STRINGSTRING
CLDN20 CLDN20 PPP2CA PPP2CA CLDN17 CLDN17 CDK4 CDK4 MX2 MX2 MX1 MX1 YWHAQ YWHAQ EIF2S1 EIF2S1 PPP2R2B PPP2R2B CASP9 CASP9 E2F1 E2F1 MAP2K1 MAP2K1 TRAF3 TRAF3 YWHAB YWHAB IKBKG IKBKG CLDN19 CLDN19 EGF EGF TRAF6 TRAF6 TYK2 TYK2 IFNG IFNG YWHAH YWHAH GRB2 GRB2 PPP2R1A PPP2R1A IKBKB IKBKB GSK3B GSK3B CD81 CD81 AKT3 AKT3 OAS3 OAS3 OAS2 OAS2 NR1H3 NR1H3 ARAF ARAF G3R0F2_GORGO G3R0F2_GORGO CHUK CHUK PIK3CA PIK3CA NFKBIA NFKBIA PIK3CB PIK3CB BAX BAX BID BID CXCL10 CXCL10 RSAD2 RSAD2 CFLAR CFLAR E2F3 E2F3 PPP2R2A PPP2R2A EIF2AK3 EIF2AK3 TRADD TRADD RIPK1 RIPK1 PPP2CB PPP2CB CLDN1 CLDN1 CLDN14 CLDN14 IRF9 IRF9 EIF2AK1 EIF2AK1 JAK1 JAK1 IFNB1 IFNB1 G3RQE7_GORGO G3RQE7_GORGO MYC MYC YWHAZ YWHAZ NFKB1 NFKB1 CDKN1A CDKN1A BAK1 BAK1 PIK3R3 PIK3R3 EIF2AK2 EIF2AK2 RNASEL RNASEL IKBKE IKBKE FADD FADD STAT3 STAT3 G3RZ65_GORGO G3RZ65_GORGO CASP3 CASP3 IFNA2 IFNA2 MAPK3 MAPK3 CLDN3 CLDN3 SOS1 SOS1 IFIT1B IFIT1B IFIT1 IFIT1 DDX58 DDX58 CLDN8 CLDN8 EIF2AK4 EIF2AK4 TBK1 TBK1 FASLG FASLG BRAF BRAF CLDN15 CLDN15 CLDN10 CLDN10 OAS1 OAS1 STAT1 STAT1 TNFRSF1A TNFRSF1A FAS FAS RAF1 RAF1 TLR3 TLR3 CLDN22 CLDN22 RELA RELA CLDN7 CLDN7 CYCS CYCS CLDN16 CLDN16 PIAS1 PIAS1 CLDN2 CLDN2 TP53 TP53 ENSGGOP00000032596 ENSGGOP00000032596 CCND1 CCND1 NRAS NRAS AKT2 AKT2 SOCS3 SOCS3 IFNAR1 IFNAR1 APAF1 APAF1 ENSGGOP00000035522 ENSGGOP00000035522 EIF3E EIF3E LDLR LDLR HRAS HRAS BAD BAD MAPK1 MAPK1 YWHAE YWHAE PPARA PPARA EGFR EGFR CLDN9 CLDN9 RXRA RXRA PSME3 PSME3 IRF7 IRF7 PPP2R2C PPP2R2C CLDN4 CLDN4 IFNA13 IFNA13 YWHAG YWHAG SCARB1 SCARB1 CLDN11 CLDN11 SOS2 SOS2 CTNNB1 CTNNB1 ENSGGOP00000049412 ENSGGOP00000049412 PIK3R1 PIK3R1 IFNAR2 IFNAR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (662 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
E2F1E2F transcription factor 1. (437 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1183 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CD81Tetraspanin. (260 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1087 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
G3R0F2_GORGOMitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
CXCL10C-X-C motif chemokine. (98 aa)
RSAD2Elp3 domain-containing protein. (361 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
E2F3E2F transcription factor 3. (408 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
TRADDDeath domain-containing protein. (251 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
IRF9Interferon regulatory factor 9. (392 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
IFNB1Interferon beta 1. (187 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3R3Uncharacterized protein. (507 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
RNASELRibonuclease L. (741 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
G3RZ65_GORGOClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IFNA2Interferon alpha 2. (170 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
IFIT1BInterferon induced protein with tetratricopeptide repeats 1B. (473 aa)
IFIT1Interferon induced protein with tetratricopeptide repeats 1. (478 aa)
DDX58DExD/H-box helicase 58. (925 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
TBK1TANK binding kinase 1. (729 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
OAS12'-5'-oligoadenylate synthetase 1. (414 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FASFas cell surface death receptor. (340 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (305 aa)
PIAS1Protein inhibitor of activated STAT 1. (653 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (457 aa)
LDLRLow density lipoprotein receptor. (859 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
RXRARetinoid X receptor alpha. (463 aa)
PSME3Proteasome activator subunit 3. (265 aa)
IRF7Interferon regulatory factor 7. (516 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (534 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
IFNA13Interferon alpha 13. (195 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (250 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
IFNAR2Uncharacterized protein. (519 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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