STRINGSTRING
WWTR1 WWTR1 GDF7 GDF7 PPP2CA PPP2CA LATS1 LATS1 WNT10A WNT10A BMP6 BMP6 SNAI2 SNAI2 TGFB3 TGFB3 YWHAQ YWHAQ TEAD3 TEAD3 PPP2R2B PPP2R2B BMP5 BMP5 FRMD6 FRMD6 LIMD1 LIMD1 APC2 APC2 LLGL1 LLGL1 RASSF6 RASSF6 WNT6 WNT6 WNT2B WNT2B BMPR1A BMPR1A PARD6A PARD6A AXIN2 AXIN2 WNT8A WNT8A NKD2 NKD2 WNT9A WNT9A YWHAB YWHAB SMAD2 SMAD2 DLG1 DLG1 PARD3 PARD3 YAP1 YAP1 BIRC3 BIRC3 CDH1 CDH1 YWHAH YWHAH WNT3 WNT3 PPP2R1A PPP2R1A DLG4 DLG4 FZD2 FZD2 RASSF1 RASSF1 SERPINE1 SERPINE1 G3QW78_GORGO G3QW78_GORGO GSK3B GSK3B WNT5A WNT5A NKD1 NKD1 DLG5 DLG5 BIRC2 BIRC2 TCF7L1 TCF7L1 CCND2 CCND2 GLI2 GLI2 WNT2 WNT2 FRMD1 FRMD1 PARD6B PARD6B SMAD7 SMAD7 AMOT AMOT WNT10B WNT10B WNT1 WNT1 MPP5 MPP5 LATS2 LATS2 PPP2R2A PPP2R2A BMPR1B BMPR1B WNT7A WNT7A PRKCZ PRKCZ SMAD4 SMAD4 PPP2CB PPP2CB ACTG1 ACTG1 AJUBA AJUBA SAV1 SAV1 WNT8B WNT8B BMP4 BMP4 WNT11 WNT11 CCND3 CCND3 G3RHQ4_GORGO G3RHQ4_GORGO FZD6 FZD6 BMP8A BMP8A ID1 ID1 WNT16 WNT16 TGFBR2 TGFBR2 FZD3 FZD3 FGF1 FGF1 AFP AFP APC APC MYC MYC YWHAZ YWHAZ GDF6 GDF6 BTRC BTRC WWC1 WWC1 BMP2 BMP2 AXIN1 AXIN1 AMH AMH AREG AREG WTIP WTIP CTNNA1 CTNNA1 SMAD1 SMAD1 DVL2 DVL2 TGFB1 TGFB1 CRB1 CRB1 FZD4 FZD4 TP53BP2 TP53BP2 CTNNA2 CTNNA2 MOB1B MOB1B TCF7 TCF7 PARD6G PARD6G CCND1 CCND1 ENSGGOP00000033016 ENSGGOP00000033016 PPP1CC PPP1CC NF2 NF2 WNT7B WNT7B WNT9B WNT9B FZD5 FZD5 PPP1CB PPP1CB FZD10 FZD10 BMPR2 BMPR2 PATJ PATJ YWHAE YWHAE DLG2 DLG2 WNT5B WNT5B TCF7L2 TCF7L2 DLG3 DLG3 PPP2R2C PPP2R2C CTNNA3 CTNNA3 YWHAG YWHAG SMAD3 SMAD3 ENSGGOP00000045882 ENSGGOP00000045882 STK3 STK3 MOB1A MOB1A WNT4 WNT4 FZD1 FZD1 FZD9 FZD9 CTNNB1 CTNNB1 DVL3 DVL3 FZD7 FZD7 BBC3 BBC3 TGFBR1 TGFBR1 SCRIB SCRIB CCN2 CCN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WWTR1WW domain containing transcription regulator 1. (400 aa)
GDF7Growth differentiation factor 7. (447 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
BMP6Bone morphogenetic protein 6. (515 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
BMP5TGF_BETA_2 domain-containing protein. (133 aa)
FRMD6FERM domain containing 6. (614 aa)
LIMD1LIM domains containing 1. (676 aa)
APC2APC regulator of WNT signaling pathway 2. (2289 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1064 aa)
RASSF6Ras association domain family member 6. (337 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PARD6APar-6 family cell polarity regulator alpha. (342 aa)
AXIN2Axin 2. (843 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (451 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
PARD3Par-3 family cell polarity regulator. (1260 aa)
YAP1Uncharacterized protein. (326 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (745 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
RASSF1Ras association domain family member 1. (340 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
G3QW78_GORGOProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1877 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
GLI2GLI family zinc finger 2. (1537 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
FRMD1FERM domain containing 1. (549 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
SMAD7MH2 domain-containing protein. (211 aa)
AMOTAngiomotin. (1086 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (345 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ACTG1Actin gamma 1. (375 aa)
AJUBAAjuba LIM protein. (538 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
G3RHQ4_GORGOTumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
BMP8ABone morphogenetic protein 8a. (402 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
AFPAlpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. (622 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
GDF6Growth differentiation factor 6. (455 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
WWC1WW and C2 domain containing 1. (1119 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
AXIN1Axin 1. (867 aa)
AMHAnti-Mullerian hormone. (560 aa)
AREGEGF-like domain-containing protein. (274 aa)
WTIPUncharacterized protein. (279 aa)
CTNNA1Catenin alpha 1. (906 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (528 aa)
TP53BP2Tumor protein p53 binding protein 2. (1137 aa)
CTNNA2Catenin alpha 2. (953 aa)
MOB1BMOB kinase activator 1B. (221 aa)
TCF7HMG box domain-containing protein. (300 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
ENSGGOP00000033016Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (419 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (346 aa)
NF2Neurofibromin 2. (595 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
PATJPATJ crumbs cell polarity complex component. (1726 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
TCF7L2HMG box domain-containing protein. (296 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (863 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (534 aa)
CTNNA3Catenin alpha 3. (895 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (250 aa)
SMAD3Mothers against decapentaplegic homolog. (356 aa)
ENSGGOP00000045882Actin beta. (378 aa)
STK3Serine/threonine kinase 3. (519 aa)
MOB1AMOB kinase activator 1A. (223 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
CTNNB1Catenin beta 1. (781 aa)
DVL3Dishevelled segment polarity protein 3. (77 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
BBC3Uncharacterized protein. (101 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SCRIBScribble planar cell polarity protein. (1658 aa)
CCN2Cellular communication network factor 2. (348 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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