STRINGSTRING
G3QCS7_GORGO G3QCS7_GORGO ZYX ZYX CAV3 CAV3 ITGA5 ITGA5 COL4A4 COL4A4 BCL2 BCL2 PTEN PTEN ITGA2 ITGA2 PPP1R12C PPP1R12C PDGFD PDGFD COL9A2 COL9A2 VEGFD VEGFD THBS2 THBS2 COL4A3 COL4A3 PAK1 PAK1 ITGA7 ITGA7 MAP2K1 MAP2K1 MYL12B MYL12B FLNA FLNA COL2A1 COL2A1 ERBB2 ERBB2 MYLK4 MYLK4 MYL2 MYL2 MYL7 MYL7 IGF1 IGF1 ROCK2 ROCK2 PAK5 PAK5 SPP1 SPP1 MYL5 MYL5 EGF EGF BIRC3 BIRC3 ACTN4 ACTN4 COL1A2 COL1A2 GRB2 GRB2 CHAD CHAD G3QUY9_GORGO G3QUY9_GORGO LAMA3 LAMA3 FLT4 FLT4 IBSP IBSP PDGFRB PDGFRB GSK3B GSK3B TLN1 TLN1 AKT3 AKT3 ITGB3 ITGB3 FYN FYN BIRC2 BIRC2 LAMB3 LAMB3 PDGFC PDGFC XIAP XIAP ELK1 ELK1 FLT1 FLT1 THBS3 THBS3 PIK3CA PIK3CA ITGB6 ITGB6 CCND2 CCND2 ITGB4 ITGB4 ROCK1 ROCK1 PIK3CB PIK3CB VASP VASP TNC TNC COL9A1 COL9A1 SHC4 SHC4 RAC2 RAC2 PDGFRA PDGFRA PRKCB PRKCB MYLK3 MYLK3 COL4A5 COL4A5 VTN VTN PAK6 PAK6 MYLK2 MYLK2 VEGFB VEGFB VAV1 VAV1 SHC3 SHC3 COL4A1 COL4A1 COL4A2 COL4A2 KDR KDR RHOA RHOA IGF1R IGF1R ITGA2B ITGA2B ITGA9 ITGA9 COL1A1 COL1A1 TNN TNN SHC1 SHC1 ITGA3 ITGA3 ACTG1 ACTG1 LAMC2 LAMC2 PARVA PARVA PGF PGF LAMB2 LAMB2 LAMA4 LAMA4 FN1 FN1 CAV2 CAV2 DOCK1 DOCK1 CCND3 CCND3 ITGA10 ITGA10 PDGFB PDGFB PRKCA PRKCA TNR TNR LAMA1 LAMA1 PARVG PARVG MYLK MYLK LAMB4 LAMB4 LAMC3 LAMC3 ITGA1 ITGA1 MYL9 MYL9 SRC SRC PIK3R3 PIK3R3 RAP1B RAP1B FLNB FLNB FLNC FLNC PTK2 PTK2 MAPK3 MAPK3 CAV1 CAV1 ITGA4 ITGA4 SOS1 SOS1 MAPK9 MAPK9 ITGB5 ITGB5 LAMC1 LAMC1 PDPK1 PDPK1 BRAF BRAF PIP5K1B PIP5K1B THBS4 THBS4 ARHGAP5 ARHGAP5 VAV2 VAV2 COL4A6 COL4A6 G3SFU6_GORGO G3SFU6_GORGO RAF1 RAF1 ITGB7 ITGB7 PAK2 PAK2 PIP5K1C PIP5K1C CCND1 CCND1 AKT2 AKT2 ITGA8 ITGA8 LAMB1 LAMB1 ITGB1 ITGB1 PARVB PARVB PRKCG PRKCG PPP1CC PPP1CC ENSGGOP00000036930 ENSGGOP00000036930 ENSGGOP00000037478 ENSGGOP00000037478 HGF HGF PPP1CB PPP1CB PDGFA PDGFA CRKL CRKL HRAS HRAS ILK ILK BAD BAD MAPK1 MAPK1 RELN RELN EGFR EGFR RASGRF1 RASGRF1 MET MET ITGA11 ITGA11 ITGAV ITGAV ITGA6 ITGA6 CDC42 CDC42 ARHGAP35 ARHGAP35 ENSGGOP00000045882 ENSGGOP00000045882 VAV3 VAV3 SOS2 SOS2 CTNNB1 CTNNB1 MAPK8 MAPK8 SHC2 SHC2 THBS1 THBS1 PIK3R1 PIK3R1 ACTN1 ACTN1 VEGFC VEGFC MAPK10 MAPK10 BCAR1 BCAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3QCS7_GORGOCollagen type VI alpha 6 chain. (2231 aa)
ZYXZyxin. (576 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (707 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
COL9A2Collagen type IX alpha 2 chain. (664 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
THBS2Thrombospondin 2. (1172 aa)
COL4A3Collagen type IV alpha 3 chain. (1578 aa)
PAK1Non-specific serine/threonine protein kinase. (554 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MYL12BMyosin light chain 12B. (172 aa)
FLNAFilamin A. (2647 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
MYL2Myosin light chain 2. (166 aa)
MYL7Myosin light chain 7. (175 aa)
IGF1IlGF domain-containing protein. (196 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. (460 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
MYL5Myosin light chain 5. (173 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1183 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
ACTN4Actinin alpha 4. (931 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CHADChondroadherin. (359 aa)
G3QUY9_GORGOCollagen type VI alpha 5 chain. (2623 aa)
LAMA3Laminin subunit alpha 3. (3152 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1319 aa)
IBSPIntegrin binding sialoprotein. (317 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
TLN1FERM domain-containing protein. (261 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (837 aa)
