STRINGSTRING
ETV4 ETV4 ZBTB16 ZBTB16 FLT3 FLT3 KMT2A KMT2A CSF2 CSF2 IL3 IL3 SIX1 SIX1 ETV6 ETV6 IGFBP3 IGFBP3 ETV5 ETV5 DDIT3 DDIT3 LDB1 LDB1 CCNA2 CCNA2 HOXA9 HOXA9 IL2RB IL2RB TRAF1 TRAF1 MEN1 MEN1 RARA RARA EYA1 EYA1 PAX5 PAX5 ITGAM ITGAM PAX7 PAX7 DEFA1B DEFA1B PER2 PER2 KLF3 KLF3 TMPRSS2 TMPRSS2 IGF1 IGF1 GADD45G GADD45G MYCN MYCN HDAC2 HDAC2 BIRC3 BIRC3 SPI1 SPI1 DOT1L DOT1L SLC45A3 SLC45A3 SPINT1 SPINT1 CEBPE CEBPE FOXO1 FOXO1 BIRC2 BIRC2 NGFR NGFR CD86 CD86 FLT1 FLT1 FUT8 FUT8 PBX3 PBX3 CCND2 CCND2 GRIA3 GRIA3 RXRB RXRB HPGD HPGD JUP JUP MMP3 MMP3 BAX BAX CD14 CD14 ATM ATM GADD45A GADD45A FEV FEV MLLT1 MLLT1 DEFA4 DEFA4 DEFA6 DEFA6 CDK9 CDK9 PBX1 PBX1 IL1R2 IL1R2 HDAC1 HDAC1 ZBTB17 ZBTB17 IGF1R IGF1R G3RB29_GORGO G3RB29_GORGO MMP9 MMP9 PRCC PRCC NSD2 NSD2 PLAU PLAU PAX3 PAX3 JMJD1C JMJD1C DEFA5 DEFA5 WNT16 WNT16 TGFBR2 TGFBR2 CDKN2C CDKN2C CSF1R CSF1R AFF1 AFF1 FUS FUS G3RQR5_GORGO G3RQR5_GORGO IL6 IL6 MYC MYC BCL11B BCL11B NFKB1 NFKB1 CDKN1A CDKN1A BAK1 BAK1 G3RSZ1_GORGO G3RSZ1_GORGO ELK4 ELK4 BCL2L1 BCL2L1 H3C13 H3C13 NFKBIZ NFKBIZ PTK2 PTK2 GADD45B GADD45B TLX1 TLX1 PROM1 PROM1 RXRG RXRG CD40 CD40 LYL1 LYL1 CXCL8 CXCL8 SMAD1 SMAD1 DUSP6 DUSP6 CCNA1 CCNA1 ZEB1 ZEB1 H3-3A H3-3A BMP2K BMP2K BMI1 BMI1 RELA RELA HOXA11 HOXA11 HHEX HHEX PAX8 PAX8 G3SCC9_GORGO G3SCC9_GORGO TP53 TP53 ITGB7 ITGB7 CCNT2 CCNT2 MAX MAX PPARG PPARG WT1 WT1 BCL6 BCL6 HOXA10 HOXA10 MEIS1 MEIS1 RUNX1 RUNX1 FCGR1A FCGR1A BCL2A1 BCL2A1 SIN3A SIN3A LMO2 LMO2 TFE3 TFE3 BAIAP3 BAIAP3 CEBPA CEBPA PDGFA PDGFA SS18 SS18 MITF MITF HMGA2 HMGA2 NTRK1 NTRK1 RXRA RXRA MET MET CEBPB CEBPB ERG ERG ATF1 ATF1 FLI1 FLI1 POLK POLK DDX5 DDX5 NUPR1 NUPR1 MPO MPO DDB2 DDB2 CDKN1B CDKN1B ARNT2 ARNT2 RUNX2 RUNX2 RUNX1T1 RUNX1T1 CDK14 CDK14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ETV4ETS variant 4. (484 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3982 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
SIX1Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of nume [...] (284 aa)
ETV6ETS variant 6. (452 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
ETV5ETS variant 5. (510 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
LDB1LIM domain binding 1. (411 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
TRAF1TNF receptor-associated factor. (416 aa)
MEN1Menin 1. (615 aa)
RARAUncharacterized protein. (624 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
PAX5Paired box 5. (396 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
PAX7Paired box 7. (520 aa)
DEFA1BDEFENSIN domain-containing protein. (94 aa)
PER2Period circadian regulator 2. (1255 aa)
KLF3Kruppel like factor 3. (345 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa)
IGF1IlGF domain-containing protein. (196 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MYCNMYCN proto-oncogene, bHLH transcription factor. (464 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1537 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (529 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
FOXO1Forkhead box O1. (655 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
NGFRNerve growth factor receptor. (427 aa)
CD86CD86 molecule. (329 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1302 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
PBX3Homeobox domain-containing protein. (450 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
RXRBRetinoid X receptor beta. (537 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
