STRINGSTRING
CSF2 CSF2 NCR2 NCR2 G3QGN8_GORGO G3QGN8_GORGO PRF1 PRF1 PAK1 PAK1 MAP2K1 MAP2K1 ULBP3 ULBP3 CD244 CD244 IFNG IFNG GRB2 GRB2 LCP2 LCP2 G3QVM2_GORGO G3QVM2_GORGO PLCG1 PLCG1 G3QY25_GORGO G3QY25_GORGO FYN FYN IFNGR1 IFNGR1 ARAF ARAF G3R0F2_GORGO G3R0F2_GORGO RAET1E RAET1E PIK3CA PIK3CA PIK3CB PIK3CB SYK SYK SHC4 SHC4 KLRD1 KLRD1 NCR1 NCR1 BID BID RAC2 RAC2 PRKCB PRKCB TNFRSF10B TNFRSF10B VAV1 VAV1 SHC3 SHC3 G3RB29_GORGO G3RB29_GORGO SHC1 SHC1 ICAM2 ICAM2 PTPN6 PTPN6 SH3BP2 SH3BP2 HCST HCST TYROBP TYROBP PTK2B PTK2B PRKCA PRKCA G3RKL3_GORGO G3RKL3_GORGO IFNB1 IFNB1 FCER1G FCER1G G3RQR5_GORGO G3RQR5_GORGO CD247 CD247 PIK3R3 PIK3R3 KLRC1 KLRC1 CASP3 CASP3 IFNA2 IFNA2 MAPK3 MAPK3 SOS1 SOS1 FASLG FASLG BRAF BRAF VAV2 VAV2 FAS FAS RAF1 RAF1 PPP3CB PPP3CB PLCG2 PLCG2 PTPN11 PTPN11 SH2D1A SH2D1A LCK LCK ENSGGOP00000032213 ENSGGOP00000032213 NRAS NRAS PPP3CA PPP3CA IFNAR1 IFNAR1 PRKCG PRKCG ENSGGOP00000035522 ENSGGOP00000035522 ICAM1 ICAM1 HRAS HRAS PPP3R1 PPP3R1 MAPK1 MAPK1 NFATC2 NFATC2 IFNA13 IFNA13 CD48 CD48 TNFRSF10A TNFRSF10A VAV3 VAV3 SOS2 SOS2 SHC2 SHC2 ITGAL ITGAL PIK3R1 PIK3R1 ULBP1 ULBP1 IFNAR2 IFNAR2 NFATC1 NFATC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSF2Colony stimulating factor 2. (144 aa)
NCR2Natural cytotoxicity triggering receptor 2. (276 aa)
G3QGN8_GORGOTyrosine-protein kinase. (599 aa)
PRF1Perforin 1. (555 aa)
PAK1Non-specific serine/threonine protein kinase. (554 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ULBP3UL16 binding protein 3. (244 aa)
CD244CD244 molecule. (365 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
G3QVM2_GORGOKiller cell lectin like receptor K1. (216 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
G3QY25_GORGOMHC_I-like_Ag-recog domain-containing protein. (246 aa)
FYNTyrosine-protein kinase. (537 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
G3R0F2_GORGOMitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RAET1EMHC_I-like_Ag-recog domain-containing protein. (263 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
SYKTyrosine-protein kinase. (635 aa)
SHC4SHC adaptor protein 4. (630 aa)
KLRD1Killer cell lectin like receptor D1. (179 aa)
NCR1Natural cytotoxicity triggering receptor 1. (304 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
RAC2Rac family small GTPase 2. (192 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
VAV1Vav guanine nucleotide exchange factor 1. (788 aa)
SHC3SHC adaptor protein 3. (598 aa)
G3RB29_GORGOGranzyme B; Belongs to the peptidase S1 family. (247 aa)
SHC1SHC adaptor protein 1. (584 aa)
ICAM2Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). (275 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SH3BP2SH3 domain binding protein 2. (619 aa)
HCSTHematopoietic cell signal transducer. (93 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
G3RKL3_GORGOMHC_I-like_Ag-recog domain-containing protein. (393 aa)
IFNB1Interferon beta 1. (187 aa)
FCER1GUncharacterized protein. (112 aa)
G3RQR5_GORGOIg-like domain-containing protein. (117 aa)
CD247CD247 molecule. (164 aa)
PIK3R3Uncharacterized protein. (507 aa)
KLRC1Killer cell lectin like receptor C1. (233 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IFNA2Interferon alpha 2. (170 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
FASFas cell surface death receptor. (340 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
LCKTyrosine-protein kinase. (524 aa)
ENSGGOP00000032213Ig-like domain-containing protein. (211 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (532 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PPP3R1Uncharacterized protein. (189 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
IFNA13Interferon alpha 13. (195 aa)
CD48CD48 molecule. (254 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
SHC2Uncharacterized protein. (518 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1181 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
ULBP1UL16 binding protein 1. (243 aa)
IFNAR2Uncharacterized protein. (519 aa)
NFATC1Nuclear factor of activated T cells 1. (948 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.