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| | DYNC1H1 | Dynein cytoplasmic 1 heavy chain 1. (4646 aa) |
| | DYNC1I1 | Dynein cytoplasmic 1 intermediate chain 1. (645 aa) |
| | VPS39 | VPS39 subunit of HOPS complex. (886 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | FBXO22 | F-box protein 22. (403 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | VPS18 | VPS18 core subunit of CORVET and HOPS complexes. (973 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (554 aa) |
| | G3QL18_GORGO | Uncharacterized protein. (453 aa) |
| | SNX9 | Sorting nexin. (588 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | EXOC4 | Exocyst complex component 4. (974 aa) |
| | MYL12B | Myosin light chain 12B. (172 aa) |
| | ARPC5L | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa) |
| | FLNA | Filamin A. (2647 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | KPNA4 | Importin subunit alpha; Functions in nuclear protein import. (497 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1028 aa) |
| | MYL2 | Myosin light chain 2. (166 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | MYL7 | Myosin light chain 7. (175 aa) |
| | ROCK2 | Uncharacterized protein; Belongs to the protein kinase superfamily. (460 aa) |
| | DYNC1LI2 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (456 aa) |
| | VPS33A | VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. (596 aa) |
| | EXOC2 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (908 aa) |
| | RAB7A | RAB7A, member RAS oncogene family. (207 aa) |
| | MYL5 | Myosin light chain 5. (173 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | VPS41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (829 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ARPC5 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa) |
| | RHOJ | Ras homolog family member J. (214 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1127 aa) |
| | ARPC2 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (587 aa) |
| | G3R0F2_GORGO | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | HSP90AB1 | Heat shock protein 90 alpha family class B member 1. (724 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | STX10 | Syntaxin 10; Belongs to the syntaxin family. (249 aa) |
| | RAB9B | RAB9B, member RAS oncogene family. (201 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase. (335 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa) |
| | PFN3 | Profilin; Belongs to the profilin family. (137 aa) |
| | ANXA2 | Annexin. (357 aa) |
| | KLC4 | Kinesin light chain 4. (637 aa) |
| | DYNLT1 | Dynein light chain Tctex-type 1. (118 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (217 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (440 aa) |
| | ARF1 | ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa) |
| | TRADD | Death domain-containing protein. (251 aa) |
| | WASF3 | WASP family member 3. (502 aa) |
| | DYNC2H1 | Dynein cytoplasmic 2 heavy chain 1. (4314 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | RHOA | Uncharacterized protein. (179 aa) |
| | ARPC1B | Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa) |
| | ACTG1 | Actin gamma 1. (375 aa) |
| | ELMO2 | Engulfment and cell motility 2. (720 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (312 aa) |
| | PLEKHM2 | Pleckstrin homology and RUN domain containing M2. (1015 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (447 aa) |
| | PKN1 | Protein kinase N1. (948 aa) |
| | G3RID2_GORGO | TIR domain-containing protein. (1033 aa) |
| | KLC3 | Kinesin light chain 3. (504 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | KPNA1 | Importin subunit alpha; Functions in nuclear protein import. (538 aa) |
| | SNX33 | Sorting nexin. (574 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (215 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (497 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ELMO1 | Engulfment and cell motility 1. (727 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | ACBD3 | Acyl-CoA binding domain containing 3. (463 aa) |
| | G3RPX2_GORGO | DUF4206 domain-containing protein. (131 aa) |
| | G3RQE7_GORGO | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | MYL9 | Myosin light chain 9. (172 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | PIK3C2A | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa) |
| | IL6 | Interleukin 6. (234 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | TIRAP | TIR domain containing adaptor protein. (221 aa) |
| | EXOC5 | Uncharacterized protein. (518 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | PFN4 | Profilin; Belongs to the profilin family. (129 aa) |
