STRINGSTRING
UBR4 UBR4 TBPL2 TBPL2 CDK4 CDK4 YWHAQ YWHAQ VDAC3 VDAC3 CCNA2 CCNA2 TRAF1 TRAF1 EGR3 EGR3 GTF2A1 GTF2A1 IL6ST IL6ST RBPJL RBPJL CREB3L2 CREB3L2 TRAF3 TRAF3 YWHAB YWHAB IKBKG IKBKG DLG1 DLG1 EGR2 EGR2 USP7 USP7 PMAIP1 PMAIP1 HDAC2 HDAC2 KAT2A KAT2A RBL1 RBL1 CREB3L4 CREB3L4 ACTN4 ACTN4 CREBBP CREBBP YWHAH YWHAH CCR8 CCR8 GRB2 GRB2 NFKB2 NFKB2 CREB3 CREB3 G3QXG0_GORGO G3QXG0_GORGO HDAC11 HDAC11 G3QYA4_GORGO G3QYA4_GORGO EP300 EP300 CCNE1 CCNE1 G3QZQ7_GORGO G3QZQ7_GORGO GTF2H3 GTF2H3 PIK3CA PIK3CA NFKBIA NFKBIA CCND2 CCND2 PIK3CB PIK3CB SND1 SND1 DNAJA3 DNAJA3 G3R3J7_GORGO G3R3J7_GORGO ATF4 ATF4 GSN GSN BAX BAX SYK SYK CDC20 CDC20 PSMC1 PSMC1 LTBR LTBR CCR3 CCR3 HDAC1 HDAC1 TBP TBP TRADD TRADD LYN LYN TRAF5 TRAF5 G3RAL4_GORGO G3RAL4_GORGO RHOA RHOA VAC14 VAC14 CDK1 CDK1 CCR4 CCR4 ATP6V0D2 ATP6V0D2 GTF2H4 GTF2H4 HDAC10 HDAC10 CCNE2 CCNE2 CCND3 CCND3 CREB3L1 CREB3L1 SCIN SCIN SKP2 SKP2 IRF9 IRF9 HDAC3 HDAC3 HDAC7 HDAC7 JAK1 JAK1 CHEK1 CHEK1 GTF2H1 GTF2H1 SRC SRC CHD4 CHD4 YWHAZ YWHAZ NFKB1 NFKB1 CDKN1A CDKN1A BAK1 BAK1 PIK3R3 PIK3R3 HDAC5 HDAC5 EIF2AK2 EIF2AK2 G3RU19_GORGO G3RU19_GORGO G3RVL7_GORGO G3RVL7_GORGO G3RVS4_GORGO G3RVS4_GORGO KAT2B KAT2B GTF2B GTF2B STAT3 STAT3 H4C14 H4C14 GTF2E2 GTF2E2 CASP3 CASP3 GTF2E1 GTF2E1 MAPK3 MAPK3 G3S2U1_GORGO G3S2U1_GORGO SNW1 SNW1 HDAC9 HDAC9 C3 C3 PRKACB PRKACB CCNA1 CCNA1 G3SDT0_GORGO G3SDT0_GORGO G3SEH8_GORGO G3SEH8_GORGO HDAC4 HDAC4 H2BC13 H2BC13 G3SG93_GORGO G3SG93_GORGO RELA RELA POLB POLB DDX3X DDX3X G3SK93_GORGO G3SK93_GORGO ENSGGOP00000029268 ENSGGOP00000029268 ENSGGOP00000029537 ENSGGOP00000029537 ENSGGOP00000029862 ENSGGOP00000029862 TP53 TP53 CDKN2A CDKN2A ATF2 ATF2 ENSGGOP00000032596 ENSGGOP00000032596 CCND1 CCND1 NRAS NRAS ENSGGOP00000034298 ENSGGOP00000034298 ENSGGOP00000034747 ENSGGOP00000034747 TBPL1 TBPL1 ATF6B ATF6B G3RXM3_GORGO G3RXM3_GORGO MAPKAPK2 MAPKAPK2 CDKN2B CDKN2B HRAS HRAS UBE3A UBE3A BAD BAD ENSGGOP00000040293 ENSGGOP00000040293 MAPK1 MAPK1 YWHAE YWHAE SP100-2 SP100-2 RBPJ RBPJ CDC42 CDC42 IRF7 IRF7 MAD1L1 MAD1L1 YWHAG YWHAG HPN HPN GTF2A2 GTF2A2 DDB1 DDB1 ENSGGOP00000048419 ENSGGOP00000048419 PKM PKM CDKN1B CDKN1B HDAC6 HDAC6 RBL2 RBL2 PIK3R1 PIK3R1 ACTN1 ACTN1 CCR5 CCR5 SCRIB SCRIB H2BC12 H2BC12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBR4UBR-type domain-containing protein. (5183 aa)
TBPL2TATA-box binding protein like 2. (375 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
TRAF1TNF receptor-associated factor. (416 aa)
EGR3Early growth response 3. (349 aa)
GTF2A1General transcription factor IIA subunit 1. (370 aa)
IL6STFibronectin type-III domain-containing protein. (329 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (471 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
EGR2Early growth response 2. (476 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1086 aa)
PMAIP1Uncharacterized protein. (150 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
RBL1RB transcriptional corepressor like 1. (1066 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
ACTN4Actinin alpha 4. (931 aa)
CREBBPCREB binding protein. (2436 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NFKB2Nuclear factor kappa B subunit 2. (902 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
G3QXG0_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
HDAC11Histone deacetylase 11. (347 aa)
G3QYA4_GORGOMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (350 aa)
EP300E1A binding protein p300. (2416 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
G3QZQ7_GORGOH2B histone family member W, testis specific; Belongs to the histone H2B family. (174 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
G3R3J7_GORGOMHC_I-like_Ag-recog domain-containing protein. (187 aa)
