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| | FDPS | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (419 aa) |
| | KPNA7 | Importin subunit alpha; Functions in nuclear protein import. (516 aa) |
| | TMPRSS11D | Transmembrane protease serine; Belongs to the peptidase S1 family. (418 aa) |
| | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3. (504 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | MX2 | MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa) |
| | MX1 | MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (662 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (446 aa) |
| | NXF3 | Nuclear RNA export factor 3. (531 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | KPNA6 | Importin subunit alpha; Functions in nuclear protein import. (547 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1028 aa) |
| | TMPRSS2 | Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TYK2 | Tyrosine-protein kinase. (1188 aa) |
| | CREBBP | CREB binding protein. (2436 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1087 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (687 aa) |
| | EP300 | E1A binding protein p300. (2416 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (489 aa) |
| | G3R0F2_GORGO | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa) |
| | G3R317_GORGO | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (217 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | G3R516_GORGO | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | RSAD2 | Elp3 domain-containing protein. (361 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (289 aa) |
| | G3R5S5_GORGO | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (440 aa) |
| | TRIM25 | Tripartite motif containing 25. (630 aa) |
| | TRADD | Death domain-containing protein. (251 aa) |
| | KPNA5 | Importin subunit alpha; Functions in nuclear protein import. (539 aa) |
| | NXT1 | NTF2 domain-containing protein. (140 aa) |
| | PABPN1L | Poly(A) binding protein nuclear 1 like, cytoplasmic. (275 aa) |
| | G3RBV4_GORGO | Serine protease 3; Belongs to the peptidase S1 family. (302 aa) |
| | NXT2 | Nuclear transport factor 2 like export factor 2. (197 aa) |
| | G3QFY0_GORGO | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | G3RCR2_GORGO | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa) |
| | ACTG1 | Actin gamma 1. (375 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1131 aa) |
| | G3RDV5_GORGO | Tryptase delta 1; Belongs to the peptidase S1 family. (242 aa) |
| | RAB11A | RAB11A, member RAS oncogene family. (216 aa) |
| | SLC25A5 | Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1025 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | KPNA1 | Importin subunit alpha; Functions in nuclear protein import. (538 aa) |
| | IRF9 | Interferon regulatory factor 9. (392 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | G3RPG3_GORGO | Major histocompatibility complex, class II, DQ beta 1. (261 aa) |
| | NXF1 | Nuclear RNA export factor 1. (619 aa) |
| | G3RQE7_GORGO | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | MHC-DMB | Ig-like domain-containing protein. (263 aa) |
| | IL6 | Interleukin 6. (234 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa) |
| | RNASEL | Ribonuclease L. (741 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | PRSS2 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (214 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | G3S117_GORGO | Major histocompatibility complex, class II, DR beta 5. (266 aa) |
| | IFNA2 | Interferon alpha 2. (170 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | G3S8P9_GORGO | Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1229 aa) |
| | HNRNPUL1 | Heterogeneous nuclear ribonucleoprotein U like 1. (856 aa) |
| | TMPRSS4 | Uncharacterized protein; Belongs to the peptidase S1 family. (435 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (414 aa) |
| | STAT1 | Signal transducer and activator of transcription. (777 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | FAS | Fas cell surface death receptor. (340 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (630 aa) |
| | TLR3 | Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa) |
| | NUP98 | Nucleoporin 98. (1817 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1. (340 aa) |
| | RAB11B | Uncharacterized protein. (221 aa) |
| | G3SJ81_GORGO | Uncharacterized protein. (701 aa) |
| | G3SJ91_GORGO | Major histocompatibility complex, class II, DQ beta 2. (264 aa) |
| | CPSF4L | Cleavage and polyadenylation specific factor 4 like. (179 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (225 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (558 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | ENSGGOP00000035522 | Interferon alpha 1. (198 aa) |
| | ENSGGOP00000036585 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (216 aa) |
| | ICAM1 | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (532 aa) |
| | RAE1 | WD_REPEATS_REGION domain-containing protein. (437 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ENSGGOP00000040685 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (241 aa) |
| | IL33 | Interleukin 33. (270 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | XPO1 | Exportin 1. (1071 aa) |
| | IFNA13 | Interferon alpha 13. (195 aa) |
| | ENSGGOP00000045882 | Actin beta. (378 aa) |
| | ENSGGOP00000046758 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (468 aa) |
| | ENSGGOP00000049412 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (723 aa) |
| | IFNAR2 | Uncharacterized protein. (519 aa) |
