STRINGSTRING
FOS FOS MAP2K3 MAP2K3 BCL2 BCL2 STAT6 STAT6 TGFB3 TGFB3 YWHAQ YWHAQ PCNA PCNA VDAC3 VDAC3 CASP9 CASP9 CCNA2 CCNA2 EGR3 EGR3 TLR2 TLR2 E2F1 E2F1 MAP2K1 MAP2K1 MYD88 MYD88 MAPK13 MAPK13 CREB3L2 CREB3L2 TRAF3 TRAF3 YWHAB YWHAB IKBKG IKBKG EGR2 EGR2 CREB3L4 CREB3L4 TRAF6 TRAF6 TYK2 TYK2 CREBBP CREBBP GRB2 GRB2 IKBKB IKBKB CREB3 CREB3 AKT3 AKT3 TAB1 TAB1 EP300 EP300 CCNE1 CCNE1 ARAF ARAF ELK1 ELK1 NFATC4 NFATC4 G3R0F2_GORGO G3R0F2_GORGO CHUK CHUK PIK3CA PIK3CA NFKBIA NFKBIA PIK3CB PIK3CB ATF4 ATF4 BAX BAX BID BID PRKCB PRKCB E2F3 E2F3 G3R8R1_GORGO G3R8R1_GORGO CASP10 CASP10 HSPG2 HSPG2 MMP9 MMP9 SMAD4 SMAD4 MAPK12 MAPK12 MAP3K1 MAP3K1 CCNE2 CCNE2 CREB3L1 CREB3L1 PTK2B PTK2B IFIH1 IFIH1 PRKCA PRKCA JAK1 JAK1 TAB2 TAB2 TGFBR2 TGFBR2 IFNB1 IFNB1 G3RQE7_GORGO G3RQE7_GORGO IRAK1 IRAK1 SRC SRC IL6 IL6 MYC MYC YWHAZ YWHAZ NFKB1 NFKB1 CDKN1A CDKN1A TIRAP TIRAP PIK3R3 PIK3R3 IKBKE IKBKE G3RVS4_GORGO G3RVS4_GORGO FADD FADD STAT3 STAT3 MAP3K7 MAP3K7 TLR4 TLR4 IRAK4 IRAK4 CASP3 CASP3 IFNA2 IFNA2 MAPK3 MAPK3 SOS1 SOS1 MAPK11 MAPK11 MAPK9 MAPK9 TICAM2 TICAM2 DDX58 DDX58 TBK1 TBK1 MAP2K6 MAP2K6 FASLG FASLG CXCL8 CXCL8 BRAF BRAF CCNA1 CCNA1 TGFB1 TGFB1 STAT1 STAT1 FAS FAS RAF1 RAF1 TLR3 TLR3 RELA RELA DDX3X DDX3X CYCS CYCS TP53 TP53 ATF2 ATF2 ENSGGOP00000032596 ENSGGOP00000032596 NRAS NRAS AKT2 AKT2 IFNAR1 IFNAR1 ENSGGOP00000034747 ENSGGOP00000034747 PRKCG PRKCG APAF1 APAF1 ENSGGOP00000035522 ENSGGOP00000035522 ATF6B ATF6B HRAS HRAS BAD BAD ENSGGOP00000040207 ENSGGOP00000040207 MAPK1 MAPK1 MAP2K7 MAP2K7 STAT4 STAT4 NFATC2 NFATC2 IRF7 IRF7 IFNA13 IFNA13 SMAD3 SMAD3 DDB2 DDB2 DDB1 DDB1 SOS2 SOS2 MAPK8 MAPK8 ENSGGOP00000049412 ENSGGOP00000049412 PIK3R1 PIK3R1 TGFBR1 TGFBR1 MAPK10 MAPK10 NFATC1 NFATC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
EGR3Early growth response 3. (349 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
E2F1E2F transcription factor 1. (437 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
EGR2Early growth response 2. (476 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
CREBBPCREB binding protein. (2436 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
EP300E1A binding protein p300. (2416 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ELK1ETS transcription factor ELK1. (452 aa)
NFATC4Nuclear factor of activated T cells 4. (920 aa)
G3R0F2_GORGOMitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ATF4Activating transcription factor 4. (351 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
E2F3E2F transcription factor 3. (408 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
HSPG2Heparan sulfate proteoglycan 2. (4370 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1347 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
IFNB1Interferon beta 1. (187 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
SRCTyrosine-protein kinase. (542 aa)
IL6Interleukin 6. (234 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
PIK3R3Uncharacterized protein. (507 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IFNA2Interferon alpha 2. (170 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
DDX58DExD/H-box helicase 58. (925 aa)
TBK1TANK binding kinase 1. (729 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
FASFas cell surface death receptor. (340 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
ENSGGOP00000034747Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ENSGGOP00000040207Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
IRF7Interferon regulatory factor 7. (516 aa)
IFNA13Interferon alpha 13. (195 aa)
SMAD3Mothers against decapentaplegic homolog. (356 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
NFATC1Nuclear factor of activated T cells 1. (948 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (18%) [HD]