STRINGSTRING
EGF EGF FGF9 FGF9 GFRA2 GFRA2 ZAP70 ZAP70 MATK MATK PIK3R3 PIK3R3 CD84 CD84 PDGFA PDGFA PAG1 PAG1 CD3D CD3D GDNF GDNF STAP2 STAP2 KLB KLB FLT3 FLT3 PECAM1 PECAM1 IRS1 IRS1 FLT3LG FLT3LG NTF4 NTF4 FGFBP1 FGFBP1 FGF19 FGF19 VAV3 VAV3 CD3G CD3G ENSPPAP00000006969 ENSPPAP00000006969 FCER1G FCER1G CD72 CD72 VEGFA VEGFA GRAP2 GRAP2 PTPN1 PTPN1 PTPN6 PTPN6 ENSPPAP00000009275 ENSPPAP00000009275 ANGPT4 ANGPT4 FRS2 FRS2 PTK6 PTK6 PTPN18 PTPN18 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA INSR INSR CSK CSK SHC3 SHC3 GRAPL GRAPL BDNF BDNF FGR FGR CLEC7A CLEC7A NRG1 NRG1 RALGPS1 RALGPS1 PDGFB PDGFB ANGPTL1 ANGPTL1 GAB2 GAB2 KL KL TEC TEC ENSPPAP00000014225 ENSPPAP00000014225 LYN LYN SHC1 SHC1 CD2 CD2 FCGR2A FCGR2A INPP5D INPP5D ENSPPAP00000015671 ENSPPAP00000015671 PGF PGF SLAMF1 SLAMF1 LCK LCK FGF20 FGF20 FGFR1 FGFR1 FGF5 FGF5 KITLG KITLG FGF22 FGF22 ITK ITK GFRA1 GFRA1 PIK3CB PIK3CB ANGPT2 ANGPT2 CD3E CD3E PLCG1 PLCG1 PDGFRA PDGFRA SRMS SRMS PDGFRL PDGFRL KHDRBS2 KHDRBS2 CD101 CD101 KIT KIT BTC BTC FLT1 FLT1 NRG4 NRG4 INSRR INSRR FGF21 FGF21 NRG3 NRG3 FGFRL1 FGFRL1 PDGFD PDGFD PIK3R6 PIK3R6 SLAMF7 SLAMF7 FGF16 FGF16 FGF23 FGF23 RET RET FGFR3 FGFR3 DOK4 DOK4 TEK TEK FGF11 FGF11 PTPRC PTPRC NTRK1 NTRK1 FGFR2 FGFR2 HGF HGF SORT1 SORT1 ENSPPAP00000024034 ENSPPAP00000024034 NRG2 NRG2 STYK1 STYK1 CD244 CD244 ERBB3 ERBB3 LCP2 LCP2 PIK3CD PIK3CD PTPN11 PTPN11 ENSPPAP00000025160 ENSPPAP00000025160 FGF13 FGF13 FYN FYN PTPN22 PTPN22 PIK3R5 PIK3R5 ANGPT1 ANGPT1 SLAMF6 SLAMF6 SORCS2 SORCS2 ZNRF1 ZNRF1 VAV1 VAV1 TIE1 TIE1 CD58 CD58 FGFR4 FGFR4 FGF7 FGF7 CD52 CD52 CD22 CD22 TXK TXK PDGFRB PDGFRB LAT LAT VAV2 VAV2 ENSPPAP00000029143 ENSPPAP00000029143 SYK SYK NTRK2 NTRK2 HCK HCK MET MET LOC100984838 LOC100984838 CD53 CD53 PSPN PSPN FGF14 FGF14 CLEC11A CLEC11A BTK BTK VEGFB VEGFB CD48 CD48 YES1 YES1 PDGFC PDGFC DOK2 DOK2 FGF10 FGF10 GAB1 GAB1 SH2D1A SH2D1A FER FER PLCG2 PLCG2 NGFR NGFR FCGR1A FCGR1A IRS4 IRS4 NGF NGF FGF8 FGF8 GRAP GRAP BLNK BLNK GP6 GP6 FGF6 FGF6 LOC103785316 LOC103785316 SOS2 SOS2 SRC SRC FGF1 FGF1 LY9 LY9 CBLC CBLC ERBB2 ERBB2 ERBB4 ERBB4 CD8B CD8B VEGFD VEGFD CSF1R CSF1R FGF2 FGF2 FGF3 FGF3 FRS3 FRS3 PIK3R1 PIK3R1 FLT4 FLT4 PIK3AP1 PIK3AP1 AREG AREG GFRA3 GFRA3 EREG EREG CSF1 CSF1 KDR KDR CD8A CD8A FGF17 FGF17 CD247 CD247 PIK3CG PIK3CG TGFA TGFA SHC2 SHC2 VEGFC VEGFC NTF3 NTF3 IL34 IL34 EPGN EPGN FGF18 FGF18 KHDRBS3 KHDRBS3 INPPL1 INPPL1 EGFR EGFR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (460 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
MATKTyrosine-protein kinase. (514 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
CD84CD84 molecule. (345 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
CD3DCD3d molecule. (171 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
STAP2Signal transducing adaptor family member 2. (407 aa)
KLBKlotho beta. (1044 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (978 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
FLT3LGUncharacterized protein. (188 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
CD3GCD3g molecule. (182 aa)
ENSPPAP00000006969Uncharacterized protein. (584 aa)
FCER1GUncharacterized protein. (112 aa)
CD72CD72 molecule. (359 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (372 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
ENSPPAP00000009275Uncharacterized protein. (269 aa)
ANGPT4Angiopoietin 4. (503 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PTPN18Protein tyrosine phosphatase non-receptor type 18. (435 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
INSRTyrosine-protein kinase receptor. (1362 aa)
CSKTyrosine-protein kinase. (450 aa)
SHC3SHC adaptor protein 3. (501 aa)
GRAPLGRB2 related adaptor protein like. (100 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
FGRTyrosine-protein kinase. (529 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
NRG1Neuregulin 1. (645 aa)
RALGPS1Ral GEF with PH domain and SH3 binding motif 1. (557 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ANGPTL1Angiopoietin like 1. (491 aa)
GAB2GRB2 associated binding protein 2. (675 aa)
KLKlotho. (1032 aa)
TECTyrosine-protein kinase. (631 aa)
ENSPPAP00000014225Protein kinase domain-containing protein. (433 aa)
LYNTyrosine-protein kinase. (526 aa)
SHC1SHC adaptor protein 1. (584 aa)
CD2CD2 molecule. (351 aa)
FCGR2AFc fragment of IgG receptor IIa. (316 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
ENSPPAP00000015671Protein kinase domain-containing protein. (414 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
