STRINGSTRING
CALM3 CALM3 BCL2 BCL2 G3QGD7_GORGO G3QGD7_GORGO TGFB3 TGFB3 IL23A IL23A MRC2 MRC2 CASP9 CASP9 LSP1 LSP1 LAMP1 LAMP1 TLR2 TLR2 IL1A IL1A MYD88 MYD88 FCGR2A FCGR2A MAPK13 MAPK13 ITGAM ITGAM IL12B IL12B TCIRG1 TCIRG1 EEA1 EEA1 RAB7A RAB7A TRAF6 TRAF6 CREBBP CREBBP IFNG IFNG IL1B IL1B IL12A IL12A G3QX51_GORGO G3QX51_GORGO AKT3 AKT3 EP300 EP300 HSPD1 HSPD1 PLA2R1 PLA2R1 IFNGR1 IFNGR1 ATP6V0A4 ATP6V0A4 NFYB NFYB ATP6V0A2 ATP6V0A2 G3R317_GORGO G3R317_GORGO BAX BAX CD14 CD14 SYK SYK BID BID G3R516_GORGO G3R516_GORGO NOD2 NOD2 RIPK2 RIPK2 G3R5S5_GORGO G3R5S5_GORGO TRADD TRADD CLEC4E CLEC4E IL10RB IL10RB CASP10 CASP10 CAMP CAMP RFXANK RFXANK CORO1A CORO1A RHOA RHOA G3QFY0_GORGO G3QFY0_GORGO G3RCR2_GORGO G3RCR2_GORGO ATP6V0D2 ATP6V0D2 CIITA CIITA HSPA9 HSPA9 IL10 IL10 MAPK12 MAPK12 G3RID2_GORGO G3RID2_GORGO IL18 IL18 RAB5A RAB5A JAK1 JAK1 VDR VDR RFX5 RFX5 SPHK1 SPHK1 IFNB1 IFNB1 G3RPG3_GORGO G3RPG3_GORGO FCER1G FCER1G G3RQE7_GORGO G3RQE7_GORGO MHC-DMB MHC-DMB G3RQR5_GORGO G3RQR5_GORGO NOS2 NOS2 ATP6V0C ATP6V0C IRAK1 IRAK1 SRC SRC IL6 IL6 NFKB1 NFKB1 TIRAP TIRAP FADD FADD PLK3 PLK3 MALT1 MALT1 TLR4 TLR4 IRAK4 IRAK4 IL10RA IL10RA CASP3 CASP3 G3S117_GORGO G3S117_GORGO IFNA2 IFNA2 CLEC4M CLEC4M MAPK3 MAPK3 ITGAX ITGAX MAPK11 MAPK11 MAPK9 MAPK9 FCGR2B FCGR2B G3S8P9_GORGO G3S8P9_GORGO C3 C3 TGFB1 TGFB1 RFXAP RFXAP STAT1 STAT1 TNFRSF1A TNFRSF1A RAF1 RAF1 PPP3CB PPP3CB RELA RELA G3SJ91_GORGO G3SJ91_GORGO CYCS CYCS CAMK2A CAMK2A CD209 CD209 ENSGGOP00000032213 ENSGGOP00000032213 AKT2 AKT2 PPP3CA PPP3CA CAMK2B CAMK2B FCGR1A FCGR1A APAF1 APAF1 ENSGGOP00000035522 ENSGGOP00000035522 PIK3C3 PIK3C3 PPP3R1 PPP3R1 BAD BAD MAPK1 MAPK1 CALML3 CALML3 ATP6V1H ATP6V1H NFYA NFYA CEBPG CEBPG CEBPB CEBPB ENSGGOP00000044877 ENSGGOP00000044877 IFNA13 IFNA13 ARHGEF12 ARHGEF12 RAB5C RAB5C CALML4 CALML4 MAPK8 MAPK8 ENSGGOP00000049412 ENSGGOP00000049412 ATP6V0B ATP6V0B BCL10 BCL10 MAPK10 MAPK10
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
G3QGD7_GORGOCytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
MRC2Mannose receptor C type 2. (1479 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
LSP1Lymphocyte specific protein 1. (467 aa)
LAMP1Lysosomal associated membrane protein 1. (465 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
FCGR2AFc fragment of IgG receptor IIa. (317 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
EEA1Early endosome antigen 1. (1411 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
CREBBPCREB binding protein. (2436 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
G3QX51_GORGOLipopolysaccharide binding protein. (481 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EP300E1A binding protein p300. (2416 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa)
PLA2R1Phospholipase A2 receptor 1. (1474 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
NFYBNuclear transcription factor Y subunit beta. (169 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
G3R317_GORGOMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
SYKTyrosine-protein kinase. (635 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
G3R516_GORGOMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
G3R5S5_GORGOMajor histocompatibility complex, class II, DO beta. (273 aa)
TRADDDeath domain-containing protein. (251 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
CAMPCathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa)
RFXANKRegulatory factor X associated ankyrin containing protein. (259 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
RHOAUncharacterized protein. (179 aa)
G3QFY0_GORGOMajor histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
G3RCR2_GORGOMajor histocompatibility complex, class II, DP beta 1. (258 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
CIITAClass II major histocompatibility complex transactivator. (1131 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
IL10Interleukin 10. (178 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
G3RID2_GORGOTIR domain-containing protein. (1033 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
VDRVitamin D receptor. (477 aa)
RFX5Regulatory factor X5. (616 aa)
SPHK1Sphingosine kinase 1. (472 aa)
IFNB1Interferon beta 1. (187 aa)
G3RPG3_GORGOMajor histocompatibility complex, class II, DQ beta 1. (261 aa)
FCER1GUncharacterized protein. (112 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MHC-DMBIg-like domain-containing protein. (263 aa)
G3RQR5_GORGOIg-like domain-containing protein. (117 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
SRCTyrosine-protein kinase. (542 aa)
IL6Interleukin 6. (234 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
PLK3Serine/threonine-protein kinase PLK. (673 aa)
MALT1MALT1 paracaspase. (824 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
G3S117_GORGOMajor histocompatibility complex, class II, DR beta 5. (266 aa)
IFNA2Interferon alpha 2. (170 aa)
CLEC4MC-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (376 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1169 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FCGR2BUncharacterized protein. (310 aa)
G3S8P9_GORGOMajor histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa)
C3Complement C3. (1663 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RFXAPRegulatory factor X associated protein. (272 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
G3SJ91_GORGOMajor histocompatibility complex, class II, DQ beta 2. (264 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (268 aa)
ENSGGOP00000032213Ig-like domain-containing protein. (211 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (644 aa)
FCGR1AUncharacterized protein. (374 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
PPP3R1Uncharacterized protein. (189 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
ENSGGOP00000044877Uncharacterized protein; Belongs to the calmodulin family. (123 aa)
IFNA13Interferon alpha 13. (195 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1504 aa)
RAB5CRAB5C, member RAS oncogene family. (249 aa)
CALML4Uncharacterized protein. (196 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
BCL10CARD domain-containing protein. (316 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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