STRINGSTRING
CASP9 CASP9 NLRC4 NLRC4 TLR2 TLR2 VCP VCP CXCL1 CXCL1 MYD88 MYD88 ITGAM ITGAM IL12B IL12B IL1B IL1B IL12A IL12A NFKB2 NFKB2 HSPD1 HSPD1 NFKBIA NFKBIA RAB1B RAB1B CD14 CD14 ARF1 ARF1 EEF1A2 EEF1A2 CLK4 CLK4 BNIP3 BNIP3 IL18 IL18 PYCARD PYCARD CLK1 CLK1 G3RQE7_GORGO G3RQE7_GORGO IL6 IL6 NFKB1 NFKB1 SAR1B SAR1B TLR4 TLR4 HSPA8 HSPA8 EEF1G EEF1G CASP3 CASP3 CXCL3 CXCL3 EEF1A1 EEF1A1 SAR1A SAR1A G3S9G1_GORGO G3S9G1_GORGO C3 C3 CXCL8 CXCL8 G3SET6_GORGO G3SET6_GORGO RELA RELA CYCS CYCS HBS1L HBS1L APAF1 APAF1 RAB1A RAB1A ENSGGOP00000041396 ENSGGOP00000041396 NAIP NAIP CASP7 CASP7 ENSGGOP00000046758 ENSGGOP00000046758 ENSGGOP00000049412 ENSGGOP00000049412 ENSGGOP00000050647 ENSGGOP00000050647
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
CXCL1C-X-C motif chemokine. (107 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NFKB2Nuclear factor kappa B subunit 2. (902 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
RAB1BUncharacterized protein. (216 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (464 aa)
CLK4CDC like kinase 4; Belongs to the protein kinase superfamily. (418 aa)
BNIP3Uncharacterized protein. (194 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PYCARDPYD and CARD domain containing. (195 aa)
CLK1CDC like kinase 1. (543 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IL6Interleukin 6. (234 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
SAR1BUncharacterized protein. (130 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
EEF1GUncharacterized protein. (437 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CXCL3C-X-C motif chemokine. (107 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
G3S9G1_GORGOHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
C3Complement C3. (1663 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
G3SET6_GORGOC-X-C motif chemokine. (107 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
HBS1LTr-type G domain-containing protein. (530 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
RAB1ARAB1A, member RAS oncogene family. (205 aa)
ENSGGOP00000041396Uncharacterized protein. (189 aa)
NAIPUncharacterized protein. (198 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (388 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
ENSGGOP00000050647Uncharacterized protein; Belongs to the synaptobrevin family. (214 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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