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| | CARD8 | Caspase recruitment domain family member 8. (522 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | CTSB | Cathepsin B; Belongs to the peptidase C1 family. (339 aa) |
| | GPRC6A | G protein-coupled receptor class C group 6 member A. (928 aa) |
| | TRIP6 | Thyroid hormone receptor interactor 6. (476 aa) |
| | GBP5 | Guanylate binding protein 5. (586 aa) |
| | GBP2 | Guanylate binding protein 2. (591 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (284 aa) |
| | CARD16 | Caspase recruitment domain family member 16. (197 aa) |
| | TANK | TRAF family member associated NFKB activator. (425 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1972 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | CARD18 | Caspase recruitment domain family member 18. (90 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | CARD6 | Caspase recruitment domain family member 6. (1037 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | CXCL1 | C-X-C motif chemokine. (107 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | DEFA1B | DEFENSIN domain-containing protein. (94 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1028 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2706 aa) |
| | PANX-2 | Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa) |
| | ANTXR1 | Anthrax toxin receptor; Belongs to the ATR family. (564 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | TYK2 | Tyrosine-protein kinase. (1188 aa) |
| | IFI16 | Interferon gamma inducible protein 16. (785 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | GBP7 | Guanylate binding protein 7. (638 aa) |
| | G3QXY3_GORGO | Cytochrome b-245 beta chain. (570 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1087 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (687 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | XIAP | Uncharacterized protein. (371 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1065 aa) |
| | HSP90AB1 | Heat shock protein 90 alpha family class B member 1. (724 aa) |
| | RBCK1 | Uncharacterized protein. (204 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | MFN1 | Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | NLRP7 | NLR family pyrin domain containing 7. (1037 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (289 aa) |
| | DEFA4 | Defensin alpha 4. (97 aa) |
| | DEFA6 | Defensin alpha 6. (100 aa) |
| | NLRP1 | NLR family pyrin domain containing 1. (1471 aa) |
| | TXNIP | Thioredoxin interacting protein. (391 aa) |
| | G3R8R1_GORGO | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | CAMP | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | RHOA | Uncharacterized protein. (179 aa) |
| | GBP4 | Guanylate binding protein 4. (640 aa) |
| | GABARAP | GABA type A receptor-associated protein. (117 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (312 aa) |
| | GBP1 | Guanylate binding protein 1. (592 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (447 aa) |
| | PKN1 | Protein kinase N1. (948 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (781 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | RNF31 | Uncharacterized protein. (1072 aa) |
| | IRF9 | Interferon regulatory factor 9. (392 aa) |
| | DEFA5 | Defensin alpha 5. (94 aa) |
| | STING1 | Transmembrane protein 173. (379 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | ATG16L1 | Autophagy related 16 like 1. (624 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | GABARAPL1 | Uncharacterized protein. (117 aa) |
| | G3RR23_GORGO | Uncharacterized protein. (210 aa) |
| | IL6 | Interleukin 6. (234 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | RNASEL | Ribonuclease L. (741 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | CASR | Calcium sensing receptor. (1078 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (387 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | IFNA2 | Interferon alpha 2. (170 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | GBP3 | Guanylate binding protein 3. (597 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | CXCL3 | C-X-C motif chemokine. (107 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | G3S4Z2_GORGO | Uncharacterized protein. (119 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa) |
| | TRPM7 | Transient receptor potential cation channel subfamily M member 7. (1822 aa) |
| | G3SET6_GORGO | C-X-C motif chemokine. (107 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (414 aa) |
| | STAT1 | Signal transducer and activator of transcription. (777 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | ENSGGOP00000031121 | Uncharacterized protein. (361 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1204 aa) |
| | ENSGGOP00000032091 | Caspase 4; Belongs to the peptidase C14A family. (377 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (317 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (558 aa) |
| | ENSGGOP00000035522 | Interferon alpha 1. (198 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (308 aa) |
| | ERBIN | Erbb2 interacting protein. (1419 aa) |
| | DEFB103A | Beta-defensin 103A; Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria; Belongs to the beta-defensin family. (67 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa) |
| | TXN2 | Thioredoxin 2. (202 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | NAMPT | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa) |
| | NAIP | Uncharacterized protein. (198 aa) |
| | PKN2 | Protein kinase N2. (984 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | IFNA13 | Interferon alpha 13. (195 aa) |
| | NLRP6 | Uncharacterized protein. (912 aa) |
| | PYDC2 | Pyrin domain-containing protein. (97 aa) |
| | ENSGGOP00000046758 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | IFNAR2 | Uncharacterized protein. (519 aa) |
| | ENSGGOP00000051131 | Uncharacterized protein. (126 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | DHX33 | DEAH-box helicase 33. (707 aa) |