JUPJunction plakoglobin. (745 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FEVFEV transcription factor, ETS family member. (238 aa)
MLLT1MLLT1 super elongation complex subunit. (556 aa)
DEFA4Defensin alpha 4. (97 aa)
DEFA6Defensin alpha 6. (100 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
PBX1PBX homeobox 1. (430 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ZBTB17Zinc finger and BTB domain containing 17. (800 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
G3RB29_GORGOGranzyme B; Belongs to the peptidase S1 family. (247 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
PLAUPlasminogen activator, urokinase. (431 aa)
PAX3Paired box 3. (486 aa)
JMJD1CJumonji domain containing 1C. (2451 aa)
DEFA5Defensin alpha 5. (94 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
AFF1AF4/FMR2 family member 1. (1219 aa)
FUSFUS RNA binding protein. (523 aa)
G3RQR5_GORGOIg-like domain-containing protein. (117 aa)
IL6Interleukin 6. (234 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
G3RSZ1_GORGOKRAB-related domain-containing protein. (188 aa)
ELK4ETS transcription factor ELK4. (431 aa)
BCL2L1BCL2 like 1. (233 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
NFKBIZNFKB inhibitor zeta. (718 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TLX1T cell leukemia homeobox 1. (335 aa)
PROM1Prominin 1. (865 aa)
RXRGRetinoid X receptor gamma. (463 aa)
CD40CD40 molecule. (277 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1108 aa)
H3-3AHistone H3; Belongs to the histone H3 family. (136 aa)
BMP2KBMP2 inducible kinase. (1153 aa)
BMI1RING-type domain-containing protein. (326 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
HOXA11Homeobox A11. (315 aa)
HHEXHomeobox domain-containing protein. (98 aa)
PAX8Paired domain-containing protein. (457 aa)
G3SCC9_GORGOHistone H3; Belongs to the histone H3 family. (136 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (730 aa)
MAXMYC associated factor X. (148 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
WT1Uncharacterized protein. (516 aa)
BCL6BCL6 transcription repressor. (706 aa)
HOXA10Homeobox A10. (414 aa)
MEIS1Homeobox domain-containing protein. (463 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
FCGR1AUncharacterized protein. (374 aa)
BCL2A1BCL2 related protein A1. (196 aa)
SIN3AUncharacterized protein. (154 aa)
LMO2LIM domain only 2. (222 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
BAIAP3BAI1 associated protein 3. (1187 aa)
CEBPABZIP domain-containing protein. (141 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (234 aa)
SS18SS18 subunit of BAF chromatin remodeling complex. (418 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
RXRARetinoid X receptor alpha. (463 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1409 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
ERGETS transcription factor ERG. (486 aa)
ATF1Activating transcription factor 1. (270 aa)
FLI1Fli-1 proto-oncogene, ETS transcription factor. (452 aa)
POLKDNA polymerase kappa. (897 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
MPOMyeloperoxidase. (747 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
CDKN1BUncharacterized protein. (205 aa)
ARNT2Uncharacterized protein. (759 aa)
RUNX2Runt domain-containing protein. (541 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (663 aa)
CDK14Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (469 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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