(37 nodes) Mixed, incl. RET signaling, and Insulin receptor complex network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
	IRS1	Insulin receptor substrate 1. (1242 aa)
	ENSPPAP00000006969	Uncharacterized protein. (584 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	ENSPPAP00000009275	Uncharacterized protein. (269 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (521 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	PIK3R2	Uncharacterized protein. (663 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
	INSR	Tyrosine-protein kinase receptor. (1362 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	SHC3	SHC adaptor protein 3. (501 aa)
	FGR	Tyrosine-protein kinase. (529 aa)
	GAB2	GRB2 associated binding protein 2. (675 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	INSRR	Tyrosine-protein kinase receptor. (1297 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
	ENSPPAP00000024034	Uncharacterized protein. (541 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	ENSPPAP00000025160	Tyrosine-protein kinase. (483 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (807 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
	HCK	Tyrosine-protein kinase. (526 aa)
	GAB1	GRB2 associated binding protein 1. (724 aa)
	IRS4	Insulin receptor substrate 4. (1194 aa)
	GRAP	Uncharacterized protein. (158 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
	SRC	Tyrosine-protein kinase. (458 aa)
	CBLC	Uncharacterized protein. (387 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (492 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	SHC2	Uncharacterized protein. (539 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1253 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBLC	ENSPPAP00000025160	ENSPPAP00000037262	ENSPPAP00000025160	Uncharacterized protein.	Tyrosine-protein kinase.	0.869
CBLC	FGR	ENSPPAP00000037262	ENSPPAP00000012268	Uncharacterized protein.	Tyrosine-protein kinase.	0.471
CBLC	GRAP	ENSPPAP00000037262	ENSPPAP00000034514	Uncharacterized protein.	Uncharacterized protein.	0.676
CBLC	GRB2	ENSPPAP00000037262	ENSPPAP00000009849	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.676
CBLC	HCK	ENSPPAP00000037262	ENSPPAP00000029701	Uncharacterized protein.	Tyrosine-protein kinase.	0.454
CBLC	INPPL1	ENSPPAP00000037262	ENSPPAP00000043090	Uncharacterized protein.	Inositol polyphosphate phosphatase like 1.	0.594
CBLC	PIK3CA	ENSPPAP00000037262	ENSPPAP00000010140	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.409
CBLC	PIK3CB	ENSPPAP00000037262	ENSPPAP00000017401	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.409
CBLC	PIK3CD	ENSPPAP00000037262	ENSPPAP00000025044	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.449
CBLC	PIK3CG	ENSPPAP00000037262	ENSPPAP00000040779	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.401
CBLC	PIK3R1	ENSPPAP00000037262	ENSPPAP00000038775	Uncharacterized protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.568
CBLC	PIK3R2	ENSPPAP00000037262	ENSPPAP00000009952	Uncharacterized protein.	Uncharacterized protein.	0.568
CBLC	PIK3R3	ENSPPAP00000037262	ENSPPAP00000002242	Uncharacterized protein.	Phosphoinositide-3-kinase regulatory subunit 3.	0.568
CBLC	SRC	ENSPPAP00000037262	ENSPPAP00000035810	Uncharacterized protein.	Tyrosine-protein kinase.	0.954
CSK	ENSPPAP00000006969	ENSPPAP00000010344	ENSPPAP00000006969	Tyrosine-protein kinase.	Uncharacterized protein.	0.590
CSK	ENSPPAP00000009275	ENSPPAP00000010344	ENSPPAP00000009275	Tyrosine-protein kinase.	Uncharacterized protein.	0.590
CSK	ENSPPAP00000024034	ENSPPAP00000010344	ENSPPAP00000024034	Tyrosine-protein kinase.	Uncharacterized protein.	0.590
CSK	ENSPPAP00000025160	ENSPPAP00000010344	ENSPPAP00000025160	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.782
CSK	FGR	ENSPPAP00000010344	ENSPPAP00000012268	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.583
CSK	GAB1	ENSPPAP00000010344	ENSPPAP00000033073	Tyrosine-protein kinase.	GRB2 associated binding protein 1.	0.541