STRINGSTRING
CD46 CD46 FOS FOS EIF3H EIF3H BCL2 BCL2 CDK4 CDK4 MX2 MX2 MX1 MX1 EIF2S1 EIF2S1 CASP9 CASP9 IL2RB IL2RB NFKBIB NFKBIB TLR2 TLR2 TNFAIP3 TNFAIP3 IL1A IL1A MYD88 MYD88 TRAF3 TRAF3 IL12B IL12B IKBKG IKBKG TRAF6 TRAF6 TYK2 TYK2 IL1B IL1B CD3E CD3E IKBKB IKBKB IL12A IL12A GSK3B GSK3B AKT3 AKT3 OAS3 OAS3 OAS2 OAS2 CCNE1 CCNE1 CHUK CHUK PIK3CA PIK3CA NFKBIA NFKBIA CCND2 CCND2 RAB9B RAB9B PIK3CB PIK3CB BAX BAX BID BID EIF2AK3 EIF2AK3 TRADD TRADD CCNE2 CCNE2 CCND3 CCND3 G3RHQ4_GORGO G3RHQ4_GORGO G3RID2_GORGO G3RID2_GORGO IFIH1 IFIH1 IRF9 IRF9 EIF2AK1 EIF2AK1 JAK1 JAK1 TAB2 TAB2 IFNB1 IFNB1 G3RQE7_GORGO G3RQE7_GORGO IRAK1 IRAK1 IL6 IL6 NFKB1 NFKB1 BAK1 BAK1 PIK3R3 PIK3R3 EIF2AK2 EIF2AK2 IKBKE IKBKE SLAMF1 SLAMF1 G3RVS4_GORGO G3RVS4_GORGO FADD FADD STAT3 STAT3 TLR7 TLR7 MAP3K7 MAP3K7 TLR4 TLR4 BCL2L1 BCL2L1 HSPA8 HSPA8 IRAK4 IRAK4 CASP3 CASP3 IFNA2 IFNA2 CLEC4M CLEC4M IL2 IL2 IL2RA IL2RA MAPK9 MAPK9 DDX58 DDX58 FCGR2B FCGR2B EIF2AK4 EIF2AK4 TBK1 TBK1 G3S9G1_GORGO G3S9G1_GORGO FASLG FASLG RAB9A RAB9A ADAR ADAR RCHY1 RCHY1 MSN MSN OAS1 OAS1 STAT1 STAT1 CD3G CD3G FAS FAS RELA RELA CYCS CYCS TP53 TP53 CD28 CD28 CD209 CD209 CSNK2A1 CSNK2A1 ENSGGOP00000032596 ENSGGOP00000032596 CCND1 CCND1 AKT2 AKT2 IFNAR1 IFNAR1 CD3D CD3D APAF1 APAF1 ENSGGOP00000035522 ENSGGOP00000035522 BAD BAD IRF7 IRF7 IFNA13 IFNA13 MAPK8 MAPK8 ENSGGOP00000049412 ENSGGOP00000049412 CDKN1B CDKN1B PIK3R1 PIK3R1 BBC3 BBC3 CSNK2A2 CSNK2A2 IFNAR2 IFNAR2 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD46CD46 molecule. (399 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (366 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (662 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CD3ECD3e molecule. (207 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1087 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
TRADDDeath domain-containing protein. (251 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
G3RHQ4_GORGOTumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
G3RID2_GORGOTIR domain-containing protein. (1033 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
IRF9Interferon regulatory factor 9. (392 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNB1Interferon beta 1. (187 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IL6Interleukin 6. (234 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3R3Uncharacterized protein. (507 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
BCL2L1BCL2 like 1. (233 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IFNA2Interferon alpha 2. (170 aa)
CLEC4MC-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (376 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DDX58DExD/H-box helicase 58. (925 aa)
FCGR2BUncharacterized protein. (310 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
TBK1TANK binding kinase 1. (729 aa)
G3S9G1_GORGOHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
ADARAdenosine deaminase RNA specific. (1229 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
MSNMoesin. (577 aa)
OAS12'-5'-oligoadenylate synthetase 1. (414 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
CD3GCD3g molecule. (182 aa)
FASFas cell surface death receptor. (340 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
CD28CD28 molecule. (220 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (268 aa)
CSNK2A1Casein kinase 2 alpha 1; Belongs to the protein kinase superfamily. (391 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
CD3DCD3d molecule. (171 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
BADBCL2 associated agonist of cell death. (168 aa)
IRF7Interferon regulatory factor 7. (516 aa)
IFNA13Interferon alpha 13. (195 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
CDKN1BUncharacterized protein. (205 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
BBC3Uncharacterized protein. (101 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (334 aa)
IFNAR2Uncharacterized protein. (519 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (38%) [HD]