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| | CD46 | CD46 molecule. (399 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | EIF3H | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (366 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | MX2 | MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa) |
| | MX1 | MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (662 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (446 aa) |
| | IL2RB | Interleukin 2 receptor subunit beta. (551 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | TYK2 | Tyrosine-protein kinase. (1188 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | CD3E | CD3e molecule. (207 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1087 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (687 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | RAB9B | RAB9B, member RAS oncogene family. (201 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (217 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa) |
| | TRADD | Death domain-containing protein. (251 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | G3RHQ4_GORGO | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa) |
| | G3RID2_GORGO | TIR domain-containing protein. (1033 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1025 aa) |
| | IRF9 | Interferon regulatory factor 9. (392 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | G3RQE7_GORGO | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | IL6 | Interleukin 6. (234 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | SLAMF1 | Signaling lymphocytic activation molecule family member 1. (357 aa) |
| | G3RVS4_GORGO | Signal transducer and activator of transcription. (787 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | STAT3 | Signal transducer and activator of transcription. (781 aa) |
| | TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | HSPA8 | Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | IFNA2 | Interferon alpha 2. (170 aa) |
| | CLEC4M | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). (376 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa) |
| | IL2RA | Interleukin 2 receptor subunit alpha. (272 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | FCGR2B | Uncharacterized protein. (310 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | G3S9G1_GORGO | Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) |
| | RAB9A | RAB9A, member RAS oncogene family. (201 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1229 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | MSN | Moesin. (577 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (414 aa) |
| | STAT1 | Signal transducer and activator of transcription. (777 aa) |
| | CD3G | CD3g molecule. (182 aa) |
| | FAS | Fas cell surface death receptor. (340 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa) |
| | CD28 | CD28 molecule. (220 aa) |
| | CD209 | CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (268 aa) |
| | CSNK2A1 | Casein kinase 2 alpha 1; Belongs to the protein kinase superfamily. (391 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | CCND1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (558 aa) |
| | CD3D | CD3d molecule. (171 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | ENSGGOP00000035522 | Interferon alpha 1. (198 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | IFNA13 | Interferon alpha 13. (195 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ENSGGOP00000049412 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa) |
| | CDKN1B | Uncharacterized protein. (205 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (723 aa) |
| | BBC3 | Uncharacterized protein. (101 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (334 aa) |
| | IFNAR2 | Uncharacterized protein. (519 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
