STRINGSTRING
CALM3 CALM3 FOS FOS CSF2 CSF2 UBC UBC CDK4 CDK4 BECN1 BECN1 CD200R1L CD200R1L CASP9 CASP9 GNB3 GNB3 PIK3R5 PIK3R5 GNG3 GNG3 CXCL1 CXCL1 E2F1 E2F1 MAP2K1 MAP2K1 IL6ST IL6ST MAPK13 MAPK13 TRAF3 TRAF3 UBA52 UBA52 IKBKG IKBKG CD200R1 CD200R1 ITPR1 ITPR1 TYK2 TYK2 CREBBP CREBBP CCR8 CCR8 ATG3 ATG3 IKBKB IKBKB GSK3B GSK3B RPS27A RPS27A AKT3 AKT3 PLCG1 PLCG1 GNG4 GNG4 G3QYA4_GORGO G3QYA4_GORGO BECN2 BECN2 EP300 EP300 IFNGR1 IFNGR1 TCF7L1 TCF7L1 CD86 CD86 NFATC4 NFATC4 G3R0F2_GORGO G3R0F2_GORGO CHUK CHUK PIK3CA PIK3CA NFKBIA NFKBIA PIK3CB PIK3CB ANGPT2 ANGPT2 G3R3J7_GORGO G3R3J7_GORGO BAX BAX SYK SYK BID BID MTOR MTOR CCR3 CCR3 E2F3 E2F3 TRADD TRADD GABARAPL2 GABARAPL2 LYN LYN G3RAL4_GORGO G3RAL4_GORGO CCR4 CCR4 GABARAP GABARAP CLEC2B CLEC2B ZFP36 ZFP36 MAPK12 MAPK12 GNG11 GNG11 GNGT1 GNGT1 PDGFB PDGFB IRF9 IRF9 JAK1 JAK1 IFNB1 IFNB1 GABARAPL1 GABARAPL1 PTGS2 PTGS2 G3RQE7_GORGO G3RQE7_GORGO SRC SRC IL6 IL6 MYC MYC NFKB1 NFKB1 CDKN1A CDKN1A BAK1 BAK1 PIK3R3 PIK3R3 EIF2AK2 EIF2AK2 IKBKE IKBKE FADD FADD STAT3 STAT3 CASP3 CASP3 IFNA2 IFNA2 MAPK3 MAPK3 CXCL3 CXCL3 MAPK11 MAPK11 MAPK9 MAPK9 PIK3CG PIK3CG TBK1 TBK1 MAP2K6 MAP2K6 C3 C3 CXCL8 CXCL8 ITPR3 ITPR3 GNB4 GNB4 G3SET6_GORGO G3SET6_GORGO STAT1 STAT1 TNFRSF1A TNFRSF1A FAS FAS RAF1 RAF1 PPP3CB PPP3CB TLR3 TLR3 RELA RELA PLCG2 PLCG2 HCK HCK HIF1A HIF1A CYCS CYCS GNG2 GNG2 TP53 TP53 GNG12 GNG12 TCF7 TCF7 ENSGGOP00000032596 ENSGGOP00000032596 CCND1 CCND1 NRAS NRAS AKT2 AKT2 PPP3CA PPP3CA FGF2 FGF2 RCAN1 RCAN1 IFNAR1 IFNAR1 GNB1 GNB1 ENSGGOP00000035522 ENSGGOP00000035522 PIK3C3 PIK3C3 PREX1 PREX1 ICAM1 ICAM1 MAPKAPK2 MAPKAPK2 GNG13 GNG13 HRAS HRAS ITPR2 ITPR2 PPP3R1 PPP3R1 ENSGGOP00000040207 ENSGGOP00000040207 GNB2 GNB2 MAPK1 MAPK1 MAP2K7 MAP2K7 TCF7L2 TCF7L2 CALML3 CALML3 NFATC2 NFATC2 IRF7 IRF7 ENSGGOP00000044877 ENSGGOP00000044877 GNGT2 GNGT2 IFNA13 IFNA13 GNG7 GNG7 ATG14 ATG14 CTNNB1 CTNNB1 CALML4 CALML4 MAPK8 MAPK8 ENSGGOP00000049412 ENSGGOP00000049412 CCR1 CCR1 PIK3R1 PIK3R1 IFNAR2 IFNAR2 ENSGGOP00000051131 ENSGGOP00000051131 MAPK10 MAPK10 CCR5 CCR5 NFATC1 NFATC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CSF2Colony stimulating factor 2. (144 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
BECN1Beclin 1. (450 aa)
CD200R1LCD200 receptor 1 like. (271 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
GNB3G protein subunit beta 3. (340 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CXCL1C-X-C motif chemokine. (107 aa)
E2F1E2F transcription factor 1. (437 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IL6STFibronectin type-III domain-containing protein. (329 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
UBA52Ubiquitin-like domain-containing protein. (233 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
CD200R1CD200 receptor 1. (348 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2706 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
CREBBPCREB binding protein. (2436 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ATG3Autophagy-related protein 3. (314 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
G3QYA4_GORGOMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (350 aa)
BECN2Beclin 2. (431 aa)
EP300E1A binding protein p300. (2416 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
CD86CD86 molecule. (329 aa)
NFATC4Nuclear factor of activated T cells 4. (920 aa)
G3R0F2_GORGOMitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
ANGPT2Angiopoietin 2. (496 aa)
G3R3J7_GORGOMHC_I-like_Ag-recog domain-containing protein. (187 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
SYKTyrosine-protein kinase. (635 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
E2F3E2F transcription factor 3. (408 aa)
TRADDDeath domain-containing protein. (251 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
LYNTyrosine-protein kinase. (512 aa)
G3RAL4_GORGOMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
CLEC2BC-type lectin domain family 2 member B. (149 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
IRF9Interferon regulatory factor 9. (392 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
IFNB1Interferon beta 1. (187 aa)
GABARAPL1Uncharacterized protein. (117 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SRCTyrosine-protein kinase. (542 aa)
IL6Interleukin 6. (234 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3R3Uncharacterized protein. (507 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IFNA2Interferon alpha 2. (170 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
CXCL3C-X-C motif chemokine. (107 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
TBK1TANK binding kinase 1. (729 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
C3Complement C3. (1663 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
GNB4G protein subunit beta 4. (340 aa)
G3SET6_GORGOC-X-C motif chemokine. (107 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FASFas cell surface death receptor. (340 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
HCKTyrosine-protein kinase. (526 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
GNG2G protein gamma domain-containing protein. (41 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
TCF7HMG box domain-containing protein. (300 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (258 aa)
RCAN1Regulator of calcineurin 1. (276 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
GNB1G protein subunit beta 1. (340 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1658 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (532 aa)
MAPKAPK2Protein kinase domain-containing protein. (374 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa)
PPP3R1Uncharacterized protein. (189 aa)
ENSGGOP00000040207Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
GNB2G protein subunit beta 2. (340 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
TCF7L2HMG box domain-containing protein. (296 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
IRF7Interferon regulatory factor 7. (516 aa)
ENSGGOP00000044877Uncharacterized protein; Belongs to the calmodulin family. (123 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
IFNA13Interferon alpha 13. (195 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ATG14Autophagy related 14. (492 aa)
CTNNB1Catenin beta 1. (781 aa)
CALML4Uncharacterized protein. (196 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
IFNAR2Uncharacterized protein. (519 aa)
ENSGGOP00000051131Uncharacterized protein. (126 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
NFATC1Nuclear factor of activated T cells 1. (948 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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