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ADCY9 ADCY9 PLCB2 PLCB2 GPX3 GPX3 ADCY6 ADCY6 ATP1B1 ATP1B1 ATP1B2 ATP1B2 GNAS GNAS G3QL18_GORGO G3QL18_GORGO ADCY3 ADCY3 CREB3L2 CREB3L2 TPO TPO ADCY4 ADCY4 ITPR1 ITPR1 SLC5A5 SLC5A5 CREB3L4 CREB3L4 TG TG GPX2 GPX2 G3QVI2_GORGO G3QVI2_GORGO CREB3 CREB3 TTF1 TTF1 CANX CANX ASGR1 ASGR1 ATF4 ATF4 TSHB TSHB PRKCB PRKCB ADCY2 ADCY2 DUOX2 DUOX2 DUOXA2 DUOXA2 PLCB3 PLCB3 DUOX1 DUOX1 GPX8 GPX8 GPX1 GPX1 ATP1A4 ATP1A4 ASGR2 ASGR2 GPX7 GPX7 CREB3L1 CREB3L1 TTF2 TTF2 PRKCA PRKCA LRP2 LRP2 TSHR TSHR ATP1B3 ATP1B3 ATP1B4 ATP1B4 SERPINA7 SERPINA7 PDIA4 PDIA4 ADCY5 ADCY5 ATP1A2 ATP1A2 HSPA5 HSPA5 ALB ALB HSP90B1 HSP90B1 ITPR3 ITPR3 PRKACB PRKACB SLC26A4 SLC26A4 ADCY7 ADCY7 PAX8 PAX8 CGA CGA ATF2 ATF2 ENSGGOP00000032065 ENSGGOP00000032065 PLCB4 PLCB4 ENSGGOP00000034747 ENSGGOP00000034747 PRKCG PRKCG ATP1A1 ATP1A1 ATF6B ATF6B ITPR2 ITPR2 PLCB1 PLCB1 ENSGGOP00000043747 ENSGGOP00000043747 ATP1A3 ATP1A3 IYD IYD ADCY8 ADCY8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (247 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
GNASGNAS complex locus. (985 aa)
G3QL18_GORGOUncharacterized protein. (453 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
TPOThyroid peroxidase. (933 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2706 aa)
SLC5A5Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (643 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
TGThyroglobulin. (2755 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (150 aa)
G3QVI2_GORGOGlutathione peroxidase; Belongs to the glutathione peroxidase family. (230 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
TTF1Transcription termination factor 1. (913 aa)
CANXCalnexin. (592 aa)
ASGR1Asialoglycoprotein receptor 1. (291 aa)
ATF4Activating transcription factor 4. (351 aa)
TSHBThyroid stimulating hormone subunit beta. (138 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1021 aa)
DUOX2Dual oxidase 2. (1548 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
DUOX1Dual oxidase 1. (1551 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
ASGR2Asialoglycoprotein receptor 2. (287 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (187 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
TTF2Transcription termination factor 2. (1162 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
LRP2LDL receptor related protein 2. (4653 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
SERPINA7Serpin family A member 7; Belongs to the serpin family. (415 aa)
PDIA4Protein disulfide-isomerase A4. (645 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1257 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
ALBAlbumin. (609 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (780 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1083 aa)
PAX8Paired domain-containing protein. (457 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (147 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSGGOP00000032065Uncharacterized protein. (245 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1204 aa)
ENSGGOP00000034747Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1035 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ENSGGOP00000043747Uncharacterized protein. (157 aa)
ATP1A3Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1204 aa)
IYDIodotyrosine deiodinase. (293 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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