STRINGSTRING
COL4A4 COL4A4 BCL2 BCL2 PTEN PTEN ITGA2 ITGA2 CDK4 CDK4 CASP9 CASP9 TRAF1 TRAF1 COL4A3 COL4A3 E2F1 E2F1 TRAF3 TRAF3 IKBKG IKBKG GADD45G GADD45G BIRC3 BIRC3 TRAF6 TRAF6 LAMA3 LAMA3 IKBKB IKBKB BIRC8 BIRC8 AKT3 AKT3 BIRC2 BIRC2 BIRC7 BIRC7 LAMB3 LAMB3 CCNE1 CCNE1 XIAP XIAP CHUK CHUK PIK3CA PIK3CA NFKBIA NFKBIA PIK3CB PIK3CB RXRB RXRB BAX BAX GADD45A GADD45A E2F3 E2F3 COL4A5 COL4A5 ZBTB17 ZBTB17 COL4A1 COL4A1 COL4A2 COL4A2 TRAF5 TRAF5 ITGA2B ITGA2B CKS1B CKS1B ITGA3 ITGA3 LAMC2 LAMC2 LAMB2 LAMB2 CCNE2 CCNE2 LAMA4 LAMA4 FN1 FN1 SKP2 SKP2 LAMA1 LAMA1 TRAF4 TRAF4 LAMB4 LAMB4 LAMC3 LAMC3 PTGS2 PTGS2 G3RQE7_GORGO G3RQE7_GORGO NOS2 NOS2 MYC MYC NFKB1 NFKB1 CDKN1A CDKN1A BAK1 BAK1 PIK3R3 PIK3R3 BCL2L1 BCL2L1 CKS2 CKS2 CASP3 CASP3 PTK2 PTK2 GADD45B GADD45B LAMC1 LAMC1 RXRG RXRG RARB RARB COL4A6 COL4A6 RELA RELA CYCS CYCS TP53 TP53 MAX MAX ENSGGOP00000032596 ENSGGOP00000032596 CCND1 CCND1 AKT2 AKT2 LAMB1 LAMB1 ITGB1 ITGB1 APAF1 APAF1 CDKN2B CDKN2B RXRA RXRA ITGAV ITGAV ITGA6 ITGA6 POLK POLK DDB2 DDB2 ENSGGOP00000049412 ENSGGOP00000049412 CDKN1B CDKN1B PIK3R1 PIK3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL4A4Collagen type IV alpha 4 chain. (1690 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
TRAF1TNF receptor-associated factor. (416 aa)
COL4A3Collagen type IV alpha 3 chain. (1578 aa)
E2F1E2F transcription factor 1. (437 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LAMA3Laminin subunit alpha 3. (3152 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
BIRC8Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
XIAPUncharacterized protein. (371 aa)
CHUKIKKbetaNEMObind domain-containing protein. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
RXRBRetinoid X receptor beta. (537 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
E2F3E2F transcription factor 3. (408 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
ZBTB17Zinc finger and BTB domain containing 17. (800 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
FN1Fibronectin 1. (2477 aa)
SKP2S-phase kinase associated protein 2. (425 aa)
LAMA1Laminin subunit alpha 1. (3076 aa)
TRAF4TNF receptor-associated factor. (470 aa)
LAMB4Laminin subunit beta 4. (1761 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3R3Uncharacterized protein. (507 aa)
BCL2L1BCL2 like 1. (233 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
RXRGRetinoid X receptor gamma. (463 aa)
RARBRetinoic acid receptor beta. (448 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa)
MAXMYC associated factor X. (148 aa)
ENSGGOP00000032596CCHC NOA-type domain-containing protein. (417 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LAMB1Laminin subunit beta 1. (1791 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
RXRARetinoid X receptor alpha. (463 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1002 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
POLKDNA polymerase kappa. (897 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
CDKN1BUncharacterized protein. (205 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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