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MAP2K3 MAP2K3 BCL2 BCL2 TGFB3 TGFB3 CASP9 CASP9 NFKBIB NFKBIB PIK3R5 PIK3R5 TLR2 TLR2 MYD88 MYD88 MAPK13 MAPK13 IL12B IL12B IKBKG IKBKG BIRC3 BIRC3 TRAF6 TRAF6 TYK2 TYK2 IFNG IFNG LAMA3 LAMA3 IKBKB IKBKB IL12A IL12A BIRC8 BIRC8 AKT3 AKT3 TAB1 TAB1 GNAI1 GNAI1 BIRC2 BIRC2 BIRC7 BIRC7 LAMB3 LAMB3 IFNGR1 IFNGR1 XIAP XIAP CHUK CHUK NFKBIA NFKBIA G3R317_GORGO G3R317_GORGO G3R516_GORGO G3R516_GORGO G3R5S5_GORGO G3R5S5_GORGO IL10RB IL10RB ALOX5 ALOX5 G3QFY0_GORGO G3QFY0_GORGO G3RCR2_GORGO G3RCR2_GORGO CIITA CIITA IL10 IL10 MAPK12 MAPK12 LAMC2 LAMC2 SOCS1 SOCS1 LAMB2 LAMB2 LAMA4 LAMA4 LY96 LY96 LAMA1 LAMA1 JAK1 JAK1 TAB2 TAB2 LAMB4 LAMB4 LAMC3 LAMC3 G3RPG3_GORGO G3RPG3_GORGO G3RQE7_GORGO G3RQE7_GORGO MHC-DMB MHC-DMB NOS2 NOS2 IRAK1 IRAK1 IRGM IRGM NFKB1 NFKB1 STAT3 STAT3 MAP3K7 MAP3K7 TLR4 TLR4 BCL2L1 BCL2L1 HSPA8 HSPA8 IRAK4 IRAK4 IL10RA IL10RA CASP3 CASP3 G3S117_GORGO G3S117_GORGO MAPK3 MAPK3 MAPK11 MAPK11 MAPK9 MAPK9 LAMC1 LAMC1 PIK3CG PIK3CG CD40 CD40 G3S8P9_GORGO G3S8P9_GORGO MAP2K6 MAP2K6 G3S9G1_GORGO G3S9G1_GORGO PDPK1 PDPK1 GNAI3 GNAI3 TGFB1 TGFB1 STAT1 STAT1 TNFRSF1A TNFRSF1A RELA RELA G3SJ91_GORGO G3SJ91_GORGO CYCS CYCS ENSGGOP00000032596 ENSGGOP00000032596 AKT2 AKT2 LAMB1 LAMB1 ITGB1 ITGB1 CD40LG CD40LG LDLR LDLR BAD BAD MAPK1 MAPK1 ENSGGOP00000042764 ENSGGOP00000042764 ITGA6 ITGA6 MAPK8 MAPK8 ENSGGOP00000049412 ENSGGOP00000049412 MAPK10 MAPK10 CCR5 CCR5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LAMA3Laminin subunit alpha 3. (3152 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
BIRC8Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
GNAI1G protein subunit alpha i1. (354 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
XIAPUncharacterized protein. (371 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
G3R317_GORGOMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
G3R516_GORGOMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
G3R5S5_GORGOMajor histocompatibility complex, class II, DO beta. (273 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
ALOX5Arachidonate 5-lipoxygenase. (678 aa)
G3QFY0_GORGOMajor histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
G3RCR2_GORGOMajor histocompatibility complex, class II, DP beta 1. (258 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
IL10Interleukin 10. (178 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
LY96Lymphocyte antigen 96. (160 aa)
LAMA1Laminin subunit alpha 1. (3076 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LAMB4Laminin subunit beta 4. (1761 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
G3RPG3_GORGOMajor histocompatibility complex, class II, DQ beta 1. (261 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MHC-DMBIg-like domain-containing protein. (263 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IRGMImmunity related GTPase M. (181 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
BCL2L1BCL2 like 1. (233 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
G3S117_GORGOMajor histocompatibility complex, class II, DR beta 5. (266 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CD40CD40 molecule. (277 aa)
G3S8P9_GORGOMajor histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
G3S9G1_GORGOHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
PDPK1Protein kinase domain-containing protein. (347 aa)
GNAI3G protein subunit alpha i3. (354 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
G3SJ91_GORGOMajor histocompatibility complex, class II, DQ beta 2. (264 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LAMB1Laminin subunit beta 1. (1791 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
LDLRLow density lipoprotein receptor. (859 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSGGOP00000042764Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (206 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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