ATF4Activating transcription factor 4. (351 aa)
GSNGelsolin. (787 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
SYKTyrosine-protein kinase. (635 aa)
CDC20Cell division cycle 20. (499 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
LTBRLymphotoxin beta receptor. (435 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
TBPTATA-box binding protein. (332 aa)
TRADDDeath domain-containing protein. (251 aa)
LYNTyrosine-protein kinase. (512 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
G3RAL4_GORGOMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa)
RHOAUncharacterized protein. (179 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
HDAC10Histone deacetylase 10. (669 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
SCINScinderin. (715 aa)
SKP2S-phase kinase associated protein 2. (425 aa)
IRF9Interferon regulatory factor 9. (392 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
CHEK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
SRCTyrosine-protein kinase. (542 aa)
CHD4Uncharacterized protein. (1912 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3R3Uncharacterized protein. (507 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
G3RU19_GORGOHistone H2B; Belongs to the histone H2B family. (127 aa)
G3RVL7_GORGOHistone H2B; Belongs to the histone H2B family. (127 aa)
G3RVS4_GORGOSignal transducer and activator of transcription. (787 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (820 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
H4C14Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
GTF2E1General transcription factor IIE subunit 1. (439 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
G3S2U1_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
SNW1SNW domain containing 1. (571 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
C3Complement C3. (1663 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
G3SDT0_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
G3SEH8_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
G3SG93_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
G3SK93_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSGGOP00000029268Uncharacterized protein. (93 aa)
ENSGGOP00000029537Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSGGOP00000029862Histone H2B; Belongs to the histone H2B family. (162 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (167 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSGGOP00000034298Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSGGOP00000034747Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
G3RXM3_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
MAPKAPK2Protein kinase domain-containing protein. (374 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ENSGGOP00000040293Histone H2B; Belongs to the histone H2B family. (126 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
SP100-2SP100 nuclear antigen. (885 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
CDC42Cell division cycle 42. (191 aa)
IRF7Interferon regulatory factor 7. (516 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (699 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (250 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
ENSGGOP00000048419Histone H2B; Belongs to the histone H2B family. (167 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
CDKN1BUncharacterized protein. (205 aa)
HDAC6Histone deacetylase 6. (1218 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
ACTN1Actinin alpha 1. (914 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
SCRIBScribble planar cell polarity protein. (1658 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (126 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.