(10 nodes) Mixed, incl. Cytotoxic T-lymphocyte protein 4/CD28, and CD40 signaling pathway network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD276	Ig-like domain-containing protein. (280 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (273 aa)
	CD86	CD86 molecule. (329 aa)
	CD28	CD28 molecule. (220 aa)
	ICOSLG	Uncharacterized protein. (463 aa)
	ICOS	Inducible T cell costimulator. (199 aa)
	CD80	CD80 molecule. (288 aa)
	CD40	CD40 molecule. (277 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD276	CD28	ENSPPAP00000009245	ENSPPAP00000023667	Ig-like domain-containing protein.	CD28 molecule.	0.938
CD276	CD40LG	ENSPPAP00000009245	ENSPPAP00000039865	Ig-like domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.722
CD276	CD80	ENSPPAP00000009245	ENSPPAP00000033006	Ig-like domain-containing protein.	CD80 molecule.	0.828
CD276	CD86	ENSPPAP00000009245	ENSPPAP00000021183	Ig-like domain-containing protein.	CD86 molecule.	0.820
CD276	CTLA4	ENSPPAP00000009245	ENSPPAP00000037872	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte associated protein 4.	0.852
CD276	ICOS	ENSPPAP00000009245	ENSPPAP00000028122	Ig-like domain-containing protein.	Inducible T cell costimulator.	0.689
CD276	ICOSLG	ENSPPAP00000009245	ENSPPAP00000027175	Ig-like domain-containing protein.	Uncharacterized protein.	0.566
CD276	PDCD1LG2	ENSPPAP00000009245	ENSPPAP00000015108	Ig-like domain-containing protein.	Programmed cell death 1 ligand 2.	0.400
CD28	CD276	ENSPPAP00000023667	ENSPPAP00000009245	CD28 molecule.	Ig-like domain-containing protein.	0.938
CD28	CD40LG	ENSPPAP00000023667	ENSPPAP00000039865	CD28 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.927
CD28	CD80	ENSPPAP00000023667	ENSPPAP00000033006	CD28 molecule.	CD80 molecule.	0.999
CD28	CD86	ENSPPAP00000023667	ENSPPAP00000021183	CD28 molecule.	CD86 molecule.	0.999
CD28	CTLA4	ENSPPAP00000023667	ENSPPAP00000037872	CD28 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.854
CD28	ICOS	ENSPPAP00000023667	ENSPPAP00000028122	CD28 molecule.	Inducible T cell costimulator.	0.825
CD28	ICOSLG	ENSPPAP00000023667	ENSPPAP00000027175	CD28 molecule.	Uncharacterized protein.	0.967
CD28	PDCD1LG2	ENSPPAP00000023667	ENSPPAP00000015108	CD28 molecule.	Programmed cell death 1 ligand 2.	0.807
CD40	CD40LG	ENSPPAP00000033584	ENSPPAP00000039865	CD40 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.999
CD40	CD80	ENSPPAP00000033584	ENSPPAP00000033006	CD40 molecule.	CD80 molecule.	0.945
CD40	CD86	ENSPPAP00000033584	ENSPPAP00000021183	CD40 molecule.	CD86 molecule.	0.950
CD40	CTLA4	ENSPPAP00000033584	ENSPPAP00000037872	CD40 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.687