STRINGSTRING
FOS FOS CX3CL1 CX3CL1 MAP2K3 MAP2K3 BAG4 BAG4 CSF2 CSF2 TRAF1 TRAF1 VEGFD VEGFD VCAM1 VCAM1 TNFAIP3 TNFAIP3 CXCL1 CXCL1 MAP2K1 MAP2K1 MAPK13 MAPK13 CREB3L2 CREB3L2 RPS6KA5 RPS6KA5 TRAF3 TRAF3 MAP3K14 MAP3K14 RIPK3 RIPK3 IKBKG IKBKG MAP3K8 MAP3K8 CREB3L4 CREB3L4 BIRC3 BIRC3 G3QT71_GORGO G3QT71_GORGO IL1B IL1B IKBKB IKBKB ITCH ITCH CREB3 CREB3 AKT3 AKT3 TNFRSF1B TNFRSF1B TAB1 TAB1 BIRC2 BIRC2 CHUK CHUK PIK3CA PIK3CA NFKBIA NFKBIA PIK3CB PIK3CB CXCL6 CXCL6 ATF4 ATF4 MMP3 MMP3 CXCL10 CXCL10 NOD2 NOD2 CFLAR CFLAR TRADD TRADD CASP10 CASP10 RIPK1 RIPK1 TRAF5 TRAF5 IL18R1 IL18R1 EDN1 EDN1 MMP9 MMP9 IRF1 IRF1 MAPK12 MAPK12 CREB3L1 CREB3L1 CCL2 CCL2 CSF1 CSF1 TAB2 TAB2 IFNB1 IFNB1 PTGS2 PTGS2 PGAM5 PGAM5 IL6 IL6 NFKB1 NFKB1 TAB3 TAB3 PIK3R3 PIK3R3 FADD FADD MAP3K7 MAP3K7 JAG1 JAG1 CASP3 CASP3 MAPK3 MAPK3 CCL20 CCL20 MAP3K5 MAP3K5 CXCL3 CXCL3 MAPK11 MAPK11 MAPK9 MAPK9 MAP2K6 MAP2K6 G3SET6_GORGO G3SET6_GORGO TNFRSF1A TNFRSF1A FAS FAS RELA RELA LIF LIF CXCL5 CXCL5 DAB2IP DAB2IP ATF2 ATF2 ENSGGOP00000032596 ENSGGOP00000032596 AKT2 AKT2 SOCS3 SOCS3 MLKL MLKL ENSGGOP00000034747 ENSGGOP00000034747 ICAM1 ICAM1 ATF6B ATF6B ENSGGOP00000040207 ENSGGOP00000040207 MAPK1 MAPK1 IL15 IL15 RPS6KA4 RPS6KA4 MAP2K7 MAP2K7 CEBPB CEBPB CASP7 CASP7 JUNB JUNB MMP14 MMP14 MAPK8 MAPK8 SELE SELE PIK3R1 PIK3R1 VEGFC VEGFC MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
CSF2Colony stimulating factor 2. (144 aa)
TRAF1TNF receptor-associated factor. (416 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CXCL1C-X-C motif chemokine. (107 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
G3QT71_GORGOLymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
ITCHE3 ubiquitin-protein ligase. (903 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TNFRSF1BTNF receptor superfamily member 1B. (461 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
CXCL6C-X-C motif chemokine. (114 aa)
ATF4Activating transcription factor 4. (351 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
CXCL10C-X-C motif chemokine. (98 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
TRADDDeath domain-containing protein. (251 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
EDN1Endothelin 1. (212 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
IRF1Interferon regulatory factor. (325 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
CCL2C-C motif chemokine. (99 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNB1Interferon beta 1. (187 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (289 aa)
IL6Interleukin 6. (234 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
PIK3R3Uncharacterized protein. (507 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
CCL20C-C motif chemokine. (96 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
CXCL3C-X-C motif chemokine. (107 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
G3SET6_GORGOC-X-C motif chemokine. (107 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FASFas cell surface death receptor. (340 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CXCL5C-X-C motif chemokine. (114 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
MLKLUncharacterized protein. (178 aa)
ENSGGOP00000034747Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (532 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
ENSGGOP00000040207Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (511 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SELESelectin E. (612 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
VEGFCPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (230 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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