(30 nodes) Regulation of IFNA/IFNB signaling, and Interleukin-21 signaling network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	IFNA14	Interferon alpha 14. (189 aa)
	IFNA6	Interferon alpha 6. (189 aa)
	LOC100972005	Uncharacterized protein. (198 aa)
	IFNA5	Interferon alpha 5. (189 aa)
	IFNA10	Interferon alpha 10. (189 aa)
	IFNA8	Interferon alpha 8. (189 aa)
	IRF9	Interferon regulatory factor 9. (392 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (558 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	JAK2	Tyrosine-protein kinase. (1143 aa)
	IFNW1	Interferon omega 1. (200 aa)
	IFNGR2	Interferon gamma receptor 2. (347 aa)
	SOCS7	Suppressor of cytokine signaling 7. (518 aa)
	ENSPPAP00000016834	Uncharacterized protein. (195 aa)
	IFNGR1	Interferon gamma receptor 1. (489 aa)
	IFNA7	Interferon alpha 7. (189 aa)
	EPOR	Erythropoietin receptor; Receptor for erythropoietin. (508 aa)
	IFNAR2	Uncharacterized protein. (519 aa)
	STAT4	Signal transducer and activator of transcription. (742 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (424 aa)
	TYK2	Tyrosine-protein kinase. (1190 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	STAT5B	Signal transducer and activator of transcription. (789 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	JAK3	Tyrosine-protein kinase. (1090 aa)
	STAT2	Signal transducer and activator of transcription. (853 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPPAP00000016834	EPOR	ENSPPAP00000016834	ENSPPAP00000021509	Uncharacterized protein.	Erythropoietin receptor; Receptor for erythropoietin.	0.671
ENSPPAP00000016834	IFNA10	ENSPPAP00000016834	ENSPPAP00000002120	Uncharacterized protein.	Interferon alpha 10.	0.546
ENSPPAP00000016834	IFNA14	ENSPPAP00000016834	ENSPPAP00000001536	Uncharacterized protein.	Interferon alpha 14.	0.764
ENSPPAP00000016834	IFNA5	ENSPPAP00000016834	ENSPPAP00000002053	Uncharacterized protein.	Interferon alpha 5.	0.580
ENSPPAP00000016834	IFNA6	ENSPPAP00000016834	ENSPPAP00000001777	Uncharacterized protein.	Interferon alpha 6.	0.736
ENSPPAP00000016834	IFNA8	ENSPPAP00000016834	ENSPPAP00000002574	Uncharacterized protein.	Interferon alpha 8.	0.592
ENSPPAP00000016834	IFNAR1	ENSPPAP00000016834	ENSPPAP00000003428	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.978
ENSPPAP00000016834	IFNAR2	ENSPPAP00000016834	ENSPPAP00000023959	Uncharacterized protein.	Uncharacterized protein.	0.940
ENSPPAP00000016834	IFNG	ENSPPAP00000016834	ENSPPAP00000038608	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.713
ENSPPAP00000016834	IFNGR1	ENSPPAP00000016834	ENSPPAP00000018629	Uncharacterized protein.	Interferon gamma receptor 1.	0.879
ENSPPAP00000016834	IFNGR2	ENSPPAP00000016834	ENSPPAP00000006711	Uncharacterized protein.	Interferon gamma receptor 2.	0.840
ENSPPAP00000016834	IRF9	ENSPPAP00000016834	ENSPPAP00000002942	Uncharacterized protein.	Interferon regulatory factor 9.	0.708
ENSPPAP00000016834	JAK1	ENSPPAP00000016834	ENSPPAP00000003673	Uncharacterized protein.	Tyrosine-protein kinase.	0.910
ENSPPAP00000016834	JAK2	ENSPPAP00000016834	ENSPPAP00000004553	Uncharacterized protein.	Tyrosine-protein kinase.	0.535
ENSPPAP00000016834	JAK3	ENSPPAP00000016834	ENSPPAP00000036401	Uncharacterized protein.	Tyrosine-protein kinase.	0.775
ENSPPAP00000016834	SOCS3	ENSPPAP00000016834	ENSPPAP00000003781	Uncharacterized protein.	Suppressor of cytokine signaling 3.	0.558
ENSPPAP00000016834	STAT1	ENSPPAP00000016834	ENSPPAP00000033854	Uncharacterized protein.	Signal transducer and activator of transcription.	0.732
ENSPPAP00000016834	STAT2	ENSPPAP00000016834	ENSPPAP00000038370	Uncharacterized protein.	Signal transducer and activator of transcription.	0.731
ENSPPAP00000016834	STAT3	ENSPPAP00000016834	ENSPPAP00000035951	Uncharacterized protein.	Signal transducer and activator of transcription.	0.540
ENSPPAP00000016834	STAT4	ENSPPAP00000016834	ENSPPAP00000030521	Uncharacterized protein.	Signal transducer and activator of transcription.	0.596