STRINGSTRING
ZAP70 ZAP70 MATK MATK PIK3R3 PIK3R3 PAG1 PAG1 CD3D CD3D STAP2 STAP2 PECAM1 PECAM1 IRS1 IRS1 VAV3 VAV3 CD3G CD3G ENSPPAP00000006969 ENSPPAP00000006969 FCER1G FCER1G CD72 CD72 GRAP2 GRAP2 PTPN1 PTPN1 PTPN6 PTPN6 ENSPPAP00000009275 ENSPPAP00000009275 FRS2 FRS2 PTK6 PTK6 PTPN18 PTPN18 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA INSR INSR CSK CSK SHC3 SHC3 GRAPL GRAPL FGR FGR CLEC7A CLEC7A RALGPS1 RALGPS1 GAB2 GAB2 TEC TEC LYN LYN SHC1 SHC1 FCGR2A FCGR2A INPP5D INPP5D LCK LCK ITK ITK PIK3CB PIK3CB CD3E CD3E PLCG1 PLCG1 SRMS SRMS KHDRBS2 KHDRBS2 INSRR INSRR PIK3R6 PIK3R6 PTPRC PTPRC ENSPPAP00000024034 ENSPPAP00000024034 LCP2 LCP2 PIK3CD PIK3CD PTPN11 PTPN11 ENSPPAP00000025160 ENSPPAP00000025160 PTPN22 PTPN22 PIK3R5 PIK3R5 VAV1 VAV1 CD22 CD22 TXK TXK LAT LAT VAV2 VAV2 ENSPPAP00000029143 ENSPPAP00000029143 SYK SYK HCK HCK LOC100984838 LOC100984838 BTK BTK YES1 YES1 GAB1 GAB1 FER FER PLCG2 PLCG2 FCGR1A FCGR1A IRS4 IRS4 GRAP GRAP BLNK BLNK GP6 GP6 LOC103785316 LOC103785316 SOS2 SOS2 SRC SRC CBLC CBLC CD8B CD8B FRS3 FRS3 PIK3R1 PIK3R1 PIK3AP1 PIK3AP1 CD8A CD8A CD247 CD247 PIK3CG PIK3CG SHC2 SHC2 KHDRBS3 KHDRBS3 INPPL1 INPPL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZAP70Tyrosine-protein kinase. (619 aa)
MATKTyrosine-protein kinase. (514 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
CD3DCD3d molecule. (171 aa)
STAP2Signal transducing adaptor family member 2. (407 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
VAV3Vav guanine nucleotide exchange factor 3. (917 aa)
CD3GCD3g molecule. (182 aa)
ENSPPAP00000006969Uncharacterized protein. (584 aa)
FCER1GUncharacterized protein. (112 aa)
CD72CD72 molecule. (359 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
ENSPPAP00000009275Uncharacterized protein. (269 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PTPN18Protein tyrosine phosphatase non-receptor type 18. (435 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
INSRTyrosine-protein kinase receptor. (1362 aa)
CSKTyrosine-protein kinase. (450 aa)
SHC3SHC adaptor protein 3. (501 aa)
GRAPLGRB2 related adaptor protein like. (100 aa)
FGRTyrosine-protein kinase. (529 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
RALGPS1Ral GEF with PH domain and SH3 binding motif 1. (557 aa)
GAB2GRB2 associated binding protein 2. (675 aa)
TECTyrosine-protein kinase. (631 aa)
LYNTyrosine-protein kinase. (526 aa)
SHC1SHC adaptor protein 1. (584 aa)
FCGR2AFc fragment of IgG receptor IIa. (316 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
LCKTyrosine-protein kinase. (524 aa)
ITKTyrosine-protein kinase. (620 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CD3ECD3e molecule. (207 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
SRMSTyrosine-protein kinase. (491 aa)
KHDRBS2KH RNA binding domain containing, signal transduction associated 2. (349 aa)
INSRRTyrosine-protein kinase receptor. (1297 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
ENSPPAP00000024034Uncharacterized protein. (541 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
ENSPPAP00000025160Tyrosine-protein kinase. (483 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
VAV1Vav guanine nucleotide exchange factor 1. (828 aa)
CD22B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
TXKTyrosine-protein kinase. (527 aa)
LATLinker for activation of T cells. (268 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
ENSPPAP00000029143Uncharacterized protein. (511 aa)
SYKTyrosine-protein kinase. (635 aa)
HCKTyrosine-protein kinase. (526 aa)
LOC100984838Uncharacterized protein. (334 aa)
BTKTyrosine-protein kinase. (693 aa)
YES1Tyrosine-protein kinase. (548 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (798 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
FCGR1AUncharacterized protein. (368 aa)
IRS4Insulin receptor substrate 4. (1194 aa)
GRAPUncharacterized protein. (158 aa)
BLNKB cell linker. (417 aa)
GP6Glycoprotein VI platelet. (606 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
SRCTyrosine-protein kinase. (458 aa)
CBLCUncharacterized protein. (387 aa)
CD8BIg-like domain-containing protein. (243 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
CD8ACD8a molecule. (226 aa)
CD247CD247 molecule. (163 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
SHC2Uncharacterized protein. (539 aa)
KHDRBS3KH RNA binding domain containing, signal transduction associated 3. (346 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1253 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.