STRINGSTRING
LOC100967578 LOC100967578 CYP2A13 CYP2A13 RGS22 RGS22 CBR3 CBR3 CYP4F11 CYP4F11 NAT2 NAT2 NAT1 NAT1 HSD11B1L HSD11B1L UGT2B4 UGT2B4 LOC100988273 LOC100988273 CH25H CH25H SLC35A2 SLC35A2 SULT1E1 SULT1E1 STS STS LOC100969990 LOC100969990 LOC100974522 LOC100974522 ENSPPAP00000009371 ENSPPAP00000009371 CYP1A2 CYP1A2 CYP4F12 CYP4F12 LOC100990187 LOC100990187 AKR1C3 AKR1C3 HSD3B7 HSD3B7 HSD17B7 HSD17B7 NR1I2 NR1I2 HSD3B1 HSD3B1 SRD5A3 SRD5A3 HSD17B6 HSD17B6 FDFT1 FDFT1 CYP19A1 CYP19A1 ENSPPAP00000013126 ENSPPAP00000013126 LBR LBR FBXO43 FBXO43 CYP2S1 CYP2S1 TM7SF2 TM7SF2 LOC100975985 LOC100975985 DHRS11 DHRS11 CYP4A22 CYP4A22 CYP27B1 CYP27B1 CYP26B1 CYP26B1 LOC100980372 LOC100980372 CYP2B6 CYP2B6 ENSPPAP00000017468 ENSPPAP00000017468 ENSPPAP00000018142 ENSPPAP00000018142 CBR1 CBR1 AKR1C4 AKR1C4 SRD5A2 SRD5A2 AKR1C1 AKR1C1 CYP17A1 CYP17A1 UGT2A3 UGT2A3 CYP11A1 CYP11A1 CYP4B1 CYP4B1 KCNH6 KCNH6 UGT2B11 UGT2B11 HMGCR HMGCR LOC100984876 LOC100984876 DHCR24 DHCR24 LSS LSS HSD11B2 HSD11B2 CYP1A1 CYP1A1 CYP2E1 CYP2E1 CYP11B2 CYP11B2 LOC100980327 LOC100980327 CYP46A1 CYP46A1 ABCB1 ABCB1 CYP26C1 CYP26C1 SIGMAR1 SIGMAR1 VDR VDR CYP8B1 CYP8B1 CYP39A1 CYP39A1 MSMO1 MSMO1 LOC100976704 LOC100976704 HSD17B2 HSD17B2 ERG28 ERG28 SULT2B1 SULT2B1 LOC100991744 LOC100991744 SRD5A1 SRD5A1 CYP7B1 CYP7B1 CYP24A1 CYP24A1 CYP3A4 CYP3A4 DHCR7 DHCR7 CYP3A5 CYP3A5 ENSPPAP00000032474 ENSPPAP00000032474 HSD3B2 HSD3B2 NSDHL NSDHL FAXDC2 FAXDC2 CES2 CES2 LOC100968405 LOC100968405 HSD17B3 HSD17B3 UGT3A1 UGT3A1 UGT2B15 UGT2B15 CYP4A11 CYP4A11 LOC100967379 LOC100967379 ENSPPAP00000036109 ENSPPAP00000036109 CYP51A1 CYP51A1 ENSPPAP00000036439 ENSPPAP00000036439 LOC100984524 LOC100984524 PMVK PMVK EBP EBP HSD17B1 HSD17B1 LOC100996034 LOC100996034 MVK MVK CYP2R1 CYP2R1 ENSPPAP00000041060 ENSPPAP00000041060 HSD11B1 HSD11B1 HMGCS1 HMGCS1 ENSPPAP00000041730 ENSPPAP00000041730 ENSPPAP00000042309 ENSPPAP00000042309 SC5D SC5D AKR1D1 AKR1D1 SQLE SQLE UGT1A3 UGT1A3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100967578Uncharacterized protein. (415 aa)
CYP2A13Cytochrome P450 family 2 subfamily A member 13; Belongs to the cytochrome P450 family. (494 aa)
RGS22Regulator of G protein signaling 22. (1264 aa)
CBR3Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
CYP4F11Cytochrome P450 family 4 subfamily F member 11; Belongs to the cytochrome P450 family. (524 aa)
NAT2Arylamine N-acetyltransferase 2; Belongs to the arylamine N-acetyltransferase family. (290 aa)
NAT1N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family. (348 aa)
HSD11B1LHydroxysteroid 11-beta dehydrogenase 1 like. (334 aa)
UGT2B4UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
LOC100988273Uncharacterized protein. (289 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (272 aa)
SLC35A2Solute carrier family 35 member A2. (421 aa)
SULT1E1Sulfotransferase; Belongs to the sulfotransferase 1 family. (310 aa)
STSSteroid sulfatase. (590 aa)
LOC100969990Uncharacterized protein. (659 aa)
LOC100974522Uncharacterized protein; Belongs to the cytochrome P450 family. (343 aa)
ENSPPAP00000009371Uncharacterized protein; Belongs to the cytochrome P450 family. (470 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (517 aa)
CYP4F12Cytochrome P450 family 4 subfamily F member 12; Belongs to the cytochrome P450 family. (524 aa)
LOC1009901873Beta_HSD domain-containing protein. (448 aa)
AKR1C3Aldo-keto reductase family 1 member C3. (323 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (369 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (335 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (473 aa)
HSD3B1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (373 aa)
SRD5A3Steroid 5 alpha-reductase 3. (318 aa)
HSD17B6Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (465 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
ENSPPAP000000131263Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (359 aa)
LBRLamin B receptor. (615 aa)
FBXO43F-box protein 43. (708 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (504 aa)
