Your Input: | |
| | CALM3 | Calmodulin 1; Belongs to the calmodulin family. (149 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | G3QGD7_GORGO | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | IL23A | Interleukin 23 subunit alpha. (189 aa) |
| | MRC2 | Mannose receptor C type 2. (1479 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (446 aa) |
| | LSP1 | Lymphocyte specific protein 1. (467 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (465 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | FCGR2A | Fc fragment of IgG receptor IIa. (317 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | EEA1 | Early endosome antigen 1. (1411 aa) |
| | RAB7A | RAB7A, member RAS oncogene family. (207 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | CREBBP | CREB binding protein. (2436 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | G3QX51_GORGO | Lipopolysaccharide binding protein. (481 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | EP300 | E1A binding protein p300. (2416 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (609 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1474 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (489 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (169 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa) |
| | G3R317_GORGO | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (217 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa) |
| | G3R516_GORGO | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | G3R5S5_GORGO | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | TRADD | Death domain-containing protein. (251 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (219 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (325 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (523 aa) |
| | CAMP | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa) |
| | RFXANK | Regulatory factor X associated ankyrin containing protein. (259 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | RHOA | Uncharacterized protein. (179 aa) |
| | G3QFY0_GORGO | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | G3RCR2_GORGO | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1131 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | IL10 | Interleukin 10. (178 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (312 aa) |
| | G3RID2_GORGO | TIR domain-containing protein. (1033 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (215 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | VDR | Vitamin D receptor. (477 aa) |
| | RFX5 | Regulatory factor X5. (616 aa) |
| | SPHK1 | Sphingosine kinase 1. (472 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | G3RPG3_GORGO | Major histocompatibility complex, class II, DQ beta 1. (261 aa) |
| | FCER1G | Uncharacterized protein. (112 aa) |
| | G3RQE7_GORGO | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | MHC-DMB | Ig-like domain-containing protein. (263 aa) |
| | G3RQR5_GORGO | Ig-like domain-containing protein. (117 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | IL6 | Interleukin 6. (234 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | TIRAP | TIR domain containing adaptor protein. (221 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | MALT1 | MALT1 paracaspase. (824 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (578 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | G3S117_GORGO | Major histocompatibility complex, class II, DR beta 5. (266 aa) |
| | IFNA2 | Interferon alpha 2. (170 aa) |
| | CLEC4M | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (376 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | ITGAX | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1169 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | FCGR2B | Uncharacterized protein. (310 aa) |
| | G3S8P9_GORGO | Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa) |
| | C3 | Complement C3. (1663 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | RFXAP | Regulatory factor X associated protein. (272 aa) |
| | STAT1 | Signal transducer and activator of transcription. (777 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (630 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (524 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | G3SJ91_GORGO | Major histocompatibility complex, class II, DQ beta 2. (264 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | CD209 | CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (268 aa) |
| | ENSGGOP00000032213 | Ig-like domain-containing protein. (211 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (644 aa) |
| | FCGR1A | Uncharacterized protein. (374 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | ENSGGOP00000035522 | Interferon alpha 1. (198 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa) |
| | PPP3R1 | Uncharacterized protein. (189 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (347 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (150 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (345 aa) |
| | ENSGGOP00000044877 | Uncharacterized protein; Belongs to the calmodulin family. (123 aa) |
| | IFNA13 | Interferon alpha 13. (195 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1504 aa) |
| | RAB5C | RAB5C, member RAS oncogene family. (249 aa) |
| | CALML4 | Uncharacterized protein. (196 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ENSGGOP00000049412 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa) |
| | BCL10 | CARD domain-containing protein. (316 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