| | EXOC7 | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | GCC2 | GRIP and coiled-coil domain containing 2. (1671 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | FLNB | Filamin B. (2633 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | BRK1 | BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa) |
| | FLNC | Filamin C. (2725 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | G3S0Z1_GORGO | Dynein light chain. (91 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | CYTH1 | Cytohesin 1. (399 aa) |
| | CYFIP1 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa) |
| | DYNLL2 | Uncharacterized protein. (183 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | FHOD1 | Formin homology 2 domain containing 1. (1182 aa) |
| | WASL | WASP like actin nucleation promoting factor. (505 aa) |
| | PFN2 | Profilin; Belongs to the profilin family. (188 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | G3S4Z2_GORGO | Uncharacterized protein. (119 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa) |
| | DNM2 | Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa) |
| | PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | G3S8N6_GORGO | Gp_dh_C domain-containing protein. (175 aa) |
| | S100A10 | S_100 domain-containing protein; Belongs to the S-100 family. (204 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa) |
| | AHNAK | PDZ domain-containing protein. (5891 aa) |
| | RAB9A | RAB9A, member RAS oncogene family. (201 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | HSP90B1 | Heat shock protein 90 beta family member 1. (814 aa) |
| | CYFIP2 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa) |
| | CSE1L | Chromosome segregation 1 like. (971 aa) |
| | G3SFU6_GORGO | Myosin light chain 12A. (177 aa) |
| | DYNC2LI1 | Dynein cytoplasmic 2 light intermediate chain 1. (351 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (630 aa) |
| | CYTH4 | Cytohesin 4. (394 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | DYNLRB1 | Robl_LC7 domain-containing protein. (149 aa) |
| | SNX18 | PX domain-containing protein. (430 aa) |
| | RHOB | Ras homolog family member B. (196 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (871 aa) |
| | ENSGGOP00000031121 | Uncharacterized protein. (361 aa) |
| | ARPC3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa) |
| | TCF7 | HMG box domain-containing protein. (300 aa) |
| | DYNC1I2 | Dynein cytoplasmic 1 intermediate chain 2. (650 aa) |
| | ENSGGOP00000032091 | Caspase 4; Belongs to the peptidase C14A family. (377 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | MLKL | Uncharacterized protein. (178 aa) |
| | MYO6 | Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa) |
| | FYCO1 | FYVE and coiled-coil domain containing 1. (1498 aa) |
| | CYTH2 | Uncharacterized protein. (422 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | M6PR | Mannose-6-phosphate receptor, cation dependent. (277 aa) |
| | TXN2 | Thioredoxin 2. (202 aa) |
| | ENSGGOP00000040207 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa) |
| | NCKAP1 | NCK associated protein 1. (1134 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | DYNLL1 | Dynein light chain. (89 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | RRAS | RAS related. (218 aa) |
| | ARF6 | ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa) |
| | TCF7L2 | HMG box domain-containing protein. (296 aa) |
| | NAIP | Uncharacterized protein. (198 aa) |
| | PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1636 aa) |
| | PIK3C2G | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa) |
| | CDC42 | Cell division cycle 42. (191 aa) |
| | AHNAK2 | Uncharacterized protein. (793 aa) |
| | ARPC4 | Uncharacterized protein. (229 aa) |
| | KPNA3 | Importin subunit alpha; Functions in nuclear protein import. (506 aa) |
| | ENSGGOP00000044780 | RUN domain-containing protein. (99 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (388 aa) |
| | RAB7B | RAB7B, member RAS oncogene family. (174 aa) |
| | ENSGGOP00000045882 | Actin beta. (378 aa) |
| | DYNLRB2 | Dynein light chain roadblock-type 2. (125 aa) |
| | RHOG | Ras homolog family member G. (191 aa) |
| | DYNLT3 | Uncharacterized protein. (71 aa) |
| | ENSGGOP00000046510 | Uncharacterized protein; Belongs to the SKP1 family. (164 aa) |
| | ENSGGOP00000046758 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | CYTH3 | Cytohesin 3. (399 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (468 aa) |
| | RALA | Uncharacterized protein. (112 aa) |
| | KLC2 | Kinesin light chain 2. (622 aa) |
| | RAB5C | RAB5C, member RAS oncogene family. (249 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ENSGGOP00000049412 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | PFN1 | Profilin; Belongs to the profilin family. (165 aa) |
