(18 nodes) Mixed, incl. TNFs bind their physiological receptors, and Cytotoxic T-lymphocyte protein 4/CD28 network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNFSF18	TNF superfamily member 18. (199 aa)
	CD276	Ig-like domain-containing protein. (280 aa)
	TNFRSF4	TNF receptor superfamily member 4. (254 aa)
	CD70	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (193 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (273 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	CD86	CD86 molecule. (329 aa)
	CD28	CD28 molecule. (220 aa)
	CD27	CD27 molecule. (260 aa)
	ICOSLG	Uncharacterized protein. (463 aa)
	ICOS	Inducible T cell costimulator. (199 aa)
	TNFRSF18	TNFR-Cys domain-containing protein. (347 aa)
	CD80	CD80 molecule. (288 aa)
	CD40	CD40 molecule. (277 aa)
	TNFRSF9	TNF receptor superfamily member 9. (226 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	TNFSF9	TNF superfamily member 9; Belongs to the tumor necrosis factor family. (253 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD27	CD276	ENSPPAP00000027010	ENSPPAP00000009245	CD27 molecule.	Ig-like domain-containing protein.	0.614
CD27	CD28	ENSPPAP00000027010	ENSPPAP00000023667	CD27 molecule.	CD28 molecule.	0.783
CD27	CD40	ENSPPAP00000027010	ENSPPAP00000033584	CD27 molecule.	CD40 molecule.	0.445
CD27	CD40LG	ENSPPAP00000027010	ENSPPAP00000039865	CD27 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.787
CD27	CD70	ENSPPAP00000027010	ENSPPAP00000012314	CD27 molecule.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.999
CD27	CD80	ENSPPAP00000027010	ENSPPAP00000033006	CD27 molecule.	CD80 molecule.	0.907
CD27	CD86	ENSPPAP00000027010	ENSPPAP00000021183	CD27 molecule.	CD86 molecule.	0.909
CD27	CTLA4	ENSPPAP00000027010	ENSPPAP00000037872	CD27 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.637
CD27	ICOS	ENSPPAP00000027010	ENSPPAP00000028122	CD27 molecule.	Inducible T cell costimulator.	0.690
CD27	ICOSLG	ENSPPAP00000027010	ENSPPAP00000027175	CD27 molecule.	Uncharacterized protein.	0.663
CD27	PDCD1LG2	ENSPPAP00000027010	ENSPPAP00000015108	CD27 molecule.	Programmed cell death 1 ligand 2.	0.459
CD27	TNFRSF18	ENSPPAP00000027010	ENSPPAP00000031183	CD27 molecule.	TNFR-Cys domain-containing protein.	0.684
CD27	TNFRSF4	ENSPPAP00000027010	ENSPPAP00000010893	CD27 molecule.	TNF receptor superfamily member 4.	0.713
CD27	TNFRSF9	ENSPPAP00000027010	ENSPPAP00000036251	CD27 molecule.	TNF receptor superfamily member 9.	0.693
CD27	TNFSF18	ENSPPAP00000027010	ENSPPAP00000000912	CD27 molecule.	TNF superfamily member 18.	0.569
CD27	TNFSF4	ENSPPAP00000027010	ENSPPAP00000017916	CD27 molecule.	TNF superfamily member 4; Belongs to the tumor necrosis factor family.	0.813
CD27	TNFSF9	ENSPPAP00000027010	ENSPPAP00000041654	CD27 molecule.	TNF superfamily member 9; Belongs to the tumor necrosis factor family.	0.800
CD276	CD27	ENSPPAP00000009245	ENSPPAP00000027010	Ig-like domain-containing protein.	CD27 molecule.	0.614
CD276	CD28	ENSPPAP00000009245	ENSPPAP00000023667	Ig-like domain-containing protein.	CD28 molecule.	0.938
CD276	CD40LG	ENSPPAP00000009245	ENSPPAP00000039865	Ig-like domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.722