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| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (446 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | RBPJL | Recombination signal binding protein for immunoglobulin kappa J region like. (471 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | SAP30L | SAP30 like. (183 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (350 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | SAP30 | Sin3A associated protein 30. (220 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1086 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | TYK2 | Tyrosine-protein kinase. (1188 aa) |
| | TAPBP | TAP binding protein. (504 aa) |
| | CD3E | CD3e molecule. (207 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (902 aa) |
| | FCER2 | Fc fragment of IgE receptor II. (321 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | G3QYA4_GORGO | Major histocompatibility complex, class I, G; Belongs to the MHC class I family. (350 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1087 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (687 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | ADRM1 | Adhesion regulating molecule 1. (407 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | NFKBIE | ANK_REP_REGION domain-containing protein. (361 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | G3R317_GORGO | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | G3R3J7_GORGO | MHC_I-like_Ag-recog domain-containing protein. (187 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (217 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | G3R516_GORGO | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | G3R5S5_GORGO | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | TAP1 | Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. (808 aa) |
| | E2F3 | E2F transcription factor 3. (408 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | TRADD | Death domain-containing protein. (251 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | G3RAL4_GORGO | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa) |
| | G3QFY0_GORGO | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | G3RCR2_GORGO | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (312 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (436 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | SKP2 | S-phase kinase associated protein 2. (425 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | IRF9 | Interferon regulatory factor 9. (392 aa) |
| | CALR | Calreticulin. (417 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CD19 | CD19 molecule. (556 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | G3RPG3_GORGO | Major histocompatibility complex, class II, DQ beta 1. (261 aa) |
| | G3RQE7_GORGO | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | MHC-DMB | Ig-like domain-containing protein. (263 aa) |
| | G3RQR5_GORGO | Ig-like domain-containing protein. (117 aa) |
| | CD247 | CD247 molecule. (164 aa) |
| | CD58 | CD58 molecule. (250 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | IL6 | Interleukin 6. (234 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (579 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | STAT3 | Signal transducer and activator of transcription. (781 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | G3S117_GORGO | Major histocompatibility complex, class II, DR beta 5. (266 aa) |
| | IFNA2 | Interferon alpha 2. (170 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa) |
| | SNW1 | SNW domain containing 1. (571 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | CD40 | CD40 molecule. (277 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | G3S8P9_GORGO | Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (256 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa) |
| | BTK | Tyrosine-protein kinase. (693 aa) |
| | PDIA3 | Protein disulfide-isomerase. (383 aa) |
| | BLNK | B cell linker. (456 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (414 aa) |
| | STAT1 | Signal transducer and activator of transcription. (777 aa) |
| | CD3G | CD3g molecule. (182 aa) |
| | FAS | Fas cell surface death receptor. (340 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | G3SJ91_GORGO | Major histocompatibility complex, class II, DQ beta 2. (264 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (399 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | CCND1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1319 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (558 aa) |
| | CD3D | CD3d molecule. (171 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | ENSGGOP00000035522 | Interferon alpha 1. (198 aa) |
| | SIN3A | Uncharacterized protein. (154 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa) |
| | ICAM1 | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (532 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (391 aa) |
| | ENSGGOP00000040207 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (488 aa) |
| | SEM1 | Uncharacterized protein. (119 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | IFNA13 | Interferon alpha 13. (195 aa) |
| | TAP2 | Transporter 2, ATP binding cassette subfamily B member. (724 aa) |
| | ENTPD8 | Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (306 aa) |
| | POLK | DNA polymerase kappa. (897 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (430 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ITGAL | Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1181 aa) |
| | ENSGGOP00000049412 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa) |
| | CDKN1B | Uncharacterized protein. (205 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (723 aa) |
| | IFNAR2 | Uncharacterized protein. (519 aa) |
| | ENSGGOP00000051193 | Uncharacterized protein. (73 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