TM7SF2Transmembrane 7 superfamily member 2. (416 aa)
LOC100975985Uncharacterized protein. (503 aa)
DHRS11Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (234 aa)
CYP4A22Cytochrome P450 family 4 subfamily A member 22; Belongs to the cytochrome P450 family. (519 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (495 aa)
LOC100980372Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (517 aa)
CYP2B6Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (491 aa)
ENSPPAP00000017468Uncharacterized protein. (336 aa)
ENSPPAP00000018142Uncharacterized protein. (159 aa)
CBR1Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
AKR1C4Aldo-keto reductase family 1 member C4. (323 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
AKR1C1Aldo-keto reductase family 1 member C1. (295 aa)
CYP17A1Uncharacterized protein; Belongs to the cytochrome P450 family. (350 aa)
UGT2A3UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
UGT2B11UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (911 aa)
LOC100984876Uncharacterized protein. (372 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (732 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (379 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (531 aa)
CYP11B2Cytochrome P450 family 11 subfamily B member 2; Belongs to the cytochrome P450 family. (429 aa)
LOC100980327Uncharacterized protein. (437 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (500 aa)
ABCB1ATP binding cassette subfamily B member 1. (1220 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (455 aa)
SIGMAR1Uncharacterized protein. (134 aa)
VDRVitamin D receptor. (477 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (496 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (471 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
LOC100976704UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa)
ERG28Ergosterol biosynthesis 28 homolog. (140 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (365 aa)
LOC100991744Uncharacterized protein. (506 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (484 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
CYP3A4Cytochrome P450 family 3 subfamily A member 4. (503 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
CYP3A5Cytochrome P450 family 3 subfamily A member 5. (502 aa)
ENSPPAP00000032474Uncharacterized protein; Belongs to the cytochrome P450 family. (481 aa)
HSD3B2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (372 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (310 aa)
CES2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (663 aa)
LOC100968405Flavin-containing monooxygenase. (484 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
UGT3A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (407 aa)
UGT2B15UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
CYP4A11Cytochrome P450 family 4 subfamily A member 11; Belongs to the cytochrome P450 family. (518 aa)
LOC100967379Uncharacterized protein. (393 aa)
ENSPPAP000000361093Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (359 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (509 aa)
ENSPPAP000000364393Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (329 aa)
LOC100984524Uncharacterized protein. (372 aa)
PMVKPhosphomevalonate kinase. (192 aa)
EBPEXPERA domain-containing protein. (203 aa)
HSD17B1Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (351 aa)
LOC100996034Uncharacterized protein; Belongs to the cytochrome P450 family. (431 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
ENSPPAP00000041060Uncharacterized protein. (229 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (601 aa)
ENSPPAP00000041730Uncharacterized protein. (97 aa)
ENSPPAP00000042309Uncharacterized protein. (514 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
AKR1D1Aldo-keto reductase family 1 member D1. (326 aa)
SQLESqualene epoxidase. (573 aa)
UGT1A3UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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