LCKTyrosine-protein kinase. (524 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGFR1Fibroblast growth factor receptor. (812 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
ITKTyrosine-protein kinase. (620 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ANGPT2Angiopoietin 2. (495 aa)
CD3ECD3e molecule. (207 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SRMSTyrosine-protein kinase. (491 aa)
PDGFRLPlatelet derived growth factor receptor like. (448 aa)
KHDRBS2KH RNA binding domain containing, signal transduction associated 2. (349 aa)
CD101CD101 molecule. (1017 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
BTCBetacellulin. (178 aa)
FLT1Uncharacterized protein. (736 aa)
NRG4Neuregulin 4. (117 aa)
INSRRTyrosine-protein kinase receptor. (1297 aa)
FGF21Uncharacterized protein. (147 aa)
NRG3Neuregulin 3. (719 aa)
FGFRL1Fibroblast growth factor receptor like 1. (507 aa)
PDGFDPlatelet derived growth factor D. (329 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
SLAMF7SLAM family member 7. (335 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
FGFR3Fibroblast growth factor receptor. (780 aa)
DOK4Docking protein 4. (365 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (812 aa)
SORT1Sortilin. (569 aa)
ENSPPAP00000024034Uncharacterized protein. (541 aa)
NRG2Uncharacterized protein. (705 aa)
STYK1Serine/threonine/tyrosine kinase 1. (422 aa)
CD244CD244 molecule. (367 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1344 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
ENSPPAP00000025160Tyrosine-protein kinase. (483 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FYNTyrosine-protein kinase. (537 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
ANGPT1Angiopoietin 1. (498 aa)
SLAMF6SLAM family member 6. (331 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1027 aa)
ZNRF1Zinc and ring finger 1. (278 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
CD58CD58 molecule. (250 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CD52CD52 molecule. (61 aa)
CD22B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
TXKTyrosine-protein kinase. (527 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LATLinker for activation of T cells. (268 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
ENSPPAP00000029143Uncharacterized protein. (511 aa)
SYKTyrosine-protein kinase. (635 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
HCKTyrosine-protein kinase. (526 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
LOC100984838Uncharacterized protein. (334 aa)
CD53Tetraspanin. (219 aa)
PSPNPersephin. (156 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (296 aa)
CLEC11AC-type lectin domain containing 11A. (323 aa)
BTKTyrosine-protein kinase. (693 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (186 aa)
CD48CD48 molecule. (252 aa)
YES1Tyrosine-protein kinase. (548 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
DOK2Docking protein 2. (412 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (798 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NGFRNerve growth factor receptor. (427 aa)
FCGR1AUncharacterized protein. (368 aa)
IRS4Insulin receptor substrate 4. (1194 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
GRAPUncharacterized protein. (158 aa)
BLNKB cell linker. (417 aa)
GP6Glycoprotein VI platelet. (606 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
SRCTyrosine-protein kinase. (458 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LY9Lymphocyte antigen 9. (655 aa)
CBLCUncharacterized protein. (387 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
CD8BIg-like domain-containing protein. (243 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
AREGEGF-like domain-containing protein. (274 aa)
GFRA3GDNF family receptor alpha 3. (400 aa)
EREGEpiregulin. (169 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CD8ACD8a molecule. (226 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
CD247CD247 molecule. (163 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
TGFATransforming growth factor alpha. (181 aa)
SHC2Uncharacterized protein. (539 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
IL34Interleukin 34. (242 aa)
EPGNUncharacterized protein. (85 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
KHDRBS3KH RNA binding domain containing, signal transduction associated 3. (346 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1253 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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