15 G3SHJ3_GORGO G3SHJ3_GORGO GLUL GLUL ENSGGOP00000029461 ENSGGOP00000029461 ENSGGOP00000029696 ENSGGOP00000029696 CAMK2A CAMK2A ENSGGOP00000031121 ENSGGOP00000031121 CAMK2B CAMK2B IFNAR1 IFNAR1 MLKL MLKL ENSGGOP00000035522 ENSGGOP00000035522 G3RKB0_GORGO G3RKB0_GORGO VDAC2 VDAC2 ENSGGOP00000038183 ENSGGOP00000038183 SLC25A4 SLC25A4 CHMP6 CHMP6 IL33 IL33 STAT4 STAT4 IFNA13 IFNA13 GLUD2 GLUD2 ENSGGOP00000046758 ENSGGOP00000046758 TNFRSF10A TNFRSF10A FTL FTL VPS4A VPS4A MAPK8 MAPK8 IFNAR2 IFNAR2 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2BCL2 apoptosis regulator. (239 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
G3QH59_GORGOCore histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
HIST2H2AA3Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
G3QKC9_GORGOHistone H2A; Belongs to the histone H2A family. (130 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
NLRP3NLR family pyrin domain containing 3. (1028 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
G3QT16_GORGOCore histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
SP100Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (209 aa)
G3QXY3_GORGOCytochrome b-245 beta chain. (570 aa)
G3QYE9_GORGOHistone H2A; Belongs to the histone H2A family. (143 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
XIAPUncharacterized protein. (371 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
RBCK1Uncharacterized protein. (204 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
VDAC1Voltage dependent anion channel 1. (289 aa)
SPATA2LSpermatogenesis associated 2 like. (424 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ZBP1Z-DNA binding protein 1. (429 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
PLA2G4EPhospholipase A2. (868 aa)
TRADDDeath domain-containing protein. (251 aa)
PLA2G4APhospholipase A2. (749 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (840 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
FAF1Fas associated factor 1. (650 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (762 aa)
GLUD1Glutamate dehydrogenase 1; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
RNF31Uncharacterized protein. (1072 aa)
IRF9Interferon regulatory factor 9. (392 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IFNB1Interferon beta 1. (187 aa)
G3RM71_GORGOHistone H2A; Belongs to the histone H2A family. (128 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
HIST1H2AKHistone H2A; Belongs to the histone H2A family. (130 aa)
CHMP2BCharged multivesicular body protein 2B. (228 aa)
G3RQE0_GORGOHistone H2A; Belongs to the histone H2A family. (129 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (289 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SQSTM1Sequestosome 1. (440 aa)
CHMP4B-2Uncharacterized protein. (201 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
SHARPINSHANK associated RH domain interactor. (387 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
PLA2G4FPhospholipase A2. (849 aa)
G3S148_GORGOUncharacterized protein. (157 aa)
IFNA2Interferon alpha 2. (170 aa)
G3S4Z2_GORGOUncharacterized protein. (119 aa)
G3S4Z9_GORGOHistone H2A; Belongs to the histone H2A family. (130 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (729 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1822 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FASFas cell surface death receptor. (340 aa)
HMGB1Uncharacterized protein. (215 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
G3SHJ3_GORGOHistone H2A; Belongs to the histone H2A family. (130 aa)
GLULGlutamine synthetase. (373 aa)
ENSGGOP00000029461Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSGGOP00000029696Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (155 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ENSGGOP00000031121Uncharacterized protein. (361 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (644 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
MLKLUncharacterized protein. (178 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
G3RKB0_GORGOHistone H2A; Belongs to the histone H2A family. (130 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
ENSGGOP00000038183Histone H2A; Belongs to the histone H2A family. (128 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CHMP6Uncharacterized protein. (224 aa)
IL33Interleukin 33. (270 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
IFNA13Interferon alpha 13. (195 aa)
GLUD2Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (380 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IFNAR2Uncharacterized protein. (519 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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