STRINGSTRING
CALM3 CALM3 FOS FOS ITGA5 ITGA5 IL23A IL23A C5 C5 IL1A IL1A MYD88 MYD88 MAPK13 MAPK13 ITGAM ITGAM IL12B IL12B NLRP3 NLRP3 TRAF6 TRAF6 IL1B IL1B IL12A IL12A GNAI1 GNAI1 CXCL6 CXCL6 C1QC C1QC C1QB C1QB CD14 CD14 C4BPB C4BPB C4BPA C4BPA RHOA RHOA IRF1 IRF1 IL10 IL10 MAPK12 MAPK12 G3RGQ1_GORGO G3RGQ1_GORGO LY96 LY96 SERPING1 SERPING1 PYCARD PYCARD NOS2 NOS2 IRAK1 IRAK1 IL6 IL6 NFKB1 NFKB1 TIRAP TIRAP TLR4 TLR4 IRAK4 IRAK4 CASP3 CASP3 MAPK3 MAPK3 NOD1 NOD1 MAPK11 MAPK11 MAPK9 MAPK9 TICAM2 TICAM2 IRF8 IRF8 C3 C3 CXCL8 CXCL8 GNAI3 GNAI3 RELA RELA CXCL5 CXCL5 CFL1 CFL1 ITGB1 ITGB1 ENSGGOP00000035349 ENSGGOP00000035349 C1R C1R MAPK1 MAPK1 C1S C1S CALML3 CALML3 ENSGGOP00000044488 ENSGGOP00000044488 ENSGGOP00000044877 ENSGGOP00000044877 CASP7 CASP7 CFL2 CFL2 ENSGGOP00000046758 ENSGGOP00000046758 CALML4 CALML4 MAPK8 MAPK8 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
C5Complement C5. (1646 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
NLRP3NLR family pyrin domain containing 3. (1028 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CXCL6C-X-C motif chemokine. (114 aa)
C1QCComplement C1q C chain. (245 aa)
C1QBComplement C1q B chain. (253 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
C4BPBComplement component 4 binding protein beta. (252 aa)
C4BPAComplement component 4 binding protein alpha. (599 aa)
RHOAUncharacterized protein. (179 aa)
IRF1Interferon regulatory factor. (325 aa)
IL10Interleukin 10. (178 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
G3RGQ1_GORGOSurfactant protein A2. (248 aa)
LY96Lymphocyte antigen 96. (160 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (496 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IL6Interleukin 6. (234 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
IRF8Interferon regulatory factor 8. (426 aa)
C3Complement C3. (1663 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
GNAI3G protein subunit alpha i3. (354 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CXCL5C-X-C motif chemokine. (114 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (198 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSGGOP00000035349Uncharacterized protein. (591 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (719 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (780 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ENSGGOP00000044488Uncharacterized protein. (1750 aa)
ENSGGOP00000044877Uncharacterized protein; Belongs to the calmodulin family. (123 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
CALML4Uncharacterized protein. (196 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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