FYNTyrosine-protein kinase. (537 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
XIAPUncharacterized protein. (371 aa)
ELK1ETS transcription factor ELK1. (452 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1302 aa)
THBS3Thrombospondin 3. (956 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
ITGB4Integrin beta. (1805 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
TNCTenascin C. (2201 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
SHC4SHC adaptor protein 4. (630 aa)
RAC2Rac family small GTPase 2. (192 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
VTNVitronectin. (478 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
VAV1Vav guanine nucleotide exchange factor 1. (788 aa)
SHC3SHC adaptor protein 3. (598 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RHOAUncharacterized protein. (179 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
TNNTenascin N. (1299 aa)
SHC1SHC adaptor protein 1. (584 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
ACTG1Actin gamma 1. (375 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
PARVAParvin alpha. (412 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
FN1Fibronectin 1. (2477 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
TNRTenascin R. (1358 aa)
LAMA1Laminin subunit alpha 1. (3076 aa)
PARVGParvin gamma. (331 aa)
MYLKMyosin light chain kinase. (1914 aa)
LAMB4Laminin subunit beta 4. (1761 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
MYL9Myosin light chain 9. (172 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R3Uncharacterized protein. (507 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
FLNBFilamin B. (2633 aa)
FLNCFilamin C. (2725 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (796 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
PDPK1Protein kinase domain-containing protein. (347 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
THBS4Thrombospondin 4. (961 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
G3SFU6_GORGOMyosin light chain 12A. (177 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (707 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
LAMB1Laminin subunit beta 1. (1791 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PARVBParvin beta. (397 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (346 aa)
ENSGGOP00000036930Uncharacterized protein. (544 aa)
ENSGGOP00000037478PIPK domain-containing protein. (527 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (733 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (234 aa)
CRKLUncharacterized protein. (201 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ILKIntegrin linked kinase. (535 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELNReelin. (3455 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1273 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1409 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1189 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1002 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
CDC42Cell division cycle 42. (191 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
ENSGGOP00000045882Actin beta. (378 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
CTNNB1Catenin beta 1. (781 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SHC2Uncharacterized protein. (518 aa)
THBS1Thrombospondin 1. (1173 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
ACTN1Actinin alpha 1. (914 aa)
VEGFCPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (230 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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