STRINGSTRING
MAP2K3 MAP2K3 BCL2 BCL2 PSMC4 PSMC4 PSMD11 PSMD11 CDK4 CDK4 CASP9 CASP9 CCNA2 CCNA2 NFKBIB NFKBIB TLR2 TLR2 TNFAIP3 TNFAIP3 E2F1 E2F1 MYD88 MYD88 MAPK13 MAPK13 RBPJL RBPJL TRAF3 TRAF3 SAP30L SAP30L PSMD8 PSMD8 MAP3K14 MAP3K14 IKBKG IKBKG ENTPD3 ENTPD3 GADD45G GADD45G SAP30 SAP30 USP7 USP7 HDAC2 HDAC2 TRAF6 TRAF6 TYK2 TYK2 TAPBP TAPBP CD3E CD3E IKBKB IKBKB PSMC5 PSMC5 NFKB2 NFKB2 FCER2 FCER2 AKT3 AKT3 G3QYA4_GORGO G3QYA4_GORGO TAB1 TAB1 OAS3 OAS3 OAS2 OAS2 CCNE1 CCNE1 ADRM1 ADRM1 HES1 HES1 NFKBIE NFKBIE CHUK CHUK PSMC2 PSMC2 PIK3CA PIK3CA NFKBIA NFKBIA CCND2 CCND2 VIM VIM PIK3CB PIK3CB PSMD7 PSMD7 G3R317_GORGO G3R317_GORGO G3R3J7_GORGO G3R3J7_GORGO BAX BAX SYK SYK BID BID CXCL10 CXCL10 PSMC1 PSMC1 G3R516_GORGO G3R516_GORGO GADD45A GADD45A G3R5S5_GORGO G3R5S5_GORGO TAP1 TAP1 E2F3 E2F3 HDAC1 HDAC1 TRADD TRADD LYN LYN RIPK1 RIPK1 TRAF5 TRAF5 G3RAL4_GORGO G3RAL4_GORGO G3QFY0_GORGO G3QFY0_GORGO G3RCR2_GORGO G3RCR2_GORGO MAPK12 MAPK12 PSMD12 PSMD12 CCNE2 CCNE2 CCND3 CCND3 SKP2 SKP2 PSMD14 PSMD14 IRF9 IRF9 CALR CALR JAK1 JAK1 TAB2 TAB2 CD19 CD19 IFNB1 IFNB1 G3RPG3_GORGO G3RPG3_GORGO G3RQE7_GORGO G3RQE7_GORGO MHC-DMB MHC-DMB G3RQR5_GORGO G3RQR5_GORGO CD247 CD247 CD58 CD58 IRAK1 IRAK1 IL6 IL6 MYC MYC NFKB1 NFKB1 CDKN1A CDKN1A BAK1 BAK1 RELB RELB PIK3R3 PIK3R3 EIF2AK2 EIF2AK2 IKBKE IKBKE PSMD1 PSMD1 FADD FADD STAT3 STAT3 MAP3K7 MAP3K7 IRAK4 IRAK4 CASP3 CASP3 G3S117_GORGO G3S117_GORGO IFNA2 IFNA2 GADD45B GADD45B RUNX3 RUNX3 SNW1 SNW1 MAPK11 MAPK11 PSMD2 PSMD2 MAPK9 MAPK9 DDX58 DDX58 CD40 CD40 TBK1 TBK1 G3S8P9_GORGO G3S8P9_GORGO MAP2K6 MAP2K6 BTK BTK PDIA3 PDIA3 BLNK BLNK CCNA1 CCNA1 B2M B2M PSMD3 PSMD3 OAS1 OAS1 STAT1 STAT1 CD3G CD3G FAS FAS RELA RELA PLCG2 PLCG2 G3SJ91_GORGO G3SJ91_GORGO CYCS CYCS PSMD13 PSMD13 TP53 TP53 ENSGGOP00000032596 ENSGGOP00000032596 CCND1 CCND1 AKT2 AKT2 NEDD4 NEDD4 IFNAR1 IFNAR1 CD3D CD3D APAF1 APAF1 ENSGGOP00000035522 ENSGGOP00000035522 SIN3A SIN3A PSMC6 PSMC6 ICAM1 ICAM1 PSMD4 PSMD4 ENSGGOP00000040207 ENSGGOP00000040207 ENTPD1 ENTPD1 MAP2K7 MAP2K7 RBPJ RBPJ SEM1 SEM1 IRF7 IRF7 IFNA13 IFNA13 TAP2 TAP2 ENTPD8 ENTPD8 POLK POLK BCL2L11 BCL2L11 DDB2 DDB2 MAPK8 MAPK8 ITGAL ITGAL ENSGGOP00000049412 ENSGGOP00000049412 CDKN1B CDKN1B PIK3R1 PIK3R1 IFNAR2 IFNAR2 ENSGGOP00000051193 ENSGGOP00000051193 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
E2F1E2F transcription factor 1. (437 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (471 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
SAP30LSAP30 like. (183 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SAP30Sin3A associated protein 30. (220 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1086 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
TAPBPTAP binding protein. (504 aa)
CD3ECD3e molecule. (207 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
NFKB2Nuclear factor kappa B subunit 2. (902 aa)
FCER2Fc fragment of IgE receptor II. (321 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
G3QYA4_GORGOMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (350 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1087 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ADRM1Adhesion regulating molecule 1. (407 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NFKBIEANK_REP_REGION domain-containing protein. (361 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
G3R317_GORGOMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
G3R3J7_GORGOMHC_I-like_Ag-recog domain-containing protein. (187 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
SYKTyrosine-protein kinase. (635 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
CXCL10C-X-C motif chemokine. (98 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
G3R516_GORGOMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
G3R5S5_GORGOMajor histocompatibility complex, class II, DO beta. (273 aa)
TAP1Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (808 aa)
E2F3E2F transcription factor 3. (408 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
TRADDDeath domain-containing protein. (251 aa)
LYNTyrosine-protein kinase. (512 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
G3RAL4_GORGOMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa)
G3QFY0_GORGOMajor histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
G3RCR2_GORGOMajor histocompatibility complex, class II, DP beta 1. (258 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (436 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
SKP2S-phase kinase associated protein 2. (425 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
IRF9Interferon regulatory factor 9. (392 aa)
CALRCalreticulin. (417 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CD19CD19 molecule. (556 aa)
IFNB1Interferon beta 1. (187 aa)
G3RPG3_GORGOMajor histocompatibility complex, class II, DQ beta 1. (261 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MHC-DMBIg-like domain-containing protein. (263 aa)
G3RQR5_GORGOIg-like domain-containing protein. (117 aa)
CD247CD247 molecule. (164 aa)
CD58CD58 molecule. (250 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IL6Interleukin 6. (234 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RELBRELB proto-oncogene, NF-kB subunit. (579 aa)
PIK3R3Uncharacterized protein. (507 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
G3S117_GORGOMajor histocompatibility complex, class II, DR beta 5. (266 aa)
IFNA2Interferon alpha 2. (170 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
SNW1SNW domain containing 1. (571 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DDX58DExD/H-box helicase 58. (925 aa)
CD40CD40 molecule. (277 aa)
TBK1TANK binding kinase 1. (729 aa)
G3S8P9_GORGOMajor histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
BTKTyrosine-protein kinase. (693 aa)
PDIA3Protein disulfide-isomerase. (383 aa)
BLNKB cell linker. (456 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
OAS12'-5'-oligoadenylate synthetase 1. (414 aa)
STAT1Signal transducer and activator of transcription. (777 aa)
CD3GCD3g molecule. (182 aa)
FASFas cell surface death receptor. (340 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
G3SJ91_GORGOMajor histocompatibility complex, class II, DQ beta 2. (264 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (399 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (558 aa)
CD3DCD3d molecule. (171 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP00000035522Interferon alpha 1. (198 aa)
SIN3AUncharacterized protein. (154 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (532 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (391 aa)
ENSGGOP00000040207Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
SEM1Uncharacterized protein. (119 aa)
IRF7Interferon regulatory factor 7. (516 aa)
IFNA13Interferon alpha 13. (195 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (724 aa)
ENTPD8Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (306 aa)
POLKDNA polymerase kappa. (897 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1181 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
CDKN1BUncharacterized protein. (205 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
IFNAR2Uncharacterized protein. (519 aa)
ENSGGOP00000051193Uncharacterized protein. (73